Immunology and Cancer Biology


Dr Sitaram Swain


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Course Name : Immunology and Cancer Biology

Code(Credit) : CUTM1451(3-1-0)

Course Objectives

•The primary objective of this course is to help students develop knowledge and skills related to health and disease and role of immune system.students are taught immunology so as to develop understanding of the subject, such as functioning the immune system, the molecular and cellular components and pathways that protect an organism from infectious agents.
•The common cellular and molecular mechanisms that are deregulated in cancerous cells and their contribution to the development of cancer.
•Role of gene mutation and environmental factors in the development of cancer.

Learning Outcomes

•Understand the immunomodulatory strategies essential for generating or suppressing immune responses as required in hypersensitivity reactions, transplantation, autoimmune diseases and cancer.
• Students also know about biological aspects of cancer, carcinogenesis and cancer therapy.
• Students will know the principle and application of various immune techniques and they can Will be able to make a strategy for immunological research and execute it.

Course Syllabus

Module-1 Cells and Organs of the Immune System- Hematopoiesis, Cells and Organs of the Immune System, Structure and function of antibodies, Inflammation
Practice: 1 Demonstration of lymphoid organs
Module-II Development and Signaling of Immune system- Innate Immunity, TLRs and their role in innate, immune response Adaptive Immunity, cytokines, development of B-lymphocyte and T-lymphocyte
Practice: 2 To isolate the lymphocyte from whole blood by density gradient centrifugation method
Module III Structure and function of MHC complex -antigen processing cells, antigen processing and presentation to T lymphocytes, MHC restriction. TCR structure and function
Practice:3 Screening antisera or hybridoma supernatants for specific antibodies
Module-IV Effector mechanisms and regulation of immune responses: Complement system, hypersensitivity, autoimmunity and tolerance, transplantation
Module V Techniques related to immunology Monoclonal Antibodies, Vaccines , Radio immunoassay, ELISA,Diffusion.
Practice : 4 To detect the presence of an antigen in a sample
Practice:5 To learn coupling of antibody to enzyme Horse Radish Peroxidase (HRP)
Practice: 6 Study of basic Ouchterlony’s double immuno-diffusion method.
Module-VI biology of cancer cells, Genetics of Cancer, Genetic Variation and Mutation, Two-Hit Hypothesis , Epigenetics of cancer
Practice:7 Tumor cell growth in different media
Module VII Oncogene and tumour suppressor gene: progression of cancer, Metastasis, apoptosis in cancer, DNA repair in cancer
Recommended books:
Text Books:
Owen, J. A., Punt, J., & Stranford, S. A. (2013). Kuby immunology . seventh Edition, New York: WH Freeman.
Robert A. Weinberg, “The Biology of Cancer,” Garland Science; 1 Cdr Edition, 2010
Reference Books:
1. Owen, J. A., Punt, J., & Stranford, S. A. (2013). Kuby immunology . New York: WH Freeman.
2. Abbas, K. Abul and Lechtman H. Andrew (2003.) Cellular and Molecular Immunology, V Edition, Saunders Publication.
3. Janeway's Immunobiology(2016) 9th Edition, by Kenneth Murphy, Casey Weaver, Garland Science
4. David Male, Jonathan Brostoff, David Roth and Ivan Roitt(2012) Immunology,8th Edition, Elsevier Publication
5. Lauren Pecorino, “Molecular Biology of cancer: Mechanisms, Targets, and Terapeutics,” Oxford University Press. 3rd edition, 2012.

Session Plan

Session 1

Session 22

Session 23

Session 27

Session 30

Session 34

Case Studies

Case Studies

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    Dr Sitaram Swain

    Assistant Professor

    Dr Sitaram Swain has received PhD degree from Utkal University in the year 2017. He is also trained and experienced from TATA Memorial Hospital, Mumbai, India. He has experienced with cell line culture, clinical biochemistry, immuno-fixation, immunoassay, cancer cytogenetic, serum protein electrophoresis and tumour marker analysis. He has qualified NET(ICAR-ASRB) in Animal biotechnology. He has […]