Course Name: Pharmaceutical organic chemistry - I
Pharmaceutical Organic Chemistry-I (Theory)
Teacher
Biswajit Samantaray
Category
Core Courses
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Code (credit): BPHT1202 (4-0-0)
Course Objectives
This subject deals with classification and nomenclature of simple organic compounds, structural isomerism, intermediates forming in reactions, important physical properties, reactions and methods of preparation of these compounds. The syllabus also emphasizes on mechanisms and orientation of reactions.
Course Outcomes
| CO | Statements | PO MAPPING |
| CO-1 | Able to acquire knowledge about pharmaceutical organic compounds, with emphasis on their synthetic process, physical and chemical properties and compare them with each other | PO1, PO2, PO11 |
| CO-2 | Able to write mechanisms involved in various reactions that could help the students to understand the synthesis of higher organic compounds. | PO1, PO2, PO5, PO11 |
| CO-3 | Account for reactivity/stability of compounds, | PO1, PO2, PO11 |
| CO-4 | Identify/confirm the identification of organic compound | PO1, PO2, PO11 |
| CO-5 | Able to analyze various reactions for the synthesis of higher organic compounds. | PO1, PO2, PO5, PO1 |
Course Syllabus
MODULE-I
Classification, nomenclature and isomerism
Classification of Organic Compounds
Common and IUPAC systems of nomenclature of organic compounds (up to 10 Carbons open chain and carbocyclic compounds)
Structural isomerisms in organic compounds
MODULE-II
Alkanes*, Alkenes* and Conjugated dienes*
SP3 hybridization in alkanes, Halogenation of alkanes, uses of paraffins. Stabilities of alkenes, SP2 hybridization in alkenes
E1 and E2 reactions – kinetics, order of reactivity of alkyl halides, rearrangement of carbocations, Saytzeffs orientation and evidences. E1 verses E2 reactions, Factors affecting E1 and E2 reactions. Ozonolysis, electrophilic addition reactions of alkenes, Markownikoff’s orientation, free radical addition reactions of alkenes, Anti Markownikoff’s orientation.
Stability of conjugated dienes, Diel-Alder, electrophilic addition, free radical addition reactions of conjugated dienes, allylic rearrangement
MODULE-III
Alkyl halides*
SN1 and SN2 reactions - kinetics, order of reactivity of alkyl halides, stereochemistry and rearrangement of carbocations. SN1 versus SN2 reactions, Factors affecting SN1 and SN2 reactions
Structure and uses of ethylchloride, Chloroform, trichloroethylene, tetrachloroethylene, dichloromethane, tetrachloromethane and iodoform.
Alcohols*- Qualitative tests, Structure and uses of Ethyl alcohol, Methyl alcohol, chlorobutanol, Cetosteryl alcohol, Benzyl alcohol, Glycerol, Propylene glycol
MODULE-IV
Carbonyl compounds* (Aldehydes and ketones)
Nucleophilic addition, Electromeric effect, aldol condensation, Crossed Aldol condensation, Cannizzaro reaction, Crossed Cannizzaro reaction, Benzoin condensation, Perkin condensation, qualitative tests, Structure and uses of Formaldehyde, Paraldehyde, Acetone, Chloral hydrate, Hexamine, Benzaldehyde, Vanilin, Cinnamaldehyde.
MODULE-V
Carboxylic acids*
Acidity of carboxylic acids, effect of substituents on acidity, inductive effect and qualitative tests for carboxylic acids ,amide and ester
Structure and Uses of Acetic acid, Lactic acid, Tartaric acid, Citric acid, Succinic acid. Oxalic acid, Salicylic acid, Benzoic acid, Benzyl benzoate, Dimethyl phthalate, Methyl salicylate and Acetyl salicylic acid
Aliphatic amines* - Basicity, effect of substituent on Basicity. Qualitative test, Structure and uses of Ethanolamine, Ethylenediamine, Amphetamin
Reference :
1. A Text book of Organic chemistry by Arun Bahl and B.S.Bahl
2. A Text book of Organic chemistry by Rakesh kumar Parashar
3.A Text book of Organic chemistry by Dr.O.P. Tandan
SESSION 1
Classification of Organic Compounds
SESSION 2
Common and IUPAC systems of nomenclature of organic compounds
SESSION 3
Common and IUPAC systems of nomenclature of organic compounds
SESSION 4
Common and IUPAC systems of nomenclature of organic compounds
SESSION 5
Common and IUPAC systems of nomenclature of organic compounds
SESSION 6
Common and IUPAC systems of nomenclature of organic compounds
SESSION 7
Alkanes, Alkenes and Conjugated dienes
SESSION 8
SP3 hybridization in alkanes, Halogenation of alkanes, uses of paraffins. Stabilities of alkenes, SP2 hybridization in alkenes
SESSION 9
SP3 hybridization in alkanes, Halogenation of alkanes, uses of paraffins. Stabilities of alkenes, SP2 hybridization in alkenes
SESSION 10
E1 and E2 reactions – kinetics, order of reactivity of alkyl halides.
SESSION 11
rearrangement of carbocations, Saytzeffs orientation and evidences. E1 verses E2 reactions, Factors affecting E1 and E2 reactions.
SESSION 12
rearrangement of carbocations, Saytzeffs orientation and evidences. E1 verses E2 reactions, Factors affecting E1 and E2 reactions.
SESSION 13
SESSION 14
Markownikoff’s orientation, free radical addition reactions of alkenes, Anti Markownikoff’s orientation.
SESSION 15
Markownikoff’s orientation, free radical addition reactions of alkenes, Anti Markownikoff’s orientation.
SESSION 16
Stability of conjugated dienes, Diel-Alder, electrophilic addition.
SESSION 17
free radical addition reactions of conjugated dienes, allylic rearrangement
SESSION 18
free radical addition reactions of conjugated dienes, allylic rearrangement
SESSION 19
Introduction to Alkyl halides.
SESSION 20
SN1 and SN2 reactions - kinetics, order of reactivity of alkyl halides.
SESSION 21
SN1 and SN2 reactions - kinetics, order of reactivity of alkyl halides.
SESSION 22
stereochemistry and rearrangement of carbocations
SESSION 23
SN1 versus SN2 reactions
SESSION 24
Factors affecting SN1 and SN2 reactions.
SESSION 25
Structure and uses of ethylchloride, Chloroform
SESSION 26
Trichloroethylene,Tetrachloroethylene
SESSION 27
Dihalogen derivatives
SESSION 28
structure and uses of iodoform
SESSION 29
Concept of Alcohols
SESSION 30
Qualitative tests, Structure and uses of Ethyl alcohol, Methyl alcohol
SESSION 31
Qualitative tests, Structure and uses of chlorobutanol, Cetosteryl alcohol, Benzyl alcohol.
SESSION 32
Qualitative tests, Structure and uses of Glycerol, Propylene glycol.
SESSION 33
Carbonyl compounds (Aldehydes and ketones)
SESSION 34
Nucleophilic addition, Electromeric effect.
SESSION 35
aldol condensation, Crossed Aldol condensation.
SESSION 36
Benzoin condensation, Perkin condensation
SESSION 37
qualitative tests, Structure and uses of Formaldehyde, Paraldehyde, Acetone, Chloral hydrate, Hexamine, Benzaldehyde, Vanilin, Cinnamaldehyde.
SESSION 38
Acidity of carboxylic acids, effect of substituents on acidity
SESSION 39
inductive effect and qualitative tests for carboxylic acids ,amide and ester
SESSION 40
inductive effect and qualitative tests for carboxylic acids ,amide and ester
SESSION 41
SESSION 42
SESSION 43
Basicity, effect of substituent on Basicity.
SESSION 44
Qualitative test, Structure and uses of Ethanolamine, Ethylenediamine, Amphetamine.
SESSION 45
Qualitative test, Structure and uses of Ethanolamine, Ethylenediamine, Amphetamine.
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