PHARMACEUTICAL CHEMISTRY

Domain Track Title:

PHARMACEUTICAL CHEMISTRY

Domain Track Code (Credit):

PCCU2370 (4-0-0)

Courses Division( List all divisions):

1. Physical Chemistry of Pharmaceuticals

2. Essentials of Pharmaceutical Chemistry

3. Analytical Techniques for Pharmaceutical Drugs

Domain Track Objectives:

To know the classification of drug, physical properties and its mechanism of action on human physiological system

Domain Track Learning Outcomes:

• To know various types of drugs and its application towards the diseases.

• To understand physical and chemical behavior of drugs by using instrumental methods.

• Students will understand different physico-chemical properties pertaining to biological actions.

Domain Syllabus:

Module-I

Basic Principles of Medicinal Chemistry: Physico-chemical aspects (Optical, geometric and bioisosterism) of drug molecules and biological action. Basic concepts of: Drug metabolism, Prodrugs, Receptors and drug receptor interaction.

Module-II

Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, factors influencing solubility of drugs, quantitative approach to the solubility, diffusion principles in biological systems.

Module-III    

Classification and uses of the following classes of drugs, with some suitable examples.

Drugs acting on Gastrointestinal tract.

Drugs acting on Central nervous System, Hormones and related drugs, Drugs affecting cardiovascular system, Drugs acting on Blood and Blood Formation

Modules-IV

Classification and uses of the following classes of drugs, with some suitable examples.

Chemotherapeutic agents, Antibiotics

Modules-V

UV-Visible spectroscopy: Beer and Lambert’s law, Derivation and deviations. Instrumentation. Applications. Spectrophotometric titrations, Single component and multi component analysis.

IR spectroscopy: Introduction, fundamental modes of vibrations in poly atomic molecules, sample handling, factors affecting vibrations and Instrumentation.

Reference

1. Wilson and Giswold’s Organic medicinal and Pharmaceutical Chemistry.

2. Essentials of medical Pharmacology, KD Tripathi, Seventh Edition, 2013, Jaypee Brothers Medical Publishers (P) Ltd.

3. Medicinal Chemistry by Ashutosh Kar, New Age International Publishers, 5^th revised and expanded Edn, 2010.

4. Foye’s Principles of Medicinal Chemistry, Lippincott Williams & Wilkins, 7^th Edition, 2012.

5. Instrumental Methods of Chemical Analysis by B.K Sharma

6. Organic spectroscopy by Y.R Sharma

7. Text book of Pharmaceutical Analysis by Kenneth A. Connors

8. Physical Pharmacy by Alfred Martin

Session Plan for the Entire Domain:

Session 1

Basic Principles of Medicinal Chemistry

PDF: Lecture note on Basic Principles of Medicinal Chemistry

http://Lecture note on Basic Principles of Medicinal Chemistry

Session 2

Physicochemical aspects of drug

https://www.slideshare.net/jaymaa/physicochemical-properties-of-drug

Session 3

Stereochemistry of drugs

https://www.slideshare.net/seetaram443/stereochemistry-53703561

Session 4

Pharmacodynamics of drug-I

PDF: Lecture note on Pharmacodynamics of drug

http://Lecture note on Pharmacodynamics of drug

Session 5

Pharmacodynamics of drug-II

PDF: Lecture note on Pharmacodynamics of drug

http://Lecture note on Pharmacodynamics of drug

Session 6

Solubility of drugs

PDF: Lecture note on solubility of drugs

http://Lecture note on solubility of drugs

Session 7

Quantitative approach to solubility

PDF: Lecture note on quantitative approach to solubility

http://Lecture note on quantitative approach to solubility

Session 8

Drugs acting on Gastrointestinal tract

PDF: Lecture note on Drugs acting on GIT

http://Lecture note on Drugs acting on GIT

Session 9

Drugs acting on Central nervous system

PDF: Lecture note on Drugs acting on CNS

http://Lecture note on Drugs acting on CNS

Session 10

Hormonal drugs

https://www.slideshare.net/E_neutron/hormonal-drugs

Session 11

Drugs acting on Cardiovascular System

PDF: Lecture note on Drugs acting on CVS

http://Lecture note on Drugs acting on CVS

Session 12

Drugs acting on Blood and Blood Formation

PDF: Lecture note on blood and blood formation

http://Lecture note on blood and blood formation

Session 13

Chemotherapeutic agents-I

PDF: Lecture note on chemotherapeutic agent

http://Lecture note on chemotherapeutic agent

Session 14

Chemotherapeutic agents-II

PDF: Lecture note on chemotherapeutic agent

Session 15

Antibiotics-I

PDF: Lecture note on antibiotics

Session 16

Antibiotics-II

PDF: Lecture note on antibiotics

Session 17

Antibiotics-III

PDF: Lecture note on antibiotics

Session 18

Antibiotics-IV

PDF: Lecture note on antibiotics

Session 19

Antibiotics-V

PDF: Lecture note on antibiotics

Session 20

Electronic transitions, chromophores, auxochromes, spectral shifts

PDF: Lecture note on electronic transitions, chromophores, auxochromes, spectral shifts

Session 21

Solvent effect on absorption spectra, Beer and Lambert’s law, Derivation and deviations

PDF: Lecture note on Solvent effect on absorption spectra, Beer and Lambert’s law, Derivation and deviations

Session 22

Instrumentation - Sources of radiation, wavelength selectors, sample cells, detectors- Photo tube, Photomultiplier tube, Photovoltaic cell, Silicon Photodiode. photodetectors

PDF: Lecture note on instrumentation of UV

Session 23

Applications - Spectrophotometric titrations, Single-component, and multi-component analysis

PDF: Lecture note on applications of UV

Session 24

Introduction, Fundamental modes of vibrations in polyatomic molecules

https://www.slideshare.net/sherishahine/infrared-spectroscopy-32876736

Session 25

Instrumentation - Sources of radiation, wavelength selectors,

PDF: Lecture note on instrumentation of IR

Session 26

Detectors - Golay cell, Bolometer, Thermocouple, Thermister, Pyroelectric detector

PDF: Lecture note on detectors

Session 27

Applications of IR spectroscopy

PDF: Lecture note on applications of IR