Course: Pharmacology-Phyto

Code (Credit): CUTM1171 (2-1-0)

Course Objective

The student will be able to identify a range of drugs used in medicine and discuss their mechanisms of action, leading to skill improvement.

Course Outcomes

1. Students will understand the term drug and its route of delivery. (PO1)
2. They will also understand the pharmacological action of various categories of drugs. (PO2, PO3)

Course Syllabus

Module I: Pharmacology basics and CNS drugs (8h + 6h)

• Theory: Introduction, Definition & scope of Pharmacology and Principles of general Pharmacology, Route of Drug Administration, Brief Knowledge of following - CNS depressants, Sedatives, Antiepileptic.
• Practice: (Virtual Lab: http://heb-nic.in/Ex-Pharm)

1. 1. Introduction to experimental pharmacology.
   2. Commonly used instruments in experimental pharmacology.
   3. Study of common laboratory animals.
   4. Maintenance of laboratory animals as per CPCSEA guidelines.
   5. Common laboratory techniques. Blood withdrawal, serum and plasma separation, anesthetics and euthanasia used for animal studies.
   6. Study of different routes of drugs administration in mice/rats.

Module II: Different classes of drugs and their pharmacology (3h + 2h)

• Theory: Brief Knowledge of following - Antipyretics, Analgesics, Antihypertensive, Anticoagulant, Haemopoetic,
• Practice: (Virtual Lab: http://heb-nic.in/Ex-Pharm)

1. 1. Study of effect of hepatic-microsomal enzyme inducers on the phenobarbitone sleeping time in mice.
   2. Effect of drugs on ciliary motility of frog oesophagus.
   3. Effect of drugs on rabbit eye.

Module III: Different classes of drugs and their pharmacology II (3h + 2h)

• Theory: Brief Knowledge of following -Bronchodialators, Expectorants, Digestants, Antacids, Laxatives.

• Practice: (Virtual Lab: http://heb-nic.in/Ex-Pharm)

1. 1. Effects of skeletal muscle relaxants using rota-rod apparatus.
   2. Effect of drugs on locomotor activity using actophotometer.
   3. Anticonvulsant effect of drugs by MES and PTZ method.

Module IV: Pharmacology of different classes of drugs and posology (6h + 2.5h)

• Theory: Brief Knowledge of following - Diuretic, Antidiabetic, steroids, Contraceptives, Antibiotics, Aoushadha Suvan kala, Anupana- its importance, Posology.
• Practice: (Virtual Lab: http://heb-nic.in/Ex-Pharm)

1. 1. Study of stereotype and anti-catatonic activity of drugs on rats/mice.
   2. Study of anxiolytic activity of drugs using rats/mice.
   3. Study of local anaesthetics by different methods.

Suggested Readings

1. 1. Harvey, R. A., Clark, M., Finkel, R., Rey, J., & Whalen, K. (2012). Lippincott’s illustrated reviews: Pharmacology. Philadelphia.
   2. Katzung, B. G. (2012). Basic and clinical pharmacology. Mc Graw Hill.
   3. Dale, M. M., & Haylett, D. G. (2013). Rang & Dale's Pharmacology Flash Cards Updated Edition E-Book. Elsevier Health Sciences.
   4. Tripathy, K. D. (2018). Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers.

Session Plan

Session 1 (Theory)

Introduction, Definition & scope of Pharmacology and Principles of general Pharmacology (Drug receptor interactions Video , Scope of pharmacology PPT)

Session 2 (Practice)

Introduction to experimental pharmacology (Virtual Lab)

Session 3 (Theory)

Route of Drug Administration (Route of Drug Administration Video , Route of Drug Administration PPT)

Session 4 (Practice)

Commonly used instruments in experimental pharmacology (Virtual Lab)

Session 5 & 6 (Theory)

Drugs acting on Central Nervous System (CNS Drugs Video , CNS Drugs 2 , Drugs acting on CNS PPT)

Session 7 (Practice)

Study of common laboratory animals. (Virtual Lab)

Session 8 (Theory)

Drugs acting on Central Nervous System: Depressants. (CNS Depressants Video, CNS depressants PPT)

Session 9 (Practice)

Maintenance of laboratory animals as per CPCSEA guidelines. (Virtual Lab)

Session 10 (Theory)

Drugs acting on Central Nervous System: Sedatives. (Sedative Video , Sedatives Hhypnotics PPT)

Session 11 (Practice)

Common laboratory techniques. Blood withdrawal, serum and plasma separation, anesthetics and euthanasia used for animal studies. (Virtual Lab)

Session 12 (Theory)

Drugs acting on Central Nervous System: Antiepileptic. (Antiepileptic Video , Antiepileptic PPT)

Session 13 (Theory)

NSAIDs: Analgesic and Antipyretic. (NSAID Video , NSAIDs PPT)

Session 14 (Practice)

Study of effect of hepatic-microsomal enzyme inducers on the phenobarbitone sleeping time in mice. (Virtual Lab)

Session 15 (Theory)

Pharmacology of Antihypertensive drugs. (Antihypertensive Video , Antihypertensive Drugs PPT)

Session 16 (Practice)

Effect of drugs on ciliary motility of frog oesophagus. & Effect of drugs on rabbit eye. (Virtual Lab)

Session 17 (Theory)

Pharmacology of Anticoagulant, Haemopoetic drugs. (Coagulation Cascade Animation Video, Anticoagulants PPT)

Session 18 (Practice)

Effects of skeletal muscle relaxants using rota-rod apparatus. (Virtual Lab)

Session 19 (Theory)

Pharmacology of Bronchodilator drugs. (COPD and Bronchial constriction Video , Antiasthmatics Drugs PPT)

Session 20 (Theory)

Pharmacology of Expectorants. (Guaifenesin MOA Video , Cough suppressants & expectorants)

Session 21 (Practice)

Anticonvulsant effect of drugs by MES and PTZ method. (Virtual Lab)

Session 22 (Theory)

Pharmacology of Digestants. (Digestant Video , Digestants PPT)

Session 23 (Theory)

Pharmacology of Antacids, & Laxatives. (Proton Pump Animation , Laxatives PPT , Antacid PPT )

Session 24 (Theory)

Pharmacology of Diuretic. (MOA of Diuretics Video , Diuretics PPT)

Session 25 (Practice)

Study of stereotype and anti-catatonic activity of drugs on rats/mice. Study of anxiolytic activity of drugs using rats/mice. (Virtual Lab)

Session 26 (Theory)

Pharmacology of Antidiabetic, steroids, Contraceptives, Antibiotics, Aoushadha Suvan kala, Anupana- its importance, Posology. (Diabetese Video , Antidiabetics PPT)

Session 27 (Theory)

Pharmacology of Steroids and Contraceptives. (Contraceptives MOA, Steroids and Contraceptives PPT)

Session 28 (Theory)

Pharmacology of Antibiotics. (Antibiotic MOA, Pharmacology of antibiotics PPT)

Session 29 (Practice)

Study of local anaesthetics by different methods. (Virtual Lab)

Session 30 (Theory)

Aoushadha Suvan kala, Anupana- its importance, Posology. (Aoushadha Suvan kala Video , Aoushadha Suvan kala, Anupana Blog ,  Posology PPT )

Question Bank

Assignments

Laboratory Manual

Lecture Notes