Cell Biology-CUTM 1124, (Credit-4) T(3)-P (0)-Pj (1)

Objective

• To study cell structure and functions of organelle functions
• Exposure on transportations through cell membrane
• To focus on different receptors and model of signaling
• To introduce the concept of cell signaling

Course outcome

• The course is aimed to make the student understand the basic concept of cell structure, membrane, cellular functions of different types of cell, modes of cellular signaling and signal amplification.
  

  COs	Course outcomes	Mapping COs with POs (High-3, Medium-2, Low-1)
  CO1	Knowledge of different types of cells, and their basic functions. and their interrelated behaviours.	PO1 (3)
  CO2, CO3	Individual and team work: Students will be able to know, how to handle cells, its mitosis and meiosis events, apoptotic events.	PO9 (3)
  CO4	Use of practical approach for cell biology and cancer biology, methodology for cell culture experiments, analysis, and interpretation of data, in molecular biology	PO2 (3)

Module I: Structural organization of cell (4hrs)

An Overview of Cells:History, Cell theory, Structure and Function of Cell and its Organelles: Biological membranes – architecture,  Cell types: prokaryotes vs. eukaryotes;  from single cell to multi-cellular organism; Different molecules of cell- water, salt and mineral ions etc.

https://www.youtube.com/watch?v=t5DvF5OVr1Y

Module II: Cell Organalles(5hrs)

Nucleus - Nuclear envelope, transport across nuclear membrane, Nucleolus, Mitochondria, Chloroplasts, Lysosomes, Gloxysomes and Peroxisomes, endoplasmic reticulum, ribosomes, Golgi complex (Structural organization, function, marker enzymes of the above organelles),

https://www.youtube.com/watch?v=Ffm8JNEzA4o

Module III: Cell division-molecular approach(5hrs)

Cell cycle and its regulation, Cellular communication and cell mobility: Cell cycle: G0/G1, S, G2 and M phages (Cell Division: Mitosis, meiosis and cytokinesis); regulation of cell cycle.

https://www.youtube.com/watch?v=LUDws4JrIiI

Module IV: Cell Junction (4Hrs)

Cell adhesion and roles of different adhesion molecules, gap junctions, Extra- Cellular Matrix (ECM), Cell-cell interaction and cell- ECM interaction, The cytoskeleton, Microtubule- based movement and microfilament -based movement

https://www.youtube.com/watch?v=zZESsZZvhVk

Module V :Cell signalling (5hrs)

Hormones and their receptors, cell surface receptor, signaling through G-protein coupled receptors (G-PCR), Tyrosine Kinase,  signal transduction pathways, second messengers, regulation of signaling pathways, bacterial and plant two-component systems, bacterial chemotaxis,

https://www.youtube.com/watch?v=9sF_h-bAnIE

Module VI : Programmed Cell Death  (4hrs)

Programmed Cell Death (Apoptosis), Intrinsic and Extrinsic apoptotic pathway, Caspase enzyme,

https://www.youtube.com/watch?v=Ft-2LCqmdQY

Module VII: Basics Oncology(4hrs)

Biology and elementary knowledge of development and causes of cancer; Tumor viruses, Oncogenes and tumor suppressor genes,

https://www.youtube.com/watch?v=I9zWGRJXIok