PHARMACEUTICAL ENGINEERING
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PHARMACEUTICAL ENGINEERING (Theory)
Teacher
Shubhashree Das
Category
Core Courses
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Course Name : PHARMACEUTICAL ENGINEERING
Code(Credit) : BPHT2104 (4-0-0)
Course Objectives
- This course is designed to impart a fundamental knowledge on the art and science of various unit operations used in pharmaceutical industry.
Course Outcomes:
| CO | Statements |
| CO-1 | To know various unit operations used in Pharmaceutical industries |
| CO-2 | To understand the material handling techniques |
| CO-3 | To get knowledge to perform various processes involved in pharmaceutical manufacturing process |
| CO-4 | To carry out various test to prevent environmental pollution |
| CO-5 | To appreciate and comprehend significance of plant lay out design for optimum use of resources |
COs & POs Mapping
| CO | Statements | POs Mapping |
| CO-1 | To know various unit operations used in Pharmaceutical industries | PO1, PO2, PO3, PO6, PO10, PO11 |
| CO-2 | To understand the material handling techniques | PO1, PO6, PO7, PO11 |
| CO-3 | To get knowledge to perform various processes involved in pharmaceutical manufacturing process | PO1, PO2, PO3, PO6, PO10, PO11 |
| CO-4 | To carry out various test to prevent environmental pollution | PO1, PO7, PO10, PO11 |
| CO-5 | To appreciate and comprehend significance of plant lay out design for optimum use of resources | PO1, PO3, PO7, PO10, PO11 |
Course Syllabus
MODULE- I
• Flow of fluids: Types of manometers, Reynolds number and its significance,
Bernoulli’s theorem and its applications, Energy losses, Orifice meter, Venturimeter, Pitot tube and Rotometer.
• Size Reduction: Objectives, Mechanisms & Laws governing size reduction, factors affecting size reduction, principles, construction, working, uses, merits and demerits of Hammer mill, ball mill, fluid energy mill, Edge runner mill & end runner mill.
• Size Separation: Objectives, applications & mechanism of size separation, official standards of powders, sieves, size separation Principles, construction, working, uses, merits and demerits of Sieve shaker, cyclone separator, Air separator, Bag filter & elutriation tank.
MODULE- II
• Heat Transfer: Objectives, applications & Heat transfer mechanisms. Fourier’s law, Heat transfer by conduction, convection & radiation. Heat interchangers & heat exchangers.
• Evaporation: Objectives, applications and factors influencing evaporation,
differences between evaporation and other heat process. principles, construction, working, uses, merits and demerits of Steam jacketed kettle, horizontal tube evaporator, climbing film evaporator, forced circulation evaporator, multiple effect evaporator& Economy of multiple effect evaporator.
• Distillation: Basic Principles and methodology of simple distillation,flash
distillation, fractional distillation, distillation under reduced pressure, steam
distillation & molecular distillation.
MODULE- III
• Drying: Objectives, applications & mechanism of drying process, measurements & applications of Equilibrium Moisture content, rate of drying curve. principles, construction, working, uses, merits and demerits of Tray dryer, drum dryer spray dryer, fluidized bed dryer, vacuum dryer, freeze dryer.
• Mixing: Objectives, applications & factors affecting mixing, Difference between solid and liquid mixing, mechanism of solid mixing, liquids mixing and semisolids mixing. Principles, Construction, Working, uses, Merits and Demerits of Double cone blender, twin shell blender, ribbon blender, Sigma blade mixer, planetarymixers, Propellers, Turbines, Paddles & Silverson Emulsifier.
MODULE- IV
• Filtration: Objectives, applications, Theories & Factors influencing filtration, filter aids, filter medias. Principle, Construction, Working, Uses, Merits and demerits of plate & frame filter, filter leaf, rotary drum filter, Meta filter & Cartridge filter, membrane filters and Seidtz filter.
• Centrifugation: Objectives, principle & applications of Centrifugation, principles, construction, working, uses, merits and demerits of Perforated basket centrifuge, Nonperforated basket centrifuge, semi continuous centrifuge & super centrifuge.
MODULE- V
• Materials of pharmaceutical plant construction, Corrosion and its prevention:
Factors affecting during materials selected for Pharmaceutical plant construction, Theories of corrosion, types of corrosion and there prevention. Ferrous and nonferrous
Recommended Books
1. Introduction to chemical engineering – Walter L Badger & Julius Banchero, Latest
edition.
2. Solid phase extraction, Principles, techniques and applications by Nigel J.K.
Simpson- Latest edition.
3. Unit operation of chemical engineering – Mcabe Smith, Latest edition.
4. Pharmaceutical engineering principles and practices – C.V.S Subrahmanyam et al.,
5. Remington practice of pharmacy- Martin, Latest edition.
6. Theory and practice of industrial pharmacy by Lachmann., Latest edition.
7. Physical pharmaceutics- C.V.S Subrahmanyam et al., Latest edition.
8. Cooper and Gunn’s Tutorial pharmacy, S.J. Carter, Latest edition.
Session Plan
Session 1
Flow of fluids: Types of manometers, Reynolds number and its significance
Session 2
Bernoulli’s theorem and its applications
Session 3
Session 4
Size Reduction: Objectives, Mechanisms & Laws governing size reduction, factors affecting size reduction
Session 5
Principles, construction, working, uses, merits and demerits of Hammer mill,
Session 6
Ball mill
Session 7
Fluid Energy Mill, Edge Runner Mill, End Runner Mill
Study of Fluid Energy Mill, Edge runner mill and end runner mill
Session 8
Size Separation: Objectives, applications & mechanism of size separation, official
standards of powders
Size separation by sifting and official standard for powders
Session 9
Sieves, principles, construction, working, uses, merits and demerits of Sieve shaker
Size separation by sifting and official standard for powders
Session 10
Cyclone separator, Air separator and Bag Filter
Construction and working of cyclone separator,air separtor and bag filter
Session 11
Elutriation tank
Session 12
Heat Transfer: Objectives, applications & Heat transfer mechanisms
Session 13
Fourier’s law, Heat transfer by conduction, convection & radiation.
Session 14
Heat interchangers & heat exchangers.
Session 15
Evaporation: Objectives, applications and factors influencing evaporation, differences between evaporation and other heat process.
Session 16
Principles, construction, working, uses, merits and demerits of Steam jacketed kettle, horizontal tube evaporator
Session 17
Climbing film evaporator, forced circulation evaporator, multiple effect evaporator
Session 18
Distillation: Basic Principles and methodology of simple distillation
Session 19
Flash distillation, Fractional distillation and Distillation under reduced pressure
Session 20
Steam distillation and Molecular distillation
Session 21
Drying: Objectives, applications & mechanism of drying process,
Session 22
Measurements & applications of Equilibrium Moisture content, Rate of drying curve
Measurements & applications of Equilibrium Moisture content, rate of drying curve
Session 23
Principles, construction, working, uses, merits and demerits of Tray dryer, drum dryer
Session 24
Spray dryer and Fluidized Bed Dryer
Session 25
Vacuum dryer & freeze dryer
Session 26
Mixing: Objectives, applications & factors affecting mixing, Difference between
solid and liquid mixing
Objectives, applications & factors affecting mixing, Difference between solid and liquid mixing
Session 27
Mechanism of solid mixing, liquids mixing and semisolids mixing
Mechanism of solid mixing, liquids mixing and semisolids mixing
Session 28
Principles, Construction, Working, uses, Merits and Demerits of Double cone
blender, twin shell blender, ribbon blender
Session 29
Sigma blade mixer, planetary mixers
Session 30
Propellers, Turbines, Paddles & Silverson Emulsifier
Session 31
Filtration: Objectives, applications, Theories & Factors influencing filtration
Session 32
Filter aids, Filter medias.
Session 33
Principle, Construction, Working, Uses, Merits and demerits of plate & frame filter, filter leaf
Session 34
Rotary drum filter, Meta filter & Cartridge filter
Session 35
Membrane filters and Seidtz filter
Session 36
Centrifugation: Objectives, principle & applications of Centrifugation, Perforated basket centrifuge
Objectives, principle & applications of Centrifugation & Perforated basket centrifuge
Session 37
Principles, construction, working, uses, merits and demerits of Non-perforated basket centrifuge, semi continuous centrifuge & super centrifuge
Non-perforated basket centrifuge, semi continuous centrifuge & super centrifuge
Session 38
Factors affecting during materials selected for Pharmaceutical plant construction
Factors affecting during materials selected for Pharmaceutical plant
Session 39
Theories of corrosion, types of corrosion and there prevention
Session 40
Ferrous and nonferrous metals, inorganic and organic non metals, basic of material handling systems.
Ferrous and nonferrous metals, inorganic and organic non metals
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