CUTM 1648 Concepts of Toxicology
Teacher
Dr. Reena C. Jhamtani
Category
Core Courses
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Course Name: Concepts of Toxicology
Code(Credit) : CUTM 1648
FS-MS-S3-P2
(4-2-0)
Course Objective
- Concepts of poison and toxic materials.
- Understanding of toxic agents and their risk assessments
Course Outcomes:
- Get knowledge on different toxic substances and their identification and detection.
- Understanding of analytical methods of toxicology and application of toxicology.
- Ability to detect the drugs by various analytical techniques.
- Ability to detect the poison by various analytical techniques from biological and non-biological matrices.
Course Syllabus
UNIT-I: Introduction to Toxicology
History, scope, and applications
Types of Toxicology
Principle of Toxicology
Mechanism of Toxicology
Risk Assessment and Safety evaluation of chemicals
UNIT-II: Disposition and Translocation of Toxicants
Exposure of Toxicants
Translocation of Toxicants
Bioaccumulation of Xenobiotics
Biotransformation of Xenobiotics
Antidotal therapy
UNIT-III: Toxic Agents
Toxic effects of Pesticides
Toxic effects of Metals
Toxic effects of Solvent
Toxic effects of Plants
Toxic effects of Insects & Animal poisons
UNIT-IV: Analytical Toxicology
Introduction
Provision of analytical toxicology services
Samples and sampling techniques
Choice of analytical method
Method implementation, development, and validation
Quality control and quality assurance
Applications of analytical toxicology
UNIT-V: Applications of Toxicology
- Clinical Toxicology
- Environmental Toxicology/ Ecotoxicology
- Forensic Toxicology/ Postmortem Toxicology
- Industrial/Occupational Toxicology
- Food Toxicology
- Behavioral toxicology
- Preventive toxicology
- Descriptive Toxicology
- Mechanistic Toxicology
- Regulatory Toxicology
- Systemic Toxicology
- Genetic Toxicology
Practical
1. Systematic extraction, isolation, purification and identification of volatile, acidic, basic and neutral drugs by various analytical techniques.
2. Extraction and detection of metallic poisons from biological and non biological matrices.
3. Identification of plant poisons by chemical and microscopic methods.
Reference books:
1. Curry: Analytical Methods in Human Toxicology, Part II, 1986.
2. Casarett & Doll Toxicology: The Basic Science of poisons.
3. Clark, E.G.C.: Isolation and identification of Drugs, 1966
4. Curry, A.S.: Poison Detection in Human Organs, 1976
5. Curry, A.S.: Advances in Forensic Chemical Toxicology, 1972
6. Holfmann, F.G.: Handbook of Drug and Alcohol Abuse.
7. Turner: Drugs & Poisons.
8. Samford : Poisons Their Isolation Identification
9. Stoleman: Progress in Chemical Toxicology.
10. Sunshine, I: Guidelines for Analytical Toxicology Programme, Vol-I, CRC press, 1950.
11. Sunshine, I: Handbook of Analytical Toxicology, press, 1969.
12. Mule, S. J. et al. : Immunoassays for Drugs subjects to ab, CRC Press, 1974
13. Connors, K.: A text book of Pharmaceuticals analysis, Interscince, New York, 1975
Session Plan- Theory
Session II: Types of Toxicology
Session III: Principles of Toxicology
Session IV: Mechanism of Toxicology
Session V: Risk Assessment and Safety Evaluation of Chemicals
Session VII: Translocation of Toxicant
Session VIII: Bioaccumulation of Xenobiotics
Session IX: Biotransformation of Xenobiotic
Session X: Antidotal Therapy
Session XII: Toxic effect of Metals
Session XIII: Toxic effect of Solvents
Session XIV: Toxic effect of Plant
Session XV: Toxic effect of Insect and Animal Poisons
Session XVI: Introduction to Analytical Toxicology
Session XVII: Provision for Analytical Toxicology Services
Session XVIII: Samples and Sampling Techniques
Session XIX: Choice of Analytical Method
Session XX: Method Implementation: Development
Session XX: Method Implementation: Validation
Session XXI: Quality Control and Quality Assuarance
Session XXII: Applications of Analytical Toxicology
Session XXIII: Clinical Toxicology
Session XXIV: Environmental Toxicology and Ecotoxicology
Session XXV: Forensic Toxicology/ Postmortem Toxicology
Session XXV: Industrial Toxicology/ Occupational Toxicology
Session XXVI: Food Toxicology
Session XXVII: Preventive Toxicology
Session XXVIII: Descriptive Toxicology
Session XXIX: Mechanistic Toxicology
Session XXX: RegulatoryToxicology
Session XXXI: Genetic Toxicology
Session XXXII: Systemic Toxicology
Session Plan- Practical
Session I:
Systematic extraction, isolation, purification and identification of volatile drugs by various analytical techniques.
Session II:
Systematic extraction, isolation, purification and identification of acidic drugs by various analytical techniques.
Session III:
Systematic extraction, isolation, purification and identification of Basic drugs by various analytical techniques.
Session IV:
Systematic extraction, isolation, purification and identification of neutral drugs by various analytical techniques.
Session V:
Extraction and detection of metallic poisons from biological and non biological matrices.
Our Main Teachers
Associate Professor at the School of Forensic Sciences, Centurion University of Technology and Management, Orrisa, Bhubaneshwar.