CUTM 1648 Concepts of Toxicology

Teacher

Dr. Reena C. Jhamtani

Category

Core Courses

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Course Name: Concepts of Toxicology

Code(Credit) : CUTM 1648

                            FS-MS-S3-P2

                            (4-2-0)

Course Objective

  • Concepts of poison and toxic materials.
  • Understanding of toxic agents and their risk assessments

Course Outcomes:

  • Get knowledge on different toxic substances and their identification and detection.
  • Understanding of analytical methods of toxicology and application of toxicology.
  • Ability to detect the drugs by various analytical techniques.
  • Ability to detect the poison by various analytical techniques from biological and non-biological matrices.

Course Syllabus

UNIT-I: Introduction to Toxicology
History, scope, and applications
Types of Toxicology
Principle of Toxicology
Mechanism of Toxicology
Risk Assessment and Safety evaluation of chemicals

UNIT-II: Disposition and Translocation of Toxicants
Exposure of Toxicants
Translocation of Toxicants
Bioaccumulation of Xenobiotics
Biotransformation of Xenobiotics
Antidotal therapy

UNIT-III: Toxic Agents
Toxic effects of Pesticides
Toxic effects of Metals
Toxic effects of Solvent
Toxic effects of Plants
Toxic effects of Insects & Animal poisons

UNIT-IV: Analytical Toxicology
Introduction
Provision of analytical toxicology services
Samples and sampling techniques
Choice of analytical method
Method implementation, development, and validation
Quality control and quality assurance
Applications of analytical toxicology

UNIT-V: Applications of Toxicology

  • Clinical Toxicology
  • Environmental Toxicology/ Ecotoxicology
  • Forensic Toxicology/ Postmortem Toxicology
  • Industrial/Occupational Toxicology
  • Food Toxicology
  • Behavioral toxicology
  • Preventive toxicology
  • Descriptive Toxicology
  • Mechanistic Toxicology
  • Regulatory Toxicology
  • Systemic Toxicology
  • Genetic Toxicology

Practical
1. Systematic extraction, isolation, purification and identification of volatile, acidic, basic and neutral drugs by various analytical techniques.
2. Extraction and detection of metallic poisons from biological and non biological matrices.
3. Identification of plant poisons by chemical and microscopic methods.

Reference books:
1. Curry: Analytical Methods in Human Toxicology, Part II, 1986.
2. Casarett & Doll Toxicology: The Basic Science of poisons.
3. Clark, E.G.C.: Isolation and identification of Drugs, 1966
4. Curry, A.S.: Poison Detection in Human Organs, 1976
5. Curry, A.S.: Advances in Forensic Chemical Toxicology, 1972
6. Holfmann, F.G.: Handbook of Drug and Alcohol Abuse.
7. Turner: Drugs & Poisons.
8. Samford : Poisons Their Isolation Identification
9. Stoleman: Progress in Chemical Toxicology.
10. Sunshine, I: Guidelines for Analytical Toxicology Programme, Vol-I, CRC press, 1950.
11. Sunshine, I: Handbook of Analytical Toxicology, press, 1969.
12. Mule, S. J. et al. : Immunoassays for Drugs subjects to ab, CRC Press, 1974
13. Connors, K.: A text book of Pharmaceuticals analysis, Interscince, New York, 1975

Session Plan- Theory

Session I: History, scope, and applications

module-1

History and Scope of Toxicology

Session II: Types of Toxicology

Types of Toxicology

Session III: Principles of Toxicology

Principles of Toxicology

Session IV: Mechanism of Toxicology

Mechanism of Toxicology

Session V: Risk Assessment and Safety Evaluation of Chemicals

Risk Assessment

Session VI: Exposure of Toxicants

EXPOSURE OF TOXICANT

tox_exposure_guidelines

Session VII: Translocation of Toxicant

Translocation of toxicants

Session VIII: Bioaccumulation of Xenobiotics

bioaccumulation of xenobiotics

Session IX: Biotransformation of Xenobiotic

biotransformation of xenobiotics

Session X: Antidotal Therapy

antidotal theory

Session XI: Toxic effect of pesticides

PESTICIDE

PESTICIDE EFFECT

Session XII: Toxic effect of Metals

Toxic Effects of Metals

Session XIII: Toxic effect of Solvents

Toxic Effects of Solvents and Vapors

Session XIV: Toxic effect of Plant

Toxic Effects of Plants, Fungi, and Algae

Session XV: Toxic effect of Insect and Animal Poisons

Toxic Effects of Terrestrial Animal Venoms and Poisons

Session XVI: Introduction to Analytical Toxicology

ANALYTICAL TOXICOLOGY

Analytic_Forensic Toxicology

Session XVII: Provision for Analytical Toxicology Services

Provision of Analytical toxicology

Session XVIII: Samples and Sampling Techniques

Session XIX: Choice of Analytical Method

Session XX: Method Implementation: Development

Session XX: Method Implementation: Validation

Validation

Session XXI: Quality Control and Quality Assuarance

Session XXII: Applications of Analytical Toxicology

Session XXIII: Clinical Toxicology

CLINICAL TOXICOLOGY

Session XXIV: Environmental Toxicology and Ecotoxicology

Environmental

Session XXV: Forensic Toxicology/ Postmortem Toxicology

Postmortem Toxicology

Session XXV: Industrial Toxicology/ Occupational Toxicology

Industrial-occupational toxicology (2)

Session XXVI: Food Toxicology

Food toxicology

Session XXVI: Behavioural Toxicology

BEHAVIOURAL TOXICOLOGY 1

BEHAVIOURAL TOXICOLOGY

Session XXVII: Preventive Toxicology 

Preventive toxicology

Session XXVIII: Descriptive Toxicology

DISCRIPTIVE TOXICOLOGY

Session XXIX: Mechanistic Toxicology

Mechanistic Toxicology ( PDFDrive )

Session XXX:  RegulatoryToxicology

Regulatory toxicology

Session XXXI: Genetic Toxicology

Genetic Toxicology

Session XXXII: Systemic Toxicology

Systemic toxicology

Session Plan- Practical

Session I:

Systematic extraction, isolation, purification and identification of volatile drugs by various analytical techniques.

Volatile Poison.docx

Session II:

Systematic extraction, isolation, purification and identification of acidic drugs by various analytical techniques.

Acidic Poison.docx

Session III:

Systematic extraction, isolation, purification and identification of Basic drugs by various analytical techniques.

Basic Poison

Session IV:

Systematic extraction, isolation, purification and identification of neutral drugs by various analytical techniques.

Neutral Poison

Session V:

Extraction and detection of metallic poisons from biological and non biological matrices.

Metallic Poison

Session VI:

Identification of plant poisons by chemical and microscopic methods.

Plant Poison.docx

Session VII:

Identification of  anions by chemical methods.

Non-Metallic Poison.docx

Our Main Teachers

Associate Professor at the School of Forensic Sciences, Centurion University of Technology and Management, Orrisa, Bhubaneshwar.

VARSHA SINGH

Assistant Professor
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