PHARMACEUTICAL ENGINEERING

per person /

Free

Home Courses

PHARMACEUTICAL ENGINEERING (Theory)

PHARMACEUTICAL ENGINEERING (Theory)

Teacher

Shubhashree Das

Category

Core Courses

Course Attendees

Still no participant

Course Reviews

Still no reviews

Course Name : PHARMACEUTICAL ENGINEERING

Code(Credit) : BPHT2104 (4-0-0)

Course Objectives

  • This course is designed to impart a fundamental knowledge on the art and science of various unit operations used in pharmaceutical industry.

Course Outcomes:

CO Statements
CO-1 To know various unit operations used in Pharmaceutical industries
CO-2 To understand the material handling techniques
CO-3 To get knowledge to perform various processes involved in pharmaceutical manufacturing process
CO-4 To carry out various test to prevent environmental pollution
CO-5 To appreciate and comprehend significance of plant lay out design for optimum use of resources

COs & POs Mapping

CO Statements POs Mapping
CO-1 To know various unit operations used in Pharmaceutical industries PO1, PO2, PO3, PO6, PO10, PO11
CO-2 To understand the material handling techniques PO1, PO6, PO7, PO11
CO-3 To get knowledge to perform various processes involved in pharmaceutical manufacturing process PO1, PO2, PO3, PO6, PO10, PO11
CO-4 To carry out various test to prevent environmental pollution PO1, PO7, PO10, PO11
CO-5 To appreciate and comprehend significance of plant lay out design for optimum use of resources PO1, PO3, PO7, PO10, PO11

Course Syllabus

MODULE- I

• Flow of fluids: Types of manometers, Reynolds number and its significance,
Bernoulli’s theorem and its applications, Energy losses, Orifice meter, Venturimeter, Pitot tube and Rotometer.
• Size Reduction: Objectives, Mechanisms & Laws governing size reduction, factors affecting size reduction, principles, construction, working, uses, merits and demerits of Hammer mill, ball mill, fluid energy mill, Edge runner mill & end runner mill.
• Size Separation: Objectives, applications & mechanism of size separation, official standards of powders, sieves, size separation Principles, construction, working, uses, merits and demerits of Sieve shaker, cyclone separator, Air separator, Bag filter & elutriation tank.

MODULE- II

• Heat Transfer: Objectives, applications & Heat transfer mechanisms. Fourier’s law, Heat transfer by conduction, convection & radiation. Heat interchangers & heat exchangers.
• Evaporation: Objectives, applications and factors influencing evaporation,
differences between evaporation and other heat process. principles, construction, working, uses, merits and demerits of Steam jacketed kettle, horizontal tube evaporator, climbing film evaporator, forced circulation evaporator, multiple effect evaporator& Economy of multiple effect evaporator.
Distillation: Basic Principles and methodology of simple distillation,flash
distillation, fractional distillation, distillation under reduced pressure, steam
distillation & molecular distillation.

MODULE- III

• Drying: Objectives, applications & mechanism of drying process, measurements & applications of Equilibrium Moisture content, rate of drying curve. principles, construction, working, uses, merits and demerits of Tray dryer, drum dryer spray dryer, fluidized bed dryer, vacuum dryer, freeze dryer.
• Mixing: Objectives, applications & factors affecting mixing, Difference between solid and liquid mixing, mechanism of solid mixing, liquids mixing and semisolids mixing. Principles, Construction, Working, uses, Merits and Demerits of Double cone blender, twin shell blender, ribbon blender, Sigma blade mixer, planetarymixers, Propellers, Turbines, Paddles & Silverson Emulsifier.

MODULE- IV

• Filtration: Objectives, applications, Theories & Factors influencing filtration, filter aids, filter medias. Principle, Construction, Working, Uses, Merits and demerits of plate & frame filter, filter leaf, rotary drum filter, Meta filter & Cartridge filter, membrane filters and Seidtz filter.
• Centrifugation: Objectives, principle & applications of Centrifugation, principles, construction, working, uses, merits and demerits of Perforated basket centrifuge, Nonperforated basket centrifuge, semi continuous centrifuge & super centrifuge.

MODULE- V

• Materials of pharmaceutical plant construction, Corrosion and its prevention:
Factors affecting during materials selected for Pharmaceutical plant construction, Theories of corrosion, types of corrosion and there prevention. Ferrous and nonferrous

Recommended Books
1. Introduction to chemical engineering – Walter L Badger & Julius Banchero, Latest
edition.
2. Solid phase extraction, Principles, techniques and applications by Nigel J.K.
Simpson- Latest edition.
3. Unit operation of chemical engineering – Mcabe Smith, Latest edition.
4. Pharmaceutical engineering principles and practices – C.V.S Subrahmanyam et al.,
5. Remington practice of pharmacy- Martin, Latest edition.
6. Theory and practice of industrial pharmacy by Lachmann., Latest edition.
7. Physical pharmaceutics- C.V.S Subrahmanyam et al., Latest edition.
8. Cooper and Gunn’s Tutorial pharmacy, S.J. Carter, Latest edition.

Session Plan

Session 1

Flow of fluids: Types of manometers, Reynolds number and its significance

Fluid flow

Session 2

Bernoulli’s theorem and its applications

Bernoullis Experiment

Session 3

Orifice meter, Venturimeter, Pitot tube and Rotometer.

Orifice meter experiment

Venturi meter

Session 4

Size Reduction: Objectives, Mechanisms & Laws governing size reduction, factors affecting size reduction

Size reduction objective and its factors

Session 5

Principles, construction, working, uses, merits and demerits of Hammer mill,

Study of hammer mill and ball mill

Session 7

Fluid Energy Mill, Edge Runner Mill, End Runner Mill

Study of Fluid Energy Mill, Edge runner mill and end runner mill

Session 8

Size Separation: Objectives, applications & mechanism of size separation, official
standards of powders

Size separation by sifting and official standard for powders

Session 9

Sieves, principles, construction, working, uses, merits and demerits of Sieve shaker

Size separation by sifting and official standard for powders

Session 10

Cyclone separator, Air separator and Bag Filter

Construction and working of cyclone separator,air separtor and bag filter

Session 11

Elutriation tank

Elutrition method

Session 12

Heat Transfer: Objectives, applications & Heat transfer mechanisms

Session 13

Fourier’s law, Heat transfer by conduction, convection & radiation.

Session 14

Heat interchangers & heat exchangers.

Heat exchanager

Session 15

Evaporation: Objectives, applications and factors influencing evaporation, differences between evaporation and other heat process.

Evaporation and factors affecting evaporation

Session 16

Principles, construction, working, uses, merits and demerits of Steam jacketed kettle, horizontal tube evaporator

Evaporators

Session 17

Climbing film evaporator, forced circulation evaporator, multiple effect evaporator

Evaporators

Session 18

Distillation: Basic Principles and methodology of simple distillation

Basic Principles and methodology of simple distillation

Session 19

Flash distillation, Fractional distillation and Distillation under reduced pressure

Flash, Fractional and Vaccum distillation

Session 20

Steam distillation and Molecular distillation

Steam distillation and Molecular distillation

Session 21

Drying: Objectives, applications & mechanism of drying process,

Introduction to Drying

Session 22

Measurements & applications of Equilibrium Moisture content, Rate of drying curve

Measurements & applications of Equilibrium Moisture content, rate of drying curve

Session 23

Principles, construction, working, uses, merits and demerits of Tray dryer, drum dryer

Tray Dryer & Drum Dryer

Session 24

Spray dryer and Fluidized Bed Dryer

Spray Dryer & Fluidized Bed Dryer

Session 25

Vacuum dryer & freeze dryer

Vacuum dryer & Freeze dryer

Session 26

Mixing: Objectives, applications & factors affecting mixing, Difference between
solid and liquid mixing

Objectives, applications & factors affecting mixing, Difference between solid and liquid mixing

Session 27

Mechanism of solid mixing, liquids mixing and semisolids mixing

Mechanism of solid mixing, liquids mixing and semisolids mixing

Session 28

Principles, Construction, Working, uses, Merits and Demerits of Double cone
blender, twin shell blender, ribbon blender

Double cone blender, twin shell blender, ribbon blender

Session 29

Sigma blade mixer, planetary mixers

Sigma blade mixer, Planetary mixer

Session 30

Propellers, Turbines, Paddles & Silverson Emulsifier

Propellers, Turbines, Paddles & Silverson Emulsifier

Session 31

Filtration: Objectives, applications, Theories & Factors influencing filtration

Introduction to filtration and it's theory

Session 32

Filter aids, Filter medias.

Filter media and filter aids

Session 33

Principle, Construction, Working, Uses, Merits and demerits of plate & frame filter, filter leaf

filtration-Instruments

Session 34

Rotary drum filter, Meta filter & Cartridge filter

filtration-Instruments

Session 35

Membrane filters and Seidtz filter

membrane filters and Seidtz filter.

Session 36

Centrifugation: Objectives, principle & applications of Centrifugation, Perforated basket centrifuge

Objectives, principle & applications of Centrifugation & Perforated basket centrifuge

Session 37

Principles, construction, working, uses, merits and demerits of Non-perforated basket centrifuge, semi continuous centrifuge & super centrifuge

Non-perforated basket centrifuge, semi continuous centrifuge & super centrifuge

Session 38

Factors affecting during materials selected for Pharmaceutical plant construction

Factors affecting during materials selected for Pharmaceutical plant

Session 39

Theories of corrosion, types of corrosion and there prevention

Session 40

Ferrous and nonferrous metals, inorganic and organic non metals, basic of material handling systems.

Ferrous and nonferrous metals, inorganic and organic non metals

Our Main Teachers

Shubhashree Das

Assistant Professor
VIEW PROFILE