Domain Track: Nutraceuticals
Teacher
Preetha Bhadra
Category
Domain Courses
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Track Total Credits ( T-P-P): 3-9-17
Courses Division( list all divisions):
Track courses (3-6-0)
- Introduction to Nutraceutical (1+2)
- Functional Food (1+2)
- Nutrigenetics (1+2)
Project Courses (0-3-6)
- Development of Personalized Food and Medicine (0-1-2)
- Development of Biopesticides and Biofertilizers (0-1-2)
- Development of Immune Boosters (0-1-2)
AELP Linked Project Courses (0-0-11) (For Agriculture Students only)
- To develop personalized food and beverages rich in Antioxidants and Polyphenols
- To Develop low-cost omega-3 capsules from fish oil that can reduce inflammation and improve hypertriglyceridemia
- To develop immune boosters
- To develop energy bars
- Development and Application of different pesticides and fertilizers in Organic farm
- Development and Application of pesticides in fishes
- Development and Application of drug designing in lab
- Products/Patents/Publications
Course Objectives:
- To study the advantages of functional foods over conventional Medicine to avoid potential side-effects.
- To Study about dietary supplements and food gene interface
- To distinguish between food, functional food, and supplements
- To learn about Drug Designing, and detailed Protein structure, pharmacophore, basics of Docking and Discovery studio and application in Agriculture, Fisheries and other Sciences
CO-PO Mapping:
| COs | Course Outcome | POs |
| CO1 | To understand Functional foods and their effects on human health and the role of antioxidants, polyphenols, omega-3 fatty acids, to prevent different physiological disorders. | PO1, PO2 |
| CO2 | To Understand the importance of personalized food with respect to nutrigenetics. | PO1 |
| CO3 | To be able to design a drug molecule and identify its applications. | PO2, PO7, PO9 |
| CO4 | To be able to analyze nanomaterials and use it as Bio-Pesticides and Biofertilizers, | PO2, PO7, PO9 |
| CO5 | To be able to illustrate the structure of Protein, Pharmacophores | PO2, PO7, PO9 |
PO1 : Knowledge Enhancement : Demonstrate knowledge and understanding of essential facts, concepts, principles and theories relating to Soil Science, Agronomy, Horticulture, Genetics and Plant Breeding, Plant Pathology, Entomology and other such areas of agriculture.
PO2 : Professional Enhancement : Understanding the value and processes of life-long learning and professional development.
PO7 : Data Handling : Collect, analyze and interpret scientific data.
PO8 : Ethics : Apply ethical principles and commit to professional ethics and responsibilities and norms of the scientific practice.
PO9 : Computational Skills : Recognize, analyze problems and plan strategies for their solutions with the help of computer skills.
Domain Syllabus:
Projects and Products Validation: (3+17) (AELP linked)
- Develop personalized food and beverages rich in Antioxidants and Polyphenols
- Develop low-cost omega-3 capsules from fish oil that can reduce inflammation and improve hypertriglyceridemia
- Develop immune boosters
- Develop energy bars
- Extraction of Antioxidants and Polyphenols from different sources. (eg: Ramie, Dragon Fruit, Berries)
Subject 1: Introduction to Nutraceutical (1+2)
Theory:
Organizational elements, classification of nutraceuticals, dietary supplements, fortified foods, functional foods, and Phyto-nutraceuticals. The scope involved in the industry, Indian, and global scenario, Food Chemistry, Preservatives, food colors.
Practicals:
- Milk Analysis: Determination of fat, acidity, lactose, protein, adulterants
- Analysis of water: Collection of the sample, preliminary examination, Total soluble solids, Determination of total hardness, chlorides, dissolved oxygen
- Analysis of fats: acid value, saponification value, iodine number, antioxidants
- Analysis of foods: Determination of reducing and non reducing sugar, protein, determination of ash/total protein/moisture in dietary fibers
- Anti-nutritional Factors: Trypsin inhibitor, Phytic acid, Antifungal activity of cystatin
- Vitamins: Ascorbic acid by colorimetric method, estimation of Vit A/E
- Pigments: Curcumin, chlorophyll, carotene
Subject 2: Functional Food (1+2)
Theory:
- Prebiotics- Definition, chemistry, sources, metabolism and bioavailability, the effect of processing, physiological effects, effects on human health, and potential applications in risk reduction of diseases. perspective for food applications for the – Non-digestible carbohydrates/oligosaccharides, Dietary fiber, Resistant starch, Gums.
- Probiotics- Taxonomy and important features of probiotic microorganisms. Health effects of probiotics including mechanism of action. Probiotics in various foods: fermented milk products, non-milk products, etc. Quality Assurance of probiotics and safety.
- Drug Discovery - Issues, Target and Lead Identification, Drug And Databases, Drug Properties, Drug Solubility/permeability, ADME, Molecular Modelling, Quantitative Structure-Activity Relationship, Target-based drug design, Docking. Pharmacokinetics/ pharmacodynamics, Discussion on Molecular Drug Designing, Targeted drug designing, Application
Practicals:
- Extraction Techniques: Soxhlet Extraction, Cold Press Extraction, Super Critical Fluid Extraction, CO2 Extraction
- Isolation and Purification of Phytochemicals: TLC, Paper Chrom, Column Chrom, HPLC, Analysis of Aflatoxin
- Validation of Phytochemicals: Using different microorganisms and mammalian cell lines
Subject 3: Nutrigenetics (1+2)
Theory:
Introduction to Nutrigenetics, Nutrigenomics, Concept of Personalized food with special references to athletes. Introduction to different types of public domain databases, data mining strategies, primer designing.
Practical:
- m-RNA extraction from treated mammalian cell line
- Preparation of c-DNA
- Study of Gene expression in Real Time PCR
- Electrophoresis
Domain Books:
Introduction to Nutraceuticals:
- Giuseppe Mazza; Functional Foods: Biochemical and Processing Aspects, Volume 1; CRC Press
- Robert E.C. Wildman; Handbook of Nutraceuticals and Functional Foods, Second Edition; CRC Press
- Massimo Maffei; Dietary Supplements of Plant Origin; CRC Press
- Fereidoon Sahidi, Deepthi K. Weerasinghe; Nutraceutical Beverages, Chemistry, Nutrition and Health Effects; American Chemical Society
Functional Foods:
- Ronald R. Watson; Vegetables, Fruits, and Herbs in Health Promotion; CRC Press
- Fruit and Cereal Bioactives: Sources, Chemistry and Applications; ÖzlemTokusoglu; Clifford Hall III; CRC Press
- Susan Sungsoo Cho, Mark L. Dreher; Marcel; Dekker Handbook of Dietary Fibre
Nutrigenetics:
- Principles of Nutrigenetics and Nutrigenomics - 1st Edition. Print Book & E-Book. ISBN 9780128045725, 9780128045879.
- Nutrigenetics: Applying the Science of Personal Nutrition. Academic Press; Reprint edition (19 August 2016).
- Nutrigenetics and Nutrigenomics. World Review of Nutrition and Dietetics, Vol. 93
Development of Personalized Food and Medicine
Textbook of Personalized Medicine. Authors: Jain, K. K. Springer Publication
Development of Biopesticides and Biofertilizers
Biofertilizers and Biopesticides Paperback – 29 June 2019 by Krishnendu Acharya (Author), Surjit Sen (Author), Manjula Rai (Author)
Biofertilizer and Biopesticide Hardcover – 1 March 2011, by Shalini Suri (Author)
Development of Immune Boosters
Immune System: How To Boost The Immune System Naturally by Elizabeth Grace
Session Plan: 1.1.1a.
Organizational elements
Session Plan: 1.1.1c.
Dietary supplements, fortified foods
Session Plan: 1.1.1d.
Phyto-nutraceuticals
Session Plan: 1.1.2a.
Milk Analysis: Determination of fat, acidity, lactose, protein, adulterants
Session Plan: 1.1.2b.
Analysis of water: Collection of the sample, preliminary examination, Total soluble solids, Determination of total hardness, chlorides, dissolved oxygen
Session Plan: 1.1.2c.
Analysis of fats: acid value, saponification value, iodine number, antioxidants
Session Plan: 1.1.2d.
Analysis of foods: Determination of reducing and non-reducing sugar, protein, determination of ash/total protein/moisture in dietary fibers
Session Plan: 1.1.2e.
Anti-nutritional Factors: Trypsin inhibitor, Phytic acid, Antifungal activity of cystatin
Session Plan: 1.1.2f.
Vitamins: Ascorbic acid by colorimetric method, estimation of Vit A/E
Session Plan: 1.2.1a.
Probiotics &Prebiotics-Definition, chemistry, source
New Scientific Paradigms for Probiotics and Prebioticshttps://www.youtube.com/watch?v=fJWFv0REa1A
Session Plan: 1.2.1b.
Effect of processing, physiological effects
Session Plan: 1.2.1c.
Perspective for food applications for the – Non-digestible carbohydrates/ oligosaccharides, Dietary fiber, Resistant starch, Gums
Session Plan: 1.2.1d.
Probiotics- Taxonomy and important features of probiotic microorganisms
Probiotic Introduction
Session Plan: 1.2.1e.
Health effects of probiotics including mechanism of action
Session Plan: 1.2.1h.
Different types of Prebiotics
Session Plan: 1.2.1i.
Role of Functional Foods in diabetes, gut health, obesity, cancer, neurodegenerative diseases, etc
https://www.youtube.com/results?search_query=PERSONALISED+FOOD
Session Plan: 1.2.2a.
Extraction Techniques
https://www.youtube.com/watch?v=NgsuPTLkPgs
Soxhlet Extraction
https://www.youtube.com/watch?v=mLq35x0g46g
Cold Press Extraction
https://www.youtube.com/watch?v=ONSw77LMSyI
Super Critical Fluid Extraction
Session Plan: 1.2.2b.
Isolation and Purification of Phytochemicals
https://www.youtube.com/watch?v=SnbXQTTHGs4
TLC
https://www.youtube.com/watch?v=e3lRt9XdV0s
Paper Chromatography
https://www.youtube.com/watch?v=23W5Z_redfs
Column Chromatography
https://www.youtube.com/watch?v=i8IT_fzNOOY
Gas Chromatography
https://www.youtube.com/watch?v=4Xaa9WdXVTM
HPLC
https://www.youtube.com/watch?v=ZN7euA1fS4Y
Analysis of Aflatoxin
Session Plan: 1.2.2c.
Validation of Phytochemicals: Using different microorganisms and mammalian cell lines
Session Plan: 1.3.1a.
Introduction to Nutrigenetics
Session Plan: 1.3.1b.
Introduction to Nutrigenomics
Session Plan: 1.3.1c.
Different types of “omics” study – the basic idea
Different types of “omics” study – basic idea
References: https://www.labroots.com/trending/cancer/11894/five-omics-fields-introduced
Session Plan: 1.3.1d.
Human Genome Project
Session Plan: 1.3.1e.
Central dogma – basic concepts
Session Plan: 1.3.1f.
Concept of Personalized food with special references to athletes
Session Plan: 1.3.1g.
Introduction to different types of primer designing
Session Plan: 1.3.1h.
Gene expression, upregulation, and downregulation of genes
Session Plan: 1.3.1i.
Genes associated with metabolic disorders
Session Plan: 1.3.1j.
Understanding Food – gene interface (based on recent research publications)
Session Plan: 1.3.2a.
m-RNA extraction from treated mammalian cell line
Session Plan: 1.3.2c.
Study of Gene expression in Real Time PCR
Session Plan: 1.3.2d.
Electrophoresis
https://www.jove.com/video/3923/agarose-gel-electrophoresis-for-the-separation-of-dna-fragments
List of Projects/ papers/jobs/products to be done in domain:
2. Projects
2.1. To develop personalized food and beverages rich in Antioxidants and Polyphenols
This project includes the extraction of phytochemicals, identification of bioactive compound(s), isolation of this compound, and incorporation in food/beverages. This food/beverages will be specific for people suffering from hyperglycemia, obesity, or may target athletes to provide instant energy.
2.2. To develop low-cost omega-3 capsules from fish oil/ walnuts
PUFAs like omega-3 fatty acids found in fish oil, walnuts can reduce inflammation and improve hypertriglyceridemia. Formulation of this type of capsule involves drug designing (using Discovery Studio, Biovia) and clinical trials.
2.3. To develop immune boosters
Immune boosters are most suitable for children below 10 years and the aged person above 60 years. This will strengthen the internal immunity of the body and will help to combat the common cold viruses, cases of flu, etc.
2.4. To develop protein bars
Protein bars are popular among the young generation as they are healthy and tasty. Low-calorie protein bars, rich with fruits and nuts may be a popular product with high market value. The level of carbohydrate, fats, proteins, vitamins need to be standardized and hence basic food biochemistry analysis will be involved.
2.5. To develop the extraction of antioxidants and polyphenols from different sources
SCFE (using carbon dioxide) of antioxidants and polyphenols from different sources (eg: Ramie, Dragon Fruit, Berries) can be performed in Gram Tarang Foods Pvt. Ltd. Besides, soxhlet, cold press methods can be explored for finding a commercial way of extraction and supplying it to different food/beverage companies. This project could be beneficial for getting the monetary benefits as well as getting publication by studying the biological efficacy of the plant extracts.
2.6. In-silico Validation of the Phytochemicals on Fish cell line and Plant Microbes
The bioactive molecules from phytochemicals can be used against different types of plant pathogens as well as can be used as fish feed to protect from bacterial or fungal action. This will include molecular docking, pharmacophore modelling. In- silico models will be validated using wet lab tests. Quality publications are expected.
2.7. Drug Designing
Known bioactive molecules from natural resources will be used for drug designing against different human physiological disorders, such as, Hypertension, Hyperglycemia, Parkinson’s disease and certain metabolic disorders. Validation of the drugs warrants clinical trial and may lead to patent and publications.
2.8. In-silico Validation of Nanoparticle dosages on Fish Cell Line and Plant Microbes
Studies on nanoparticles and its applications in plant pathology and fishery sciences are gaining immense popularity. In-silico models will can provide proper experimental design to many research works related to fisheries and plant pathology that would save time, money and man power. Validation of in-silico data in wet lab may lead to quality publications.
3. Products/Patents/Publications
All of the above projects ultimately lead to product development and a decent amount of quality publications. Project (1) and (2) have a high potential to get patents if the proper clinical trials can be conducted.
List of Assignments:
- Value addition of chocolates
- The relation between human genetics and food
- Medication: In light of the personalized medicine
- Indigenous medicinal plants as functional foods
- Indigenous medicinal plants as immunoboosters
- Indigenous medicinal plants as Biopesticides and Biofertilizers
Our Main Teachers
PhD in Biophysics, currently working as an Assistant Professor in the Department of Biotechnology. My current working field is the uses of different Medicinal plants and spices and their application in Agriculture and Lifesciences, Drug designing. I love to take challenges and work hard to complete that. New domains and areas of my venture are […]
Present Position Assistant Professor, Dept. of Biochemistry and Plant Physiology, MSSSoA, Centurion University of Technology & Management, Odisha, India Mobile: 9330492088 , E-mail: pradipta.banerjee@cutm.ac.in Education Bachelor of Science (Biotechnology), PES College, Bangalore University, Karnataka, India Master of Science (Biochemistry), Vidya Sagar University, West Bengal, India Ph.D. (Soil Sc. & Agri. Chemistry), Visva Bharati University, Birbhum, […]