Course Name : Pharmaceutics-I (Theory)
Pharmaceutics- I (Theory)
Teacher
Binapani Barik
Category
Core Courses
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Code(Credit) : BPHT1103(4-0-0)
Course Objectives
This course is designed to impart a fundamental knowledge on the preparatory pharmacy with arts and science of preparing the different conventional dosage forms.
COURSE OUTCOMES: On completion of this course, the successful students should be able to:
| CO | DESCRIPTION | |
| CO-1 | Know the history of profession of pharmacy | |
| CO-2 | Understand the basics of different dosage forms, pharmaceutical incompatibilities and pharmaceutical calculations | |
| CO-3 | Basic skill of handling of prescription | |
| CO-4 | Preparation of various conventional dosage forms | |
| CO-5 | Develop entrepreneurship skills that support the growth of Pharmaceutical Industry |
COs & POs Mapping
| COs | DESCRIPTION | POs MAPPING |
| CO-1 | Know the history of profession of pharmacy | PO1, PO8, PO11 |
| CO-2 |
Understand the basics of different dosage forms, pharmaceutical incompatibilities and pharmaceutical calculations |
PO1, PO2,PO3,PO6, PO11 |
| CO-3 | Basic skill of handling of prescription | PO1, PO2,PO6,PO7,PO8,PO9 PO11 |
| CO-4 |
Preparation of various conventional dosage forms |
PO1, PO2,PO4,PO6 PO11 |
| CO-5 |
Develop entrepreneurship skills that support the growth of Pharmaceutical Industry |
PO1, PO4,PO10,PO11 |
Course Syllabus
MODULE – I
- Historical background and development of profession of pharmacy: History of profession of Pharmacy in India in relation to pharmacy education, industry and organization, Pharmacy as a career, Pharmacopoeias: Introduction to IP, BP, USP and Extra Pharmacopoeia.
- Dosage forms: Introduction to dosage forms, classification and definitions
- Prescription: Definition, Parts of prescription, handling of Prescription and Errors in prescription.
- Posology: Definition, Factors affecting posology. Pediatric dose calculations based on age, body weight and body surface area.
MODULE – II
- Pharmaceutical calculations: Weights and measures – Imperial & Metric system, Calculations involving percentage solutions, alligation, proof spirit and isotonic solutions based on freezing point and molecular weight.
- Powders: Definition, classification, advantages and disadvantages,Simple & compound powders – official preparations, dusting powders, effervescent, efflorescent and hygroscopic powders, eutectic mixtures. Geometric dilutions.
- Liquid dosage forms: Advantages and disadvantages of liquid dosage forms. Excipients used in formulation of liquid dosage forms. Solubility enhancement techniques.
MODULE – III
- Monophasic liquids: Definitions and preparations of Gargles, Mouthwashes, Throat Paint, Eardrops, Nasal drops, Enemas, Syrups, Elixirs, Liniments and Lotions.
- Biphasic liquids:
- Suspensions: Definition, advantages and disadvantages, classifications, Preparation of suspensions; Flocculated and Deflocculated suspension & stability problems and methods to overcome.
- Emulsions: Definition, classification, emulsifying agent, test for the identification of type of Emulsion, Methods of preparation & stability problems and methods to overcome.
MODULE – IV
- Suppositories: Definition, types, advantages and disadvantages, types of bases, methods of preparations. Displacement value & its calculations, evaluation of suppositories.
- Pharmaceutical incompatibilities: Definition, classification, physical, chemical and therapeutic incompatibilities with examples.
MODULE – V
- Semisolid dosage forms: Definitions, classification, mechanisms and factors influencing dermal penetration of drugs. Preparation of ointments, pastes, creams and gels. Excipients used in semi solid dosage forms. Evaluation of semi solid dosages forms.
Recommended Books:
- H.C. Ansel et al., Pharmaceutical Dosage Form and Drug Delivery System, Lippincott Williams andWalkins, New Delhi.
- Carter S.J., Cooper and Gunn’s-Dispensing for Pharmaceutical Students, CBS publishers, New Delhi.
- M.E. Aulton, Pharmaceutics, The Science& Dosage Form Design, Churchill Livingstone, Edinburgh.
- Indian pharmacopoeia.
- British pharmacopoeia.
- Lachmann. Theory and Practice of Industrial Pharmacy,Lea& Febiger Publisher, The University of Michigan.
- Alfonso R. Gennaro Remington. The Science and Practice of Pharmacy, Lippincott Williams, New Delhi.
- Carter S.J., Cooper and Gunn’s. Tutorial Pharmacy, CBS Publications, New Delhi.
- E.A. Rawlins, Bentley’s Text Book of Pharmaceutics, English Language Book Society, Elsevier Health Sciences, USA.
- Isaac Ghebre Sellassie: Pharmaceutical Pelletization Technology, Marcel Dekker, INC, New York.
- Dilip M. Parikh: Handbook of Pharmaceutical Granulation Technology, Marcel Dekker, INC, New York.
- Francoise Nieloud and Gilberte Marti-Mestres: Pharmaceutical Emulsions and Suspensions, Marcel Dekker, INC, New York.
Session Plan
Session 1
History of profession of Pharmacy in India in relation to pharmacy education, industry and organization, Pharmacy as a career.
Historical background and development of profession of pharmacy
Session 2
Pharmacopoeias: Introduction to IP, BP, USP and Extra Pharmacopoeia.
Historical background and development of profession of pharmacy
Session 3
Session 4
Prescription: Definition, Parts of prescription, handling of Prescription and Errors in prescription.
Session 7
Pharmaceutical calculations: Weights and measures – Imperial & Metric System.
Session 8
Pharmaceutical calculations: Calculations involving percentage solutions, allegation.
Session 9
Pharmaceutical calculations: proof spirit and isotonic solutions based on freezing point and molecular weight.
Session 10
Powders: Definition, classification, advantages and disadvantages, Simple & compound powders.
Session 14
Introduction to liquid dosage forms. Advantages and disadvantages of liquid dosage forms.
Session 15
Introduction to monophasic dosages form. Definitions and preparations of Gargles, Mouthwashes, Throat Paint.
Session 17
Definitions and preparations of Syrups, Elixirs, Liniments, and Lotions.
Session 18
Introduction to biphasic liquid dosages form.
Session 19
Suspensions: Definition, advantages, and disadvantages, classifications.
Session 20
Preparation of suspensions; Flocculated and Deflocculated suspension.
Session 21
Suspensions: stability problems and methods to overcome.
Session 22
Emulsions: Definition, classification, emulsifying agent.
Session 23
Methods of preparation of Emulsion, test for the identification.
Session 24
Methods of preparation of Emulsion, test for the identification.
Session 25
Emulsions stability problems and methods to overcome.
Session 26
Suppositories: Definition, Types, advantages, and disadvantages.
Session 27
Types of bases, methods of preparations of suppositories.
Session 28
Pharmaceutical incompatibilities: Definition, classification.physical, chemical, and therapeutic incompatibilities with examples.
Session 29
Semisolid dosage forms: Definitions, classification.
Mechanisms and factors influencing dermal penetration of drugs.
Preparation of ointments, pastes, creams, and gels.
Session 30
Excipients used in semi-solid dosage forms.
Evaluation of semi-solid dosages forms.
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