Biopolymer and Hydrogel
Teacher
Dr. Niladri Sarkar
Category
Core Courses
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Course Name : Biopolymer and Hydrogel
Code(Credit) : CUTM 1421(3-1-0)
Course Objectives
- To introduce students to various classes of biomaterials
- To develop understanding regarding the characteristics of the materials to be used as biomaterials
- To develop the understanding regarding the various applications of biomaterials.
Learning Outcomes
- Students will get introduced to different classes of biomaterials and their applications
- The vast applications of biomaterials will encourage students to explore them in detail and to design and engineer synthetic and natural materials for biomedical applications
- The course would also enable the students to appreciate the role of tissue engineering as a tool to enhance the quality of life
Course Syllabus
Module-I (Fundamentals of biopolymers)
- Definition of biopolymers and types of biopolymers
- Definition of bioplastics and types of bioplastics.
- Description of certain biopolymers like starch, cellulose, chitosan, gelatin, alginate, keratin, fatty acids, lipids, aliphatic polyesters (PLA, PHB).
- Cellulose derivatives and cellulose regenerating processes
- Bio based composites from Soybean oil and Chicken feathers
- Preparation of cellulose nanocrystals from raw cellulose (Practice)
Module-II (Polymer biodegradation and biocomposites)
- Natural biodegradable polymer, synthetic biodegradable polymer and modified naturally biodegradable polymer
- Testing methods of biodegradability [polymer-Enzyme assays, Plate test, Respiratory test, Gas evolution test (CO2 & CH4)]
- Use of biopolymers in composite and bioplastic formation and their application in packaging and medical industries
- Investigation of rate of biodegradation of any sample (biopolymer) through anerobic condition (Practice)
Module-III (Basics of biomaterials)
- Concept of biocompatibility and responsiveness
- Technically important form of polymers (Hydrogel, bioceramics, bioelastomers and membranes)
- Mechanical properties (elasticity, yield stress, ductility, toughness, strength, fatigue, hardness and wear resistance) of biomaterials.
- Polymers used as biomaterials (Silicon rubber, Dacron, poly(methyl methacrylate, polyurethane and cellulose) and their application
- Preparation of peptide hydrogel (Practice)
Module-IV (Surface modification and characterization of biomaterials)
- Surface modification by the use of Corona discharge and plasma processes.
- Surface modification with polymer coatings
- Bulk analysis methods applied to the study of Biomaterials (XRD, FTIR, DSC, TGA etc)
- Surface analysis methods applied to the study of biomaterials (SEM, AFM, etc.)
Module-V (Synthesis and Characterization of hydrogels)
- Introduction to hydrogel and brief historical overview
- Classification of hydrogels based on origin, type of interaction, and ionic/non-ionic characteristics
- Different types of gel forming techniques (Physically and chemically cross-linked hydrogels)
- Characterization of hydrogel by SEM, FTIR, 13-C NMR and BET/mercury porosimetry
- Preparation of thermo-reversible agarose hydrogel for gel electrophoresis technique (Practice)
Module-VI (Properties of Hydrogels)
- Evaluation of swelling behaviors of hydrogels (Swelling capacity and water retention capacity) and kinetic analysis.
- Effect of pH, ionic strength and temperature on swelling properties of hydrogels
- Relationship between morphology and swelling properties
- Mechanical and rheological properties of hydrogel
- Mechanical properties of interpenetrating (IPN) and multi-networking hydrogel
- Shear rheometric test on polyacrylamide hydrogel (Practice)
Module-VII (Applications of Hydrogels)
- Introduction to hydrogel drug delivery systems,
- Targeted drug delivery and controlled delivery systems (pH responsive and glucose responsive delivery)
- Kinetics of Drug Diffusion through hydrogels
- Hydrogels for bone replacement, artificial organs, dental applications
- Hydrogel in agricultural application (controlled delivery of water and micronutrients)
- Drug delivery via hydrogel beads (practice)
Session Plan
Session 1
Definition of biopolymers and types of biopolymers
Reference link
Session 2
Definition of bioplastics and types of bioplastics
Reference link
Session 3
Description of certain biopolymers like starch, cellulose, chitosan, gelatin, alginate, keratin, fatty acids, lipids, aliphatic polyesters (PLA, PHB)
Session 4
Cellulose derivatives and cellulose regenerating processes
Session 5
Bio based composites from Soybean oil and Chicken feathers
Session 7
Natural biodegradable polymer, synthetic biodegradable polymer and modified naturally biodegradable polymer
Reference link
Session 8
Testing methods of biodegradability [polymer-Enzyme assays, Plate test, Respiratory test, Gas evolution test (CO2 & CH4)]
degradation of Cellulose and lignin
Reference link
Session 9
Use of biopolymers in composite and bioplastic formation and their application in packaging and medical industries
Session 10 (Practice 2) 2h
Investigation of rate of biodegradation of any sample (biopolymer) through anerobic condition
Session 11
Concept of biocompatibility and responsiveness
Session 12
Technically important form of polymers (Hydrogel, bioceramics, bioelastomers and membranes)
Session 13
Mechanical properties (elasticity, yield stress, ductility, toughness, strength, fatigue, hardness and wear resistance) of biomaterials
Session 14
Polymers used as biomaterials (Silicon rubber, Dacron, poly(methyl methacrylate, polyurethane and cellulose) and their application
Session 16
Surface modification by the use of Corona discharge and plasma processes
Session 18
Bulk analysis methods applied to the study of Biomaterials (XRD, FTIR, DSC, TGA etc)
Session 19
Surface analysis methods applied to the study of biomaterials (SEM, AFM, etc.)
Reference links
Session 21
Classification of hydrogels based on origin, type of interaction, and ionic/non-ionic characteristics
Reference Link
Session 22
Different types of gel forming techniques (Physically and chemically cross-linked hydrogels
Session 23
Characterization of hydrogel by SEM, FTIR, 13-C NMR and BET/mercury porosimetry
Youtube-Mercury porosimetry-Part 1
Youtube-Mercury porosimetry-Part 2
Youtube-Mercury porosimetry-Part 3
Reference links
Session 24 ( Practice 4) (2h)
Preparation of thermo-reversible agarose hydrogel for gel electrophoresis technique
Session 25
Evaluation of swelling behaviors of hydrogels (Swelling capacity and water retention capacity)
Session 32
Introduction to hydrogel drug delivery systems,Targeted drug delivery and controlled delivery systems (pH responsive and glucose responsive delivery
Session 34
Hydrogels for bone replacement, artificial organs, dental applications
Session 35
Hydrogel in agricultural application (controlled delivery of water and micronutrients)
Session 36 (Practice 6) (2h)
Drug delivery via hydrogel beads along with selection of phytochemicals to the particular disease via "Discovery studio"/Biovia Software
Case Studies
Case Studies
Our Main Teachers
Physical Chemistry, Nanoscience and Nanotechnology, Hydrogels