MEDICINAL CHEMISTRY (PRACTICAL)-III
Teacher
Mr. Satish Kanhar
Category
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Course Name : MEDICINAL CHEMISTRY- III (Practical)
Code(Credit) : BPHL3201
Course Objectives
After successful completion of this course students will be able to:
- Explain the physical chemical properties of drugs using drug design software.
- Draw chemical structures and reactions by Chem draw software.
- Analyze the purity of medicinal compounds.
- Prepare medicinally important compounds / intermediates.
- Synthesize medicinal compounds
- Estimate partition coefficient of drugs
Course Outcomes
| CO | Statement | Mapping with POs |
| CO-1 | Understand the importance of drug design and different techniques of drug design. | PO1, PO2, PO5 |
| CO-2 | Understand the chemistry of drugs with respect to their biological activity. | PO1, PO2, PO5 |
| CO-3 | Know the metabolism, adverse effects and therapeutic value of drugs. | PO1, PO2, PO5 |
| CO-4 | To develop entrepreneurship qualities that support growth of pharmaceutical | PO1, PO2, PO5 |
| CO-5 | Implementing the knowledge to determine Structure, nomenclature, metabolism and uses of Various Antibiotics., Chemotherapeutic agents. | PO1, PO2, PO5 |
Course Syllabus
I Preparation of drugs and intermediates
1 Sulphanilamide
2 7-Hydroxy-4-methyl coumarin
3 Chlorobutanol
4 Triphenyl imidazole
5 Tolbutamide
6 Hexamine
II Assay of drugs
1 Isonicotinic acid hydrazide
2 Chloroquine
3 Metronidazole
4 Dapsone
5 Chlorpheniramine maleate
6 Benzyl penicillin
III Preparation of medicinally important compounds or intermediates by Microwave irradiation technique
IV Drawing structures and reactions using chem draw®
V Determination of physicochemical properties such as logP, clogP, MR, Molecular weight, Hydrogen bond donors and acceptors for class of drugs course content using drug design software Drug likeliness screening (Lipinskies RO5)
Session Plan
Session 1
Experiment 1: Preparation of sulfanilamide
https://labmonk.com/synthesis-of-sulphanilamide-from-acetanilide
Session 2
Experiment 2: Preparation of 7-Hydroxy-4-methyl coumarins
Session 11
Experiment 11: Assay of Chloropheniramine maleate
Session 13
Experiment 13: Preparation of medicinally important compounds or intermediates by Microwave irradiation technique
Session 14
Experiment 14: Drawing structures and reactions using chem draw®
Session 15
Experiment 15: Determination of physicochemical properties such as logP, clogP, MR, Molecular weight, Hydrogen bond donors and acceptors for class of drugs course content using drug design software Drug likeliness screening (Lipinskies RO5)
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