Course Objectives

• Work to promote good health by teaching the public and other health professionals about diet and nutrition.
• To demonstrate clinical disorders, the biochemical consequences of particular disease process and the response to therapy.
• To describe the various intracellular controls that govern the rate at which the metabolic pathway functions.
• To explain the ways in which hormones work in human body and alter cellular activity by binding to intracellular receptors.

Learning Outcomes

•  Students will be able to demonstrate an understanding of fundamental biochemical principles, such as the structure/function of metabolic pathways, and the regulation of biological/biochemical processes.
• Able to apply and effectively communicate scientific reasoning and data analysis in both written and oral forums.
• Demonstrate a thorough knowledge of the intersection between the disciplines of Biology and Chemistry.
• Appreciate the way in which practitioners in the disciplines of Biology and Chemistry intersect and bring their expertise to bear in solving complex problems involving living systems.

Course Syllabus

Module I

Chemical aspects of Food, Nutrition and Vitamins: Energy yielding nutrients and Calorific value of carbohydrates, fats and proteins. Basal metabolic rate (BMR) and Body Mass Index (BMI). The Food Pyramid. History, Chemistry, Absorption, transport, and storage of Vitamins, Metabolic functions and Biochemical manifestations of Water soluble Vitamins-B-Complex Vitamins : Vitamin –B1,Vitamin – B2,Vitamin-B3,Vitamin –B6, Biotin, Panthothenic acid, Folic acid, Vitamin-B12.Coenzymes of B-Complex Vitamins. Fat soluble Vitamins: Vitamin -A, Vitamin - D, Vitamin-E, Vitamin- K.

Practice: Calculation of BMR and BMI.

Module II

Cellular Respiration: Aerobic and anaerobic respiration; Energy yield and regulation. Oxidation of fatty acid, Transamination and Deamination reaction, Urea formation and transport, Ketogenesis.

Practice: Solutions: Definition, use, classification, preparation and storage. Stock and working solutions. Molar and Normal solutions of compounds and acids. (NaCl, NaOH)

Module III

Biochemical aspects of Hormone:Hormone receptors and intracellular messengers, Adenylate cyclase, protein kinase and phosphodiesterase. Role of Insulin, glucagon’s, epinephrine and their mechanism of action.

Practice:Diabetes and other disorder identification.

Suggested Readings:

Lehninger Principles of Biochemistry.

Ebook link- https://www.pdfdrive.com/lehninger-principles-of-biochemistry-5th-edition-e164892141.html

Fundamentals of Biochemistry:Life at the Molecular Level.

Ebook Link- https://www.pdfdrive.com/fundamentals-of-biochemistry-life-at-the-molecular-level-e186753533.html

Simulation Link For Lab- https://www.youtube.com/user/amritavlab

Session Plan

Session 1

Lecture Topic- Introduction to Biological chemistry.

Lecture Video- https://youtu.be/tpBAmzQ_pUE

Lecture Notes- https://www.slideshare.net/ammedicinemedicine/chapter1-33709114

Session 2

Lecture Topic- Energy yielding nutrients.

Lecture Video- https://www.youtube.com/watch?v=jqrVl4V5ttQ

Lecture Notes- https://www.slideshare.net/RonaldoPaulino2/chapter-1-nutrition

Session 3

Lecture Topic- Calorific value of carbohydrates, fat and protein.

Lecture Video- https://www.youtube.com/watch?v=RSDwMVQ7G9w

LecturePresentation- https://www.slideshare.net/abhishek198thakur/energy-values-of-foods

Session 4

Lecture Topic- Basal metabolic rate (BMR) and Body Mass Index (BMI).

Lecture Video- https://www.youtube.com/watch?v=E1Oo_yQYV4U

https://www.youtube.com/watch?v=uFyv8pOC24Y

Lecture Notes-https://www.ahealthiermichigan.org/2011/01/20/calculating-your-bmi-and-bmr/

Session 5

Lecture Topic- The Food Pyramid.

Lecture Video- https://www.youtube.com/watch?v=0KbA8pFW3tg

Lecture Notes-https://www.slideshare.net/AnaLourdesLpezCastro/food-pyramid-power-point-presentation

Session 6

Lecture Topic- History, Chemistry, Absorption, transport, and storage of Vitamin B complex-Vitamin B1.

Lecture Video- https://www.youtube.com/watch?v=gY9dpLipCRo

Lecture Notes- https://www.slideshare.net/YESANNA/thiamine-b1

Session 7

Lecture Topic- Chemistry, Absorption, transport, and storage of Vitamin B complex-Vitamin B2.

Lecture Video- https://www.youtube.com/watch?v=J8Ut4bToMi4

Lecture Presentation-https://www.slideshare.net/drmsrjt/riboflavin-vitamin-b2

Session 8

Lecture Topic- Chemistry, Absorption, transport, and storage of Vitamin B complex-Vitamin B3.

Lecture Video-https://www.youtube.com/watch?v=vWiizkGt9jA

Lecture Notes- https://www.slideshare.net/gulmuneer7/vitamin-b3-28309302

Session 9

Lecture Topic-Chemistry, Absorption, transport, and storage of Vitamin B complex-Vitamin B6.

Lecture Video- https://www.youtube.com/watch?v=mfE3gF_Bnr0

Lecture Presentation- https://www.slideshare.net/qamrunnisashaikh1997/pyridoxal-vitamin-b6

Session 10

Lecture Topics-Chemistry, Absorption, transport, and storage of Vitamin B complex-Biotin(B7).

Lecture Video- https://www.youtube.com/watch?v=jq5rF7Zq0qs.

Lecture Notes-https://www.slideshare.net/YESANNA/biotin-b7-36047276

Session 11

Lecture Topics- Chemistry, Absorption, transport, and storage of Vitamin B complex-Pantothenic acid (B5).

Lecture Video- https://www.youtube.com/watch?v=YBdaG3gLum8

Lecture Notes- https://www.slideshare.net/jainsaketjain/a-presentation-on-pantothenic-acid-or-b5

Session 12

Lecture Topic- Chemistry, Absorption, transport, and storage of Vitamin B complex-Folic acid (B9).

Lecture Video- https://www.youtube.com/watch?v=90J_a4qpySA

Lecture Notes- https://www.slideshare.net/mprasadnaidu/folic-acid-32810916

Session 13

Lecture Topic- Chemistry, Absorption, transport, and storage of Vitamin B complex-B12 (Cobalamin).

Lecture Video-https://www.youtube.com/watch?v=_-n3LeYF830

https://www.youtube.com/watch?v=7HqHq6n7rwM

Lecture Presentation- https://www.slideshare.net/ShakilChemist/vitamin-b12-57123445

Session 14

Lecture Topics- Fat soluble vitamin (Vitamin A,D,E,K).

Lecture Video-https://www.youtube.com/watch?v=3G_e0tILSmM

Lecture Presentation- https://www.slideshare.net/VishnuReddy85/fat-soluble-vitamines

Session 15

Lecture Topic  Practice- BMR and BMI.

Practice Video- https://www.youtube.com/watch?v=oIdrn7hLbGk

https://www.youtube.com/watch?v=LKZZrJjI_NI

Session 16

Lecture Topic- Cellular Respiration: Aerobic Respiration.

Lecture Video- https://www.youtube.com/watch?v=7J4LXs-oDCU

https://www.youtube.com/watch?v=hDq1rhUkV-g

Lecture Presentation- https://www.slideshare.net/YESANNA/glycolysis-42953283

Session 17

Lecture Topic- Anaerobic Respiration

Lecture Video- https://www.youtube.com/watch?v=6-D1oes63_U

Lecture Notes- https://www.slideshare.net/scuffruff/anaerobic-respiration

Session 18

Lecture Topic- Beta Oxidation of fatty acid.

Lecture Video- https://www.youtube.com/watch?v=slCmrtFHFQQ&t=114s

Lecture Notes- https://www.slideshare.net/YESANNA/betaoxidation-of-fatty-acids

Session 19

Lecture Topic- Transamination and deamination reaction.

Lecture Video-https://youtu.be/-z4NZMtnG4w

Lecture Notes- http://eagri.org/eagri50/BIC101/pdf/lec28.pdf

Session 20

Lecture Topic- Urea Formation and transport.

Lecture Video- https://www.youtube.com/watch?v=ng8823q42JE

https://youtu.be/pG2EJ3wMJD0

https://youtu.be/MAQva6USWEw

Lecture Notes- https://www.slideshare.net/YESANNA/urea-cycle-44200147

Session 21

Lecture Topic- Ketogenesis

Lecture Video- https://youtu.be/sSb3JXmqdRE

https://youtu.be/G7CNGjr73Gg

Lecture Presentation- https://www.slideshare.net/YESANNA/ketone-bodies-metabolism

Session 22

Practice Topic - Molarity and Normality.

Practice Video- https://www.youtube.com/watch?v=C3sZS86tiv4

Session 23

Practice Topic- Stock solution preparation.

Practice Video- https://www.youtube.com/watch?v=5RQbMDfc2BM

Session 24

Practice Topic- Stock and Working solution.

Practice Video- https://www.youtube.com/watch?v=C_Nu0CvC97k

Session 25

Lecture Topic- Biochemical aspects of Hormone: Hormone receptors and intracellular messengers, Adenylate cyclase, protein kinase.

Lecture Video- https://youtu.be/jUwgET9ue2w

https://youtu.be/dfUIhhTJhdY

https://youtu.be/7PcbRny3XJc

Lecture Presentation- https://www.slideshare.net/vydehiveeramalla/cyclic-amp

Session 26

Lecture Topic- Phosphodiesterase and its pathway.

Lecture Video- https://www.youtube.com/watch?v=dhd2fja0LZ4

Lecture Notes- https://www.slideshare.net/nileshkate79/photochemistry-of-vision

Session 27

Lecture Topic- Role of insulin and mechanism of action.

Lecture Video- https://www.youtube.com/watch?v=KunJbPF9iSk.

https://www.youtube.com/watch?v=RbJ0hlf0p9w

Lecture Presentation- https://www.slideshare.net/JuhiArora6/insulin-receptor-and-mechanism-of-signalling

Session 28

Lecture Topic- Role of glucagon and its mechanism of action.

Lecture Video- https://www.youtube.com/watch?v=y9Bdi4dnSlg

Lecture Presentation- https://www.slideshare.net/nileshkate79/glucagon-regulation-of-blood-glucose

Session 29

Lecture Topic- Role of epinephrine and its mechanism of action.

Lecture Video-https://www.youtube.com/watch?v=ejq99wLEMTw

Lecture Presentations- https://www.slideshare.net/boofekoor_0/epinephrine-14289785

Session 30

Practice Topic- Diabetes (Determination of blood glucose by GOD/POD method)

Simulation Link - https://www.youtube.com/watch?v=DyGIvs9zrVA

https://www.youtube.com/watch?v=bAhhIMD3Af0

Case Studies

Case Studies