NOVEL DRUG DELIVERY SYSTEMS (M Pharm, Industrial Pharmacy)
Teacher
Dr. Rudra Narayan Sahoo
Category
Core Courses
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Course Name : NOVEL DRUG DELIVERY SYSTEMS
Code(Credit) : CUTM2002(4-0-0)
Course Objectives
This course is designed to impart knowledge and skills necessary to train the
students in the area of novel drug delivery systems.
Learning Outcomes
On completion of this course it is expected that students will be able to
understand,
The need, concept, design and evaluation of various customized,
sustained and controlled release dosage forms.
To formulate and evaluate various novel drug delivery systems
Course Syllabus
Module-I
Concept & Models for NDDS: Classification of rate controlled drug delivery systems (DDS), rate programmed release, activation modulated & feedback regulated DDS, effect of system parameters in controlled drug delivery, computation of desired release rate and dose for controlled release DDS, pharmacokinetic design for DDS – intermittent, zero order & first order release.
Carriers for Drug Delivery: Polymers / co-polymersintroduction, classification, characterization, polymerization techniques, application in CDDS / NDDS, biodegradable & natural polymers.
Module-II
Study of Various DDS: Concepts, design, formulation & evaluation of controlled release oral DDS, Mucoadhesive DDS (buccal, nasal, pulmonary) Pulsatile, colon specific, liquid sustained release systems, Ocular delivery systems.
Module-III
Transdermal Drug Delivery Systems: Theory, design, formulation & evaluation including iontophoresis and other latest developments in skin delivery systems.
Module-IV
Sub Micron Cosmeceuticals: Biology, formulation science and evaluation of various cosmetics for skin, hair, nail, eye etc and it’s regulatory aspects.
Module-V
Targeted Drug Delivery Systems: Importance, concept, biological process and events involved in drug targeting, design, formulation & evaluation, methods in drug targeting – nanoparticles, liposomes, niosomes, pharmacosomes, resealed erythrocytes, microspheres, magnetic microspheres. Specialized pharmaceutical emulsions – multiple emulsions, micro-emulsions.
Module-VI
Protein / Peptide Drug Delivery Systems: Concepts, delivery techniques, formulation, stability testing, causes of protein destabilization, stabilization methods.
Module-VII
Biotechnology in Drug Delivery Systems: Brief review of major areas recombinant DNA technology, monoclonal antibodies, gene therapy.
Module-VIII
New trends for Personalized Medicine: Introduction, Definition, Pharmacogenetics, Categories of Patients for Personalized Medicines: Customized drug delivery systems, Bioelectronic Medicines, 3D printing of pharmaceuticals, Telepharmacy.
Reference Books
1. Novel Drug Delivery System, Y.W. Chein, Vol 50, Marcel Dekker, NY.
2. Controlled Drug Delivery Systems, Robinson, Vol 29, Marcel Dekker, NY.
3. Transdermal Controlled Systemic Medications, YW Chein, Vol 31, Marcel
Dekker, NY.
4. Bioadhesive DDS, E. Mathiowitz, Vol 98, Marcel Dekker, NY.
5. Nasal System Drug Delivery, K.S.E. Su, Vol 39, Marcel Dekker, NY.
6. Drug Delivery Devices, Vol 32, P Tyle Marcel Dekker, NY.
7. Polymers for Controlled Drug Delivery, P.J. Tarcha, CRC Press.
8. Pharmaceutical Biotechnology, Vyas, CBS, Delhi.
9. Biotechnology of Industrial Antibiotics, E.J. Vandamme, Marcel Dekker, NY.
10. Protein Formulation & Delivery, E.J. McNally, Vol 99, Marcel Dekker, NY.
11. Drug Targeting, M.H. Rubinstein, John Wiley, NY.
Session Plan
Session 1
Classification of rate controlled drug delivery systems controlled
Session 4
Effect of system parameters in controlled drug delivery
Session 5
Computation of desired release rate and dose for controlled release DDS
Session 12
Concept design formulation and evaluation of controlled release oral DDS
Session 13
Concept design formulation and evaluation of controlled release mucoadhesive DDS
Session 14
Concept design formulation and evaluation of controlled release colon specific DDS
Session 15
Concept design formulation and evaluation of controlled release buccal DDS
Session 16
Concept design formulation and evaluation of controlled release nasal DDS
Session 17
Concept design formulation and evaluation of controlled release pulmonary DDS
Session 18
Concept design formulation and evaluation of controlled release liquid sustained release systems DDS.
Session 19
Concept design formulation and evaluation of controlled release ocular DDS.
Session 21
Introduction to transdermal drug delivery system
Session 27
Biology formulation science and evaluation of various cosmetic for skin
Session 28
Biology formulation science and evaluation of various cosmetics for hair
Session 29
Biology formulation science and evaluation of various cosmetic for nail
Session 30
Biology formulation science and evaluation of various cosmetic for eye
Session 31
Biology formulation science and evaluation of various cosmetic for skin
Session 33
Importnace concept biological process and events involved in drug targeting
Session 34
Design formultion and evaluation methods in drug targeting nanoparticles liposomes niosomes pharmacosomes
Session 35
Specialized pharmaceutical emulsions
Session 36
protein peptide drug delivery systems
Session 37
Biotechnology in drug delivery system
Session 40
3D printing
Session 38
New trends for personalize medicine
Session 39
Bioelectronic medicine
Case Studies
Case Studies
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