CUTM 1649 Modern and Applied Analytical Forensic Chemistry
Teacher
Dr. Reena C. Jhamtani
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Core Courses
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Course Name : Modern and Applied Analytical Forensic Chemistry
Code(Credit) : CUTM1649(4-2-0)
Course Objectives
- This course aims to build in students both theoretical knowledge and practical application of forensic chemistry such as investigation of arson cases, analysis of samples.
- Understanding of nuclear forensics, detection and measurement of radioactive substances.
- Understanding of drugs chemistry, NDPS laws and analytical method.
- Understanding and identification of fire crime scene and explosion crime scene.
- Analysis of petroleum products
- food adulteration and their detection.
Learning Outcomes
After completing this course students will have theoretical and practical knowledge of Forensic Chemistry.
- Acquainted with proper knowledge chemistry of drugs and different laws related to drugs.
- Understanding the process of analysis involved to identify the drugs.
- Ability to detect the different drug component. Identify and detect the cause of fire and explosion and analyse the residue materials.
- Skill to detect the food adulteration in food and identify the adulterated material in food.
Course Syllabus
UNIT-I
Forensic nuclear chemistry
Introduction to nuclear forensics, nuclear threats, Nuclear explosive devices, Radioactivity, Radioactive decay rates and Half lives, Methods of detection and measurement of radio actives (G.M and Scintillation Counter). Applications of Radioisotopes.
Activation analysis:
Neutron activation analysis, principle, technique, applications and steps involved in neutron activation analysis.
Isotope dilution analysis:
Principle, types of isotope dilution analysis, typical applications of isotope dilution analysis.
UNIT-II
Forensic Drug Chemistry
Introduction to Drugs, Controlled Substance Act, Forensic examination of drugs/Narcotics (Cannabis), Phenethylamines (Amphetamine, Methamphetamine), Hydroxyl derivative (Ephedrine) Ketone Derivative (Cathinone), Methoxy Derivative (Mescaline) Tertiary Amines (Cocaine and Opiates) Tryptamines(Psilocin and Psilocybin) Anabolic Steroids, Miscellaneous Controlled Substances (Barbiturates, Benzodiazepines, GHB, Ketamine and LSD)Sample Preparation, Extraction Techniques- Chemical-color test, Microcrystal techniques and other instrumental techniques involved in analysis.
UNIT-III
Petroleum Chemistry
Paraffins, , Iso-olefins, Olefin Hydrocarbons, Naphthenes,Cycloparaffins or Aromatic Hydrocarbons, Sulphur Compounds, Nitrogen Compounds, Oxygen Compounds, Organo-Metallic Hydrocarbons; H/C Ratio of Hydrocarbons;Physical Properties of Petroleum Products : Density, Viscosity, Surface Tension, Color, Fluorescence, Cloud Point, Pour Point, Aniline Point, smoke point, boiling point, Optical Properties, Flash Point, Refractive Index and Calorific Value, Determination of Cetane and Octane number, Analytical Techniques: Quantitative and Qualitative Steps in Analysis of Petroleum
Fire Chemistry
Scientific Investigation of Fire, NEPA 921 and NEPA 1033, The chemistry and physics of combustion, Dynamics of Fire, Development of fire patterns, Separation and analytical techniques of ignitable liquid residues, Field tests, Interpretation of Data Obtained from Fire Debris, Quality Assurance in Fire debris Analysis, Report Writing and Court Testimony.
UNIT-IV
Explosives Chemistry
Introduction and assessment of explosives , Oxygen balance, Explosive Power Index, Heat and Temperature of Explosion, Pressure of explosion, Mechanism of Ignition and hot spot formation. Thermal decomposition , physical and chemical aspects of combustion, Deflagration and Detonation, Kinetics of Explosive Reactions, Analysis of low and high explosives by different instrumental techniques, Quality control, Proficiency Testing, Interpretation and Significance of Results
Chemical Warfare Agents
Classification, physical and biochemical properties, toxic effects detection by Biosensors and various instrumental Techniques
UNIT-V
Food Chemistry
Analysis of Lipids and fats: Physical examination of lipids, Chemical examination of lipids (Acid value, Saponification value, Ester value, Acetyl value, Iodine value), Test for hydrogenated oils and fats, Detection and Determination of rancidity, Analysis of butter and butter fats, Analysis of adulterated and non-adulterated oils
Analysis of dairy products: Milk and its products.
Practicals
1. Microcrystalline tests for drugs
2. Separation of alkaloids, glycosides, tryptamines by TLC
3. Separation of Psychotropic substance by TLC
4. Separation of Cannabis/Opium by TLC
5. Separation of lipids by TLC
6. Analysis of high explosives by color test and TLC.
7. Extraction of caffeine from tea leaves, characterization by IR.
8. Estimation of protein in food samples.
9. Analysis of calcium and magnesium in milk.
10. Analysis of fire residues by GC
11. Analysis of adulterated and non-adulterated oil by chemical/Color Test and TLC method
12. Analysis of dye in petrol and kerosene by UV spectrophotometry and TLC
13. Estimation of nitrite/nitrate in water samples
14. Separation of amino acids by thin layer chromatography
15. Analysis of NDPS drugs and explosives by instrumental techniques.
Reference Books:
1. Klaassen, C. D.,:Casarett and Doull’s Toxicology: The Basic Science of Poisons, 5th ed, McGraw-Hill, 1995.
2. Moffat, A.C.: Osselton, D. M. Widdop, B.: Clarke’s Analysis of Drugs and Poisons in Pharmaceuticals, body fluids and postmortem material, 3rd ed., Pharmaceutical Press2004.
3. Bogusz, M. J., Hand Book of Analytical Separations, Vol. 2: Forensic Science, 1st ed., Elsevier Science, 2000.
4. Siegel, J.A., Saukko, P. J., Knupfer, G.,: Encyclopedia of Forensic Sciences (Vol3), Academic Press, 2000.
5. Rang, P.H., Dale, M.M., Ritter, M.J.: Pharmacology, 4th ed., Harcourt/Churchill Livingstone, 2000.
6. Paranjape, H.M., Bothara, G.K., Jain, M.M.: Fundamentals of Pharmacology, 1st ed., Nirali Prakashan, 1990.
7. Budhiraja, R.D.: Elementary Pharmacology and Toxicology, Popular Prakashan, 2nd ed., 1999.
8. Wiseman, H and Henry J.: Management Of Poisoning, A Handbook for Healthcare workers, 1st ed., A.I.T.B.S, 2002
9. Hardman, J. G. and Limbird, L. E.,: Goodman and Gilman’s The Pharmacological basis of Therapeutics, 9th edn., McGraw-Hill, 1996
10. Laaboratory procedure Manual, Forensic Toxicology: DFS, 2005
11. Sunshine, I ; Methods for Analytical Toxicology, CRC Presss USA (1975)
12. Cravey, R.H; Baselt, R.C.: Introduction to Forensic Toxicology , Biochemical Publications, Davis, C.A. (1981)
13. Stolmen, A.; Progress in Chemical Toxicology: Academic Press, New York (1963)
14. Modi, Jaisingh, P.; Textbook of Medical Jurisprudence& Toxicology, M.M. Tripathi Publication (2001)
15. Eckert; An Introduction to Forensic Science, CRC Press
16. Pillay, V. V.; Handbook of Forensic Medicine and Toxicology, Paras Pub., 2001
17. Curry, A. S: Poison Detection in Human Organ
18. James, S. H. and Nordby, J. J.: Forensic Science: An Introduction to Scientific and Investigative Techniques, 2003.
19. Saferstein, R: Criminalistics - An Introduction to Forensic Science, Prentice Hall, 1995.
20. Sarkar, S: Fuels and Combustion, Orient Longman, 1990
21. Verma, R. M: Analytical Chemistry – Theory and Practice, CBS Pub., 1994
22. Svehla, G. Ed.: Vogel’s Qualitative Inorganic Analysis, Longman, 1998.
23. Bassett: Vogel’s Text Book of Quantitative Inorganic Analysis, Longman, 1978
24. Vogel, A. I: Text Book of Practical Organic Chemistry including Qualitative Organic Analysis, ELBS, 1971.
25. Skoog, D. A., West, D. M. and Holler, F. J: Analytical Chemistry: An Introduction, Saunders College, 1994.
26. Siegel, J. A, Saukko, P. J. and Knupfer, G. C: Encyclopedia of Forensic Sciences, Academic Press, 2000.
27. Townsends, A. (Ed): Encyclopedia of Analytical Science, Academic Press, 2005.
28. Beveridge, A: Forensic Investigation of Explosives, Taylor & Francis, 2000.
29. Yallop, H. J: Explosion Investigation, Forensic Science Society & Scottish Academic Press, 1980.
30. Narayanan, T. V: Modern Techniques of Bomb Detection and Disposal, R. A. Security System, 1995.
31. Yinon, J. and Zitrin, S: The Analysis of Explosives, Oxford: Pergamon, 1981
32. An Introduction to Physics and chemistry of Petroleum
33. Kinghorn: Introduction to Petrochemicals Sukumar Maiti
34. D.W.Waples : Geochemistry in Petroleum Exploration
35. A.L.Waddams : Petroleum Geochemistry and Geology Chemicals from Petroleum
36. Day& Underwood :Analytical Chemistry
37. H. J. Arnikar Essentials of Nuclear Chemistry, 4th Edition Wiley Eastern (1987).
38. H. J. M. Bowen. Buttler and Tanner Chemical Applications of Radioisotopes, (1969).
39. G Friedlander, T. W. Kennedy, E. S. Macias and J. M. Miller, Introduction of Nuclear and Radiochemistry, 3rd Edition, John Wiley (1981).
40. P.D.Vowels and D.W: Experiments in Environmental chemistry.
Session Plan- Theory
Session 1
Introduction to nuclear forensics
Session 3
Radioactivity, Radioactive decay rates and Half lives
Session 4
Methods of detection and measurement of radio actives (G.M and Scintillation Counter)
Detection and Measurement of Radioactivity_ Scintillation Counter
Detection and Measurement of Radioactivity_ Geiger Muller Counter ans Scintillation Counter
Session 6
Activation analysis:
Neutron activation analysis, principle, technique, applications and steps involved in neutron activation analysis.
Session 7
Isotope dilution analysis:
Principle, types of isotope dilution analysis, typical applications of isotope dilution analysis.
Session 8
Introduction to Drugs, Controlled Substance Act
https://dfs.virginia.gov/wp-content/uploads/221-D100-Controlled-Substances-Procedures-Manual.pdf
Session 9
Forensic examination of drugs/Narcotics (Cannabis)
Identification_and_Analysis_of_Cannabis_and_Cannabis_products
Session 10
Forensic examination of drugs- Phenethylamines (Amphetamine, Methamphetamine)
https://www.emcdda.europa.eu/publications/drug-profiles/amphetamine_en
Session 11
Forensic examination of drugs/ Narcotics- Hydroxyl derivative (Ephedrine) Ketone Derivative (Cathinone)
Session 12
Forensic examination of drugs/ Narcotics- Methoxy Derivative (Mescaline) Tertiary Amines (Cocaine and Opiates)
chapter 5, 7 and 12
Session 13
Forensic examination of drugs/ Narcotics- Tryptamines (Psilocin and Psilocybin) Anabolic Steroids
chapter 13 of narcotic manual
Session 14
Forensic examination of drugs/ Narcotics- Miscellaneous Controlled Substances (Barbiturates, Benzodiazepines, GHB, Ketamine and LSD)
chapter 10, 11 and 14 of narcotic manual
Session 15
Sample Preparation, Extraction Techniques- Chemical-color test
Session 15
Micro crystal techniques and other instrumental techniques involved in analysis
https://www.wcupa.edu/sciences-mathematics/chemistry/forensicResearch/
Session 16
Petroleum Chemistry: Paraffins, , Iso-olefins, Olefin Hydrocarbons, Naphthenes
Session 17
Cycloparaffins or Aromatic Hydrocarbons, Sulphur Compounds, Nitrogen Compounds
Session 18
Oxygen Compounds, Organo-Metallic Hydrocarbons; H/C Ratio of Hydrocarbons;
Session 19
Physical Properties of Petroleum Products : Density, Viscosity, Surface Tension, Color, Fluorescence, Cloud Point, Pour Point, Aniline Point, smoke point
Session 20
Physical Properties of Petroleum Products : boiling point, Optical Properties, Flash Point, Refractive Index and Calorific Value, Determination of Cetane and Octane number
Session 21
Analytical Techniques: Quantitative and Qualitative Steps in Analysis of Petroleum
Session 22
Fire Chemistry
Scientific Investigation of Fire, NEPA 921 and NEPA 1033
Session 24
Dynamics of Fire, Development of fire patterns
https://www.powershow.com/view1/53caa-ZDc1Z/FIRE_PATTERNS_powerpoint_ppt_presentation
Session 25
Separation and analytical techniques of ignitable liquid residues, Field tests
Session 27
Quality Assurance in Fire debris Analysis, Report Writing and Court Testimony
Session 28
Explosives Chemistry
Introduction and assessment of explosives , Oxygen balance
Session 29
Explosive Power Index, Heat and Temperature of Explosion, Pressure of explosion
Session 31
Thermal decomposition , physical and chemical aspects of combustion, Deflagration and Detonation
Session 33
Analysis of low and high explosives by different instrumental techniques
Session 34
Quality control, Proficiency Testing, Interpretation and Significance of Results
Session 35
Chemical Warfare Agents
Classification, physical and biochemical properties
Session 36
Chemical Warfare Agents
toxic effects detection by Biosensors and various instrumental Techniques
Session 37
Analysis of Lipids and fats: Physical examination of lipids
https://people.umass.edu/~mcclemen/581Lipids.html
https://duhslibrary.ac.in/Content/567_19_1491301103P05M03Lipids-Propertiesfignc.pdf
Session 38
Analysis of Lipids and fats: Chemical examination of lipids (Acid value, Saponification value, Ester value, Acetyl value, Iodine value)
Session 39
Test for hydrogenated oils and fats
Detection and Determination of rancidity
https://www.youtube.com/watch?v=FhuWvWX9-yQ
Analysis of butter and butter fats
Analysis of adulterated and non-adulterated oils
Session 40
Analysis of dairy products: Milk and its products.
Session Plan- Practical
Practical session 1
Microcrystalline tests for drugs
Practical session 2
Separation of alkaloids, glycosides, tryptamines by TLC
Practical session 3
Separation of Psychotropic substance by TLC
Practical session 4
Separation of Cannabis/Opium by TLC
Practical Session 5
Separation of lipids by TLC
Practical session 6
Analysis of high explosives by color test and TLC.
Practical session 7
Extraction of caffeine from tea leaves, characterization by IR
Practical session 8
Estimation of protein in food samples
Practical session 9
Analysis of calcium and magnesium in milk.
Practical session 10
Analysis of fire residues by GC
Practical session 11
Analysis of adulterated and non-adulterated oil by chemical/Color Test and TLC method
Practical session 12
Analysis of dye in petrol and kerosene by UV spectrophotometry and TLC
Practical session 13
Estimation of nitrite/nitrate in water samples
Practical session 14
Separation of amino acids by thin layer chromatography
Practical session 15
Analysis of NDPS drugs and explosives by instrumental techniques
Our Main Teachers
Associate Professor at the School of Forensic Sciences, Centurion University of Technology and Management, Orrisa, Bhubaneshwar.