Medicinal Chemistry-I (Practical)
Teacher
Biswajit Samantaray
Category
Core Courses
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Course Name : Medicinal Chemistry-I(Practical)
Code(Credit) : BPHL2201(0-2-0)
Course Objectives
Upon completion of the course the student shall be able to
- Understand the chemistry of drugs with respect to their pharmacological activity
- Understand the drug metabolic pathways, adverse effect and therapeutic value of drugs
- Know the Structural Activity Relationship (SAR) of different class of drugs
- Write the chemical synthesis of some drugs
Course Outcomes
| CO | Statements | PO MAPPING |
| CO-1 | Understand the chemistry of drugs with respect to their pharmacological activity
|
PO1, PO2, PO3, PO11 |
| CO-2 | Understand the drug metabolic pathways, adverse effect and therapeutic value of
drugs |
PO1, PO2, PO11 |
| CO-3 | To get knowledge about Structural Activity Relationship (SAR) of different class of drugs | PO1, PO2, PO5, PO11 |
| CO-4 | Write the chemical synthesis of some drugs | PO1, PO2, PO5,PO11 |
| CO-5 | Able to summarize definition, classification, mechanism of action along with structures of drugs belongs to various category | PO1, PO2, PO11 |
List of Experiment
I Preparation of drugs/ intermediates
1 1,3-pyrazole
2 1,3-oxazole
3 Benzimidazole
4 Benztriazole
5 2,3- diphenyl quinoxaline
6 Benzocaine
7 Phenytoin
8 Phenothiazine
9 Barbiturate
II Assay of drugs
1 Chlorpromazine
2 Phenobarbitone
3 Atropine
4 Ibuprofen
5 Aspirin
6 Furosemide
III Determination of Partition coefficient for any two drugs
Reference
1) Vogels textbook of practical organic chemistry,5th edition
2) Comprehensive practical organic chemistry by V.K.Ahluwalia and Renu Aggarwal
Session Plan
Experiment 1
Preparation of drugs/ intermediates of Benzimidazole.
Case Studies
Case Studies
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