Course objective
- To have understanding of behavior, structure and bonding of organometallic componds.
- To understand concepts bioinorganic chemistry.
Course Outcomes
| COs | Course outcomes | Mapping COs with POs (High-3, Medium-2, Low-1) |
| CO1 | Able to gain knowledge on the bonding behaviour and reactions of oranometallic compounds. | PO1(3),PO10(2),PO12(2) |
| CO3 | Investigation and Judgements of various bioinorganic activities of living bodies | PO3(3), PO5(2),PO7(2) |
| CO4 | Able to solve different problems related to structural analysis | PO3(2),PO4(3),PO13(3) |
Module I Organometallic compounds: synthesis, bonding and structure, and reactivity.Transition Metal π- Complexes Transition Metal π- Complexes with unsaturated organic molecules, alkenes, alkynes, allyl, diene, dienyl, arene and trienyl complexes, preparations, properties, nature of bonding and structural features. Important reactions relating to nucleophilic and electrophilic attack on ligands and to organic synthesis. Transition Metal Compounds with Bonds to Hydrogen Transition metal hydrides: Synthesis, properties and reactivity. Transition metal dihydrogen compound: Preparation, properties and reactivity. (4 hours)
Module II: Organometallics in homogeneous catalysis.Coordinative unsaturation, oxidative addition and reductive elimination reactions. Insertion reactions (insertion of CO, SO2 and alkenes). Reactions of coordinated CO in metal carbonyls. Homogenous hydrogenation of alkenes, hydroformylation of alkenes, isomerisation of olefins, Wacker’s process, Zeigler-Natta Polymerization of ethylene, Monsanto acetic acid, Reduction of CO by hydrogen (Fischer-Tropsch reaction). (4 hours)
Module III: Cages and metal clusters, Metal cluster compounds. Preparative methods for metal cluster compounds. Various types of reactions of metal cluster compounds, Cluster of borane and higher boranes compounds. (4 hours)
Module IV: Analytical chemistry- separation, spectroscopic, electro- and thermoanalytical methods.
Spectroscopic methods Atomic adsorption spectroscopy: Principle and instrumentation, flame atomization, hollow cathode lamps, interference in AAS, applications of AAS in qualitative and quantitative analysis.
Flame photometric methods: Basic principle and instrumentation, applications in quantitative analysis. (4 hours)
Module V:Characterisation of inorganic compounds by IR, Raman, UV-vis, NQR, MS, electron spectroscopy and microscopic techniques.
Nuclear Magnetic Resonance contact shifts, factors affecting nuclear relaxation, some applications including biochemical systems, an overview of NMR of metal nuclides EPR: Hyperfine coupling, spin polarization for atoms and transition metal ions, spin-orbit coupling and applications.
Mossbauer Spectroscopy Basic principles, spectral line shape and natural line width, characteristics of Mossbauer nucleides, Dopplers effect, Applications of Mossbauer Spectroscopy. (6 hours)
Module VI: Bioinorganic chemistry 1: photosystems,Chlorophylls, photo system I and photo system II in cleavage of water porphyrins, metalloenzymes, metalloenzymes containing magnesium, molybdenum, iron, cobalt, copper and zinc.oxygen transport, oxygen binding,Ion (Na+ and K+ ) transport, Transport and storage of dioxygen Heme proteins and oxygen uptake, structure and function of hemoglobin, myoglobin, hemocyanins and hemerthrin, model synthetic complexes of iron, cobalt and copper
(4 hours)
Module VII: Bioinorganic chemistry 2:Transport and utilization, electron- transfer reactions; nitrogen fixation, Biological nitrogen fixation, molybdenum nitrogenase, spectroscopic and other evidence, other nitrogenases model systems.metal complexes in medicine. (4 hours)
Project: Students shall have to complete a given project related to the domain topics and submit report.