Medicinal Chemistry-I (Practical)

Teacher

Biswajit Samantaray

Category

Core Courses

Course Attendees

Still no participant

Course Reviews

Still no reviews

Course Name : Medicinal Chemistry-I(Practical)

Code(Credit) : BPHL2201(0-2-0)

Course Objectives

Upon completion of the course the student shall be able to

  1. Understand the chemistry of drugs with respect to their pharmacological activity
  2. Understand the drug metabolic pathways, adverse effect and therapeutic value of drugs
  3. Know the Structural Activity Relationship (SAR) of different class of drugs
  4. Write the chemical synthesis of some drugs

CourseĀ  Outcomes

CO Statements PO MAPPING
CO-1 Understand the chemistry of drugs with respect to their pharmacological activity

 

PO1, PO2, PO3, PO11
CO-2 Understand the drug metabolic pathways, adverse effect and therapeutic value of

drugs

PO1, PO2, PO11
CO-3 To get knowledge aboutĀ  Structural Activity Relationship (SAR) of different class of drugs PO1, PO2, PO5, PO11
CO-4 Write the chemical synthesis of some drugs PO1, PO2, PO5,PO11
CO-5 Able to summarize definition, classification, mechanism of action along with structures of drugs belongs to various category PO1, PO2, PO11

List of Experiment

I Preparation of drugs/ intermediates
1 1,3-pyrazole
2 1,3-oxazole
3 Benzimidazole
4 Benztriazole
5 2,3- diphenyl quinoxaline
6 Benzocaine
7 Phenytoin
8 Phenothiazine
9 Barbiturate
II Assay of drugs
1 Chlorpromazine
2 Phenobarbitone
3 Atropine
4 Ibuprofen
5 Aspirin
6 Furosemide
III Determination of Partition coefficient for any two drugs

Reference
1) Vogels textbook of practical organic chemistry,5th edition
2) Comprehensive practical organic chemistry by V.K.Ahluwalia and Renu Aggarwal

Session Plan

Experiment 1

Preparation of drugs/ intermediates of Benzimidazole.

1.benzimidazole

https://www.youtube.com/watch?v=KS-BhURpJt4

Experiment 2

Experiment 3

Preparation of Benzocaine

3.Benzocaine

Experiment 4

Preparation of Phenytoin

4.Phenytoin

Experiment 5

Preparation of Phenothiazine

5.Phenothiazine

Experiment 6

Preparation of Barbituric acid

6.barbuturic acid

Experiment 7

Assay of Chlorpromazine

7.Chlorpromazine

Experiment 8

Assay of Phenobarbitone

8.Phenobarbitone

Experiment 9

Assay of Atropine

9.Atropine

Experiment 10

Assay of Ibuprofen

10.Ibuprofen

Experiment 11

Assay of Furosemide

11.Furosemide

Experiment 12

Determination of Partition coefficient of drug

12.partitionn coefficient1

Experiment 13

Determination of Partition coefficient of drug

13.partition coefficient2

Case Studies

Case Studies

Our Main Teachers