CUTM1648 CONCEPT OF TOXICOLOGY

Code(Credit) : CUTM1648(4-2-0)

Course Objectives

This course aims to build an understanding about the

• Concept of poison and toxic materials
• Study the toxic agents
• Study the risk assessment of toxic agents

Learning objectives

• Get knowledge on different toxic substances and their identification and detection.
• Understanding of analytical methods of toxicology and application of toxicology.

Course Syllabus

Unit 1

Introduction to Toxicology

History, scope and applications Types of Toxicology Principle of Toxicology Mechanism of Toxicology Risk Assessment and Safety evaluation of chemicals.

Unit-II

Disposition and Translocation of Toxicants

Exposure of Toxicants x Translocation of Toxicants Bioaccumulation of Xenobiotics Biotransformation of Xenobiotics Antidotal therapy

Unit-III

Toxic Agents

Toxic effects of Pesticides Toxic effects of Metals Toxic effects of Solvent Toxic effects of Plants Toxic effects of Insects & Animal poisons.

Unit-IV

Analytical Toxicology

Introduction Provision of analytical toxicology services Samples and sampling techniques Choice of analytical method Method implementation, development and validation Quality control and quality assurance Applications of analytical toxicology

Unit V

Applications of Toxicology

Clinical Toxicology, Environmental Toxicology/ Ecotoxicology Forensic Toxicology/ Postmortem Toxicology Industrial/Occupational Toxicology Food Toxicology Behavioral toxicology Preventive toxicology Descriptive Toxicology Mechanistic Toxicology Regulatory Toxicology Genetic Toxicology Systemic Toxicology

Reference Book 

• R. J. Flanagan, A. Taylor, I. D. Watson, R. Whelpton, Fundamental of Analytical Toxicology, 2^nd edition (John Wiley & Sons Ltd., 2007), United States
• Toxicological Chemistry, 1^st edi LVIV–2009, Universitatis Medici Leopoliensis Sigillum. AD 1784.
• K Vij , Textbook of Forensic Medicine and Toxicology: Principles and Practice, Chapter 30 p. 429,     Basic Consideration in Drugs/Chemicals, 5^th edn., (Elsevier, 2011).
• R.C. Gupta, Veterinary Toxicology Basic and Clinical Principles, Chapter 1, 1^st edi., (Elsevier, 2007), USA

Session 1

History, scope and applications of Toxicology

http://www.forensicsciencesimplified.org/tox/Toxicology.pdf

Session 2

Types of Toxicology

https://www.youtube.com/watch?v=VF3-V4buOvs

Session 3

Principle of Toxicology

https://medfreecon.files.wordpress.com/2018/04/principles-of-forensic-medicine-and-toxicology.pdf

Session 4

Mechanism of Toxicology

https://nature.berkeley.edu/~dnomura/pdf/Lecture6Mechanisms3.pdf

Session 5

Risk Assessment and Safety evaluation of chemical

http://apps.who.int/iris/bitstream/handle/10665/44065/WHO_EHC_240_7_eng_Chapter4.pdf;jsessionid=D7587845F45B237A46EF980B36C652FF?sequence=7

Session 5

Exposure of Toxicants

https://ehs.unl.edu/documents/tox_exposure_guidelines.pdf

Session 6

Translocation of Toxicants

https://www.slideshare.net/manojbangadkar/translocation-of-toxicants-127753559

Session 7

Bioaccumulation of Xenobiotics

https://www.researchgate.net/publication/327830173_Bioaccumulation_of_Xenobiotic_Compounds

Session 8

Biotransformation of Xenobiotics

https://www.lkouniv.ac.in/site/writereaddata/siteContent/202004061923052084omkar_zool_biotransformation.pdf

Session 9

Antidotal therapy

https://www.semanticscholar.org/paper/Current-views-on-antidotal-therapy-in-managing-of-Pillay/d98c8d27904a1833df8b898cc7bd0180f3f63b89

Session 9

Toxic effects of Pesticides

Session 10

Toxic effects of Pesticides continue

https://www.researchgate.net/publication/256848318_Harmful_effects_of_pesticides_on_human_health#:~:text=The%20effect%20of%20pesticides%20on,%5B5%5D.%20...

Session 11

Toxic effects of Metals

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427717/

Session 11

Toxic effects of Metals continue

https://www.intechopen.com/chapters/64762

Session 12

Toxic effects of Solvent

https://accesspharmacy.mhmedical.com/content.aspx?bookid=449&sectionid=39910793

Session 13

Toxic effects of Solvent continue

https://accesspharmacy.mhmedical.com/content.aspx?bookid=958&sectionid=53483749

Session 13

Toxic effects of Plants

http://epgp.inflibnet.ac.in/epgpdata/uploads/epgp_content/forensic_science/10._forensic_toxicology/07._organic_poisons__plant_poisons/et/7460_et_7_et.pdf

Session 13

Toxic effects of Plants continue

https://www.researchgate.net/publication/332504726_A_systemic_review_of_vegetable_poisoning_and_challenges_in_management

Session 14

Toxic effects of Plants continue

https://www.slideshare.net/KaleemKhan7/vegetable-irritant-poisoningcastor-abrus-croton

Session 15

Toxic effects of insects

https://www.loyola.edu/explore/magazine/stories/2014/venomous-poisonous-insects-and-spiders

Session 16

Toxic effects of Animal poisons

https://www.intechopen.com/chapters/74217

Session 17

Introduction, Provision of analytical toxicology services

https://www.who.int/ipcs/publications/training_poisons/hospital_analytical_toxicology.pdf

Session 18

Samples and sampling techniques

https://www.questionpro.com/blog/types-of-sampling-for-social-research/

Session 19

Choice of analytical method

http://www.idc-online.com/technical_references/pdfs/chemical_engineering/Selecting_an_Analytical_Method.pdf

Session 20

Method implementation, development and validation

https://www.researchgate.net/publication/265467145_Method_development_and_validation_Skills_and_tricks

Session 21

Quality control and quality assurance

https://www.ipcc-nggip.iges.or.jp/public/gp/english/8_QA-QC.pdf

Session 22

Applications of analytical toxicology

https://www.who.int/ipcs/publications/training_poisons/analytical_toxicology.pdf

Session 22

Clinical Toxicology

https://accesspharmacy.mhmedical.com/content.aspx?bookid=1861&sectionid=146078151

Session 23

Environmental Toxicology/ Ecotoxicology

https://www.researchgate.net/publication/264083566_Ecotoxicology

Session 24

Forensic Toxicology/ Postmortem Toxicology

https://link.springer.com/article/10.1007%2Fs12024-010-9150-4

Session 25

Industrial/Occupational Toxicology

https://journals.sagepub.com/doi/pdf/10.3109/10915818309140666

Session 26

Food Toxicology

http://eta.health.usf.edu/publichealth/HSC4573/SPRING17/Lecture%2011%202017%20%E2%80%93%20Food%20Toxicology%20I_slides.pdf

Session 27

Behavioral toxicology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518939/pdf/envhper00365-0081.pdf

Session 28

Preventive toxicology

https://www.tandfonline.com/doi/abs/10.1080/15287397809529685?journalCode=uteh19

Session 29

Descriptive Toxicology

https://www.cartercenter.org/resources/pdfs/health/ephti/library/lecture_notes/med_lab_tech_students/ln_toxicology_final.pdf

Session 30

Mechanistic Toxicology

http://www.gbv.de/dms/bs/toc/519485866.pdf

Session 31

Regulatory Toxicology

https://www.toxicology.org/education/docs/07262017/RobertsSOTEminentToxLectureSeries2017.pdf

Session 32

Genetic Toxicology

https://www.researchgate.net/publication/257848945_Genetic_toxicology_Findings_and_challenges

Session 33

Systemic Toxicology

https://www.researchgate.net/publication/313889923_Systemic_Toxicology