Pharmaceutics- I (Theory)

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Binapani Barik

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Course Name : Pharmaceutics-I (Theory)

 

 

Code(Credit) : BPHT1103(4-0-0)

Course Objectives

This course is designed to impart a fundamental knowledge on the preparatory pharmacy with arts and science of preparing the different conventional dosage forms.

COURSE OUTCOMES: On completion of this course, the successful students should be able to:

CO                                                   DESCRIPTION
CO-1 Know the history of profession of pharmacy
CO-2 Understand the basics of different dosage forms, pharmaceutical incompatibilities and pharmaceutical calculations
CO-3 Basic skill of handling of prescription
CO-4 Preparation of various conventional dosage forms
CO-5 Develop entrepreneurship skills that support the growth of Pharmaceutical Industry

 

COs & POs Mapping

COs                                                   DESCRIPTION POs MAPPING
CO-1 Know the history of profession of pharmacy PO1, PO8, PO11
CO-2  

Understand the basics of different dosage forms, pharmaceutical incompatibilities and pharmaceutical calculations

PO1, PO2,PO3,PO6, PO11
CO-3 Basic skill of handling of prescription PO1, PO2,PO6,PO7,PO8,PO9 PO11
CO-4  

Preparation of various conventional dosage forms

PO1, PO2,PO4,PO6 PO11
CO-5  

Develop entrepreneurship skills that support the growth of Pharmaceutical Industry

PO1, PO4,PO10,PO11

Course Syllabus

MODULE – I

  • Historical background and development of profession of pharmacy: History of profession of Pharmacy in India in relation to pharmacy education, industry and organization, Pharmacy as a career, Pharmacopoeias: Introduction to IP, BP, USP and Extra Pharmacopoeia.
  • Dosage forms: Introduction to dosage forms, classification and definitions
  • Prescription: Definition, Parts of prescription, handling of Prescription and Errors in prescription.
  • Posology: Definition, Factors affecting posology. Pediatric dose calculations based on age, body weight and body surface area.

 

MODULE – II

  • Pharmaceutical calculations: Weights and measures – Imperial & Metric system, Calculations involving percentage solutions, alligation, proof spirit and isotonic solutions based on freezing point and molecular weight.
  • Powders: Definition, classification, advantages and disadvantages,Simple & compound powders – official preparations, dusting powders, effervescent, efflorescent and hygroscopic powders, eutectic mixtures. Geometric dilutions.
  • Liquid dosage forms: Advantages and disadvantages of liquid dosage forms. Excipients used in formulation of liquid dosage forms. Solubility enhancement techniques.

 

MODULE – III

  • Monophasic liquids: Definitions and preparations of Gargles, Mouthwashes, Throat Paint, Eardrops, Nasal drops, Enemas, Syrups, Elixirs, Liniments and Lotions.
  • Biphasic liquids:
  • Suspensions: Definition, advantages and disadvantages, classifications, Preparation of suspensions; Flocculated and Deflocculated suspension & stability problems and methods to overcome.
  • Emulsions: Definition, classification, emulsifying agent, test for the identification of type of Emulsion, Methods of preparation & stability problems and methods to overcome.

 

MODULE – IV

  • Suppositories: Definition, types, advantages and disadvantages, types of bases, methods of preparations. Displacement value & its calculations, evaluation of suppositories.
  • Pharmaceutical incompatibilities: Definition, classification, physical, chemical and therapeutic incompatibilities with examples.

 

MODULE – V

  • Semisolid dosage forms: Definitions, classification, mechanisms and factors influencing dermal penetration of drugs. Preparation of ointments, pastes, creams and gels. Excipients used in semi solid dosage forms. Evaluation of semi solid dosages forms.

 

Recommended Books:

  1. H.C. Ansel et al., Pharmaceutical Dosage Form and Drug Delivery System, Lippincott Williams andWalkins, New Delhi.
  1. Carter S.J., Cooper and Gunn’s-Dispensing for Pharmaceutical Students, CBS publishers, New Delhi.
  1. M.E. Aulton, Pharmaceutics, The Science& Dosage Form Design, Churchill Livingstone, Edinburgh.
  1. Indian pharmacopoeia.
  2. British pharmacopoeia.
  3. Lachmann. Theory and Practice of Industrial Pharmacy,Lea& Febiger Publisher, The University of Michigan.
  1. Alfonso R. Gennaro Remington. The Science and Practice of Pharmacy, Lippincott Williams, New Delhi.
  1. Carter S.J., Cooper and Gunn’s. Tutorial Pharmacy, CBS Publications, New Delhi.
  2. E.A. Rawlins, Bentley’s Text Book of Pharmaceutics, English Language Book Society, Elsevier Health Sciences, USA.
  1. Isaac Ghebre Sellassie: Pharmaceutical Pelletization Technology, Marcel Dekker, INC, New York.
  1. Dilip M. Parikh: Handbook of Pharmaceutical Granulation Technology, Marcel Dekker, INC, New York.
  1. Francoise Nieloud and Gilberte Marti-Mestres: Pharmaceutical Emulsions and Suspensions, Marcel Dekker, INC, New York.

Session Plan

Session 1

History of profession of Pharmacy in India in relation to pharmacy education, industry and organization, Pharmacy as a career.

Historical background and development of profession of pharmacy

Session 2

Pharmacopoeias: Introduction to IP, BP, USP and Extra Pharmacopoeia.

Historical background and development of profession of pharmacy

Session 3

Introduction to dosage forms, classification and definitions.

 

Introduction-to-dosage-forms

Session 4

Prescription: Definition, Parts of prescription, handling of Prescription and Errors in prescription.

 

Prescription

Session 5

Posology: Definition, factors affecting posology.

 

Posology

Session 6

Pediatric dose calculations based on age, body weight and body surface area.

Posology

Session 7

Pharmaceutical calculations: Weights and measures – Imperial & Metric System.

Pharmaceutical calculations

Session 8

Pharmaceutical calculations: Calculations involving percentage solutions, allegation.

Pharmaceutical calculations

Session 9

Pharmaceutical calculations: proof spirit and isotonic solutions based on freezing point and molecular weight.

Pharmaceutical calculations

Session 10

Powders: Definition, classification, advantages and disadvantages, Simple & compound powders.

Powders

Session 11

Preparation of dusting powders, effervescent powders, and efflorescent.

 

Powders

Session 12

Preparation of hygroscopic powders and eutectic mixtures.

Powders

Session 13

Geometric dilution.

Powders

Session 14

Introduction to liquid dosage forms. Advantages and disadvantages of liquid dosage forms.

Session 15

Introduction to monophasic dosages form. Definitions and preparations of Gargles, Mouthwashes, Throat Paint.

Monophasic liquids

Session 16

Definitions and preparations of Eardrops, Nasal drops, Enemas.

Monophasic liquids

Session 17

Definitions and preparations of Syrups, Elixirs, Liniments, and Lotions.

Monophasic liquids

Session 18

Introduction to biphasic liquid dosages form.

Session 19

Suspensions: Definition, advantages, and disadvantages, classifications.

Session 20

Preparation of suspensions; Flocculated and Deflocculated suspension.

Session 21

Suspensions: stability problems and methods to overcome.

Session 22

Emulsions: Definition, classification, emulsifying agent.

Session 23

Methods of preparation of Emulsion, test for the identification.

Session 24

Methods of preparation of Emulsion, test for the identification.

Session 25

Emulsions stability problems and methods to overcome.

Session 26

Suppositories: Definition, Types, advantages, and disadvantages.

Session 27

Types of bases, methods of preparations of suppositories.

Session 28

Pharmaceutical incompatibilities: Definition, classification.physical, chemical, and therapeutic incompatibilities with examples.

Session 29

Semisolid dosage forms: Definitions, classification.

Mechanisms and factors influencing dermal penetration of drugs.

Preparation of ointments, pastes, creams, and gels.

Session 30

Excipients used in semi-solid dosage forms.

Evaluation of semi-solid dosages forms.

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