MOLECULAR PHARMACEUTICS (NANO TECHNOLOGY & TARGETED DDS) CUTM1589

Scope

This course is designed to impart knowledge on the area of advances in novel drug delivery systems.

Objectives

Upon completion of the course student shall be able to understand

•  The various approaches for development of novel drug delivery
  systems.
• The criteria for selection of drugs and polymers for the development of NTDS .
• The formulation and evaluation of novel drug delivery systems.

Syllabus

1. Targeted Drug Delivery Systems: Concepts, Events and
biological process involved in drug targeting. Tumor targeting and
Brain specific delivery.

2. Targeting Methods: introduction preparation and evaluation. Nano Particles & Liposomes: Types, preparation and evaluation.

3. Micro Capsules / Micro Spheres: Types, preparation and
evaluation , Monoclonal Antibodies ; preparation and application, preparation and application of Niosomes, Aquasomes, Phytosomes, Electrosomes.

4. Pulmonary Drug Delivery Systems : Aerosols, propellents, ContainersTypes, preparation and evaluation, Intra Nasal Route
Delivery systems; Types, preparation and evaluation.

5. Nucleic acid based therapeutic delivery system : Gene therapy,
introduction (ex-vivo & in-vivo gene therapy). Potential target
diseases for gene therapy (inherited disorder and cancer). Gene
expression systems (viral and nonviral gene transfer). Liposomal
gene delivery systems.

Biodistribution and Pharmacokinetics knowledge of therapeutic antisense molecules and aptamers as drugs of future

REFERENCES

1. Y W. Chien, Novel Drug Delivery Systems, 2nd edition, revised and
expanded,Marcel Dekker, Inc., New York, 1992.
2. S.P.Vyas and R.K.Khar, Controlled Drug Delivery - concepts and
advances, VallabhPrakashan, New Delhi, First edition 2002.
3. N.K. Jain, Controlled and Novel Drug Delivery, CBS Publishers &
Distributors, NewDelhi, First edition 1997 (reprint in 2001).

Session Plan

Session 1.

Targeted Drug Delivery Systems:

Session 2.

Targeting Methods:

Session 3.

Micro Capsules / Micro Spheres:

https://www.researchgate.net/publication/335421817_MicrocapsulesMicrospheres_Types_Preparation_and_Evaluation_Monoclonal_Antibodies_Preparation_and_Application_Niosomes_Aquasomes_Phytosomes_Electrosomes_Preparation_and_Application

Session 4.

Pulmonary Drug Delivery Systems

https://www.researchgate.net/publication/340818255_Pulmonary_Drug_Delivery_Systems_Aerosols_Propellents_Containers_Types_Preparation_and_Evaluation_Intranasal_Route_Delivery_Systems_Types_Preparation_And_Evaluation

Session 5.

Nucleic acid based therapeutic delivery system :https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722627/