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Module - 1: Principles of Inheritance (5 h)
Laws of heredity, Co-and incomplete dominance, Gene Linkage and crossing over, Varieties of Gene interractions - lethal genes, multiple alleles, pleiotropic genes, gene epistasis, Structural and numerical alterations of chromosomes and meiotic consequence, Cytoplasmic Inheritance , Sex-chromosome systems; Different mechanisms of sex determination in animals(Drosophila, Man, Bees and Bonellia)
Gene Interaction and Sex Determination in animals
Module - 2: Linkage and Crossing over in diploid organisms (5 h)
Sex linkage: Sex linked genes in man, sex chromosome disorders in man, Detection of linkage & Linkage maps: Test cross, test for linkage on the basis of F2 generation, LOD score, gene mapping, three point test cross in Drosophila, construction of linkage maps, Identification of particular linkage groups with specific chromosome, Physical distance and map distance, Interference and coincidence
Two point and Three point Test cross
Module - 3: Mitotic recombination and Chromosomal abnormalities (4 h)
Mitotic Recombination, Recombination within gene, Spontaneous and induced mutations, physical and chemical mutagens, chromosomal aberrations, meiotic behaviour of deletion, duplication, inversion and translocation, Euploids and aneuploids-classification, origin, induction, role of polyploidy in evolution.
Preparation of Mitotic chromosomes from the given sample
Module - 4: Human genetics and Genomics (5 h)
Human genetics - Chromosomal disorder, Some common human syndromes, Twin study, Superfoetation, Polyembryony, Free Martin, Multiple birth, Amniocentesis and Genetic Counselling, Nature and function of genetic material, Chemical compounds causing genetic damage, Gene mapping and genome analysis.
To study the karyotyping of chromosomes from the given animal samples.
Chromosomal disorders and human syndromes
Module - 5: Epigenetics and Chromatin structures (4 h)
Epigenetics vs Genetics, Epigenetics from phenomena to field : overview and concepts, Basic organization of eukaryotic genome, Histone proteins.
Chromatin structure and Histone protein
Module - 6: Epigenetic marks and chromatin modifications (5 h)
Histone modifications and the histone code, Chromatin remodelling complex and histone variants, DNA Methylation, Acetylation and Deacetylation, Phosphorylation, Ubiquitylation, Deubiquitylation and Phosphorylation.
Module - 7: Dosage compensation and Genomic imprinting (4 h)
Dosage compensation in mammals, Genomic imprinting in mammals, Germline and pleuripotent stem cells, Epigenetics and human disease.
Epigenetics and human disease
Reference and Textbooks
Varieties of Gene interractions - lethal genes, multiple alleles, pleiotropic genes, gene epistasis
You tube link 1 : Genetic epistasis
You tube link 2 : Pleiotropy
|Cytoplasmic Inheritance , Sex-chromosome systems; Different mechanisms of sex determination in animals(Drosophila, Man, Bees and Bonellia)|
Online source :1. Mechanism of sex determination
Online source :2. Cytoplasmic Inheritance
You tube link : 1. Sex Determination
You tube link : 2.Sex Linkage and Cytoplasmic Inheritance
Spontaneous and induced mutations, physical and chemical mutagens
Chromosomal aberrations, meiotic behavior of deletion, duplication, inversion and translocation.
You tube link: Chromosomal aberrations
Euploids and aneuploids-classification, origin, induction, role of polyploidy in evolution .
You tube link: 1- Changes in chromosome number (Euploidy and Aneuploidy)
You tube link: 2-Euploidy, polyploidy part -1
Epigenetics from phenomena to field : overview and concepts
coursera source : Introduction to the concepts of epigenetic control
Online source: Concept of Epigenetics
You tube link : Epigenetics Overview
Practice - 3 (2 h)
To study the chromatin modelling and Chromatin-immunoprecipitation (ChIP)
Online source 1: Extraction, purification and analysis of histones
Online source 2: Extracting histones for the specific purpose of label-free MS
Youtube source 2: Separating Proteins using SDS Polyacrylamide Gel Electrophoresis
Phosphorylation, Ubiquitylation, Deubiquitylation and Phosphorylation
You tube link : What is ubiquitin?
Practice -5 (2h)
Isolation of nuclei (as a source for studies on structure of chromatin) from rat/mouse liver by discontinuous sucrose-density gradient centrifugation.
You Tube Link : Sucrose Density Gradient High Speed Centrifugation
Associate Professor, Department of Zoology (School of Applied Sciences) CUTM – Bhubaneswar Dr. Yashaswi Nayak presently serving in Centurion University of Technology and Management as faculty and Head of the Department of Zoology has around sixteen years of teaching experience and possess specialization in Poultry management , vermicomposting processes. Her area of interest is Fishery […]