Pharmaceutics- I (Theory)

Teacher

Mr. Rudra Narayan Sahoo

Category

Core Courses

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Course Name : Pharmaceutics I (Theory)

 

 

Code(Credit) : BPHT1103(4-0-0)

Course Objectives

  • This course is designed to impart a fundamental knowledge on the preparatory pharmacy with arts and science of preparing the different conventional dosage forms.

Learning Outcomes

Upon completion of this course the student should be able to:

    1. Know the history of the profession of pharmacy.
    2. Understand the basics of different dosage forms, pharmaceutical incompatibilities, and pharmaceutical calculations.
    3. Understand the professional way of handling the prescription.
    4. Preparation of various conventional dosage forms.

Course Syllabus

MODULE – I

  • Historical background and development of profession of pharmacy: History of profession of Pharmacy in India in relation to pharmacy education, industry and organization, Pharmacy as a career, Pharmacopoeias: Introduction to IP, BP, USP and Extra Pharmacopoeia.
  • Dosage forms: Introduction to dosage forms, classification and definitions
  • Prescription: Definition, Parts of prescription, handling of Prescription and Errors in prescription.
  • Posology: Definition, Factors affecting posology. Pediatric dose calculations based on age, body weight and body surface area.

 

MODULE – II

  • Pharmaceutical calculations: Weights and measures – Imperial & Metric system, Calculations involving percentage solutions, alligation, proof spirit and isotonic solutions based on freezing point and molecular weight.
  • Powders: Definition, classification, advantages and disadvantages,Simple & compound powders – official preparations, dusting powders, effervescent, efflorescent and hygroscopic powders, eutectic mixtures. Geometric dilutions.
  • Liquid dosage forms: Advantages and disadvantages of liquid dosage forms. Excipients used in formulation of liquid dosage forms. Solubility enhancement techniques.

 

MODULE – III

  • Monophasic liquids: Definitions and preparations of Gargles, Mouthwashes, Throat Paint, Eardrops, Nasal drops, Enemas, Syrups, Elixirs, Liniments and Lotions.
  • Biphasic liquids:
  • Suspensions: Definition, advantages and disadvantages, classifications, Preparation of suspensions; Flocculated and Deflocculated suspension & stability problems and methods to overcome.
  • Emulsions: Definition, classification, emulsifying agent, test for the identification of type of Emulsion, Methods of preparation & stability problems and methods to overcome.

 

MODULE – IV

  • Suppositories: Definition, types, advantages and disadvantages, types of bases, methods of preparations. Displacement value & its calculations, evaluation of suppositories.
  • Pharmaceutical incompatibilities: Definition, classification, physical, chemical and therapeutic incompatibilities with examples.

 

MODULE – V

  • Semisolid dosage forms: Definitions, classification, mechanisms and factors influencing dermal penetration of drugs. Preparation of ointments, pastes, creams and gels. Excipients used in semi solid dosage forms. Evaluation of semi solid dosages forms.

 

Recommended Books:

  1. H.C. Ansel et al., Pharmaceutical Dosage Form and Drug Delivery System, Lippincott Williams andWalkins, New Delhi.
  1. Carter S.J., Cooper and Gunn’s-Dispensing for Pharmaceutical Students, CBS publishers, New Delhi.
  1. M.E. Aulton, Pharmaceutics, The Science& Dosage Form Design, Churchill Livingstone, Edinburgh.
  1. Indian pharmacopoeia.
  2. British pharmacopoeia.
  3. Lachmann. Theory and Practice of Industrial Pharmacy,Lea& Febiger Publisher, The University of Michigan.
  1. Alfonso R. Gennaro Remington. The Science and Practice of Pharmacy, Lippincott Williams, New Delhi.
  1. Carter S.J., Cooper and Gunn’s. Tutorial Pharmacy, CBS Publications, New Delhi.
  2. E.A. Rawlins, Bentley’s Text Book of Pharmaceutics, English Language Book Society, Elsevier Health Sciences, USA.
  1. Isaac Ghebre Sellassie: Pharmaceutical Pelletization Technology, Marcel Dekker, INC, New York.
  1. Dilip M. Parikh: Handbook of Pharmaceutical Granulation Technology, Marcel Dekker, INC, New York.
  1. Francoise Nieloud and Gilberte Marti-Mestres: Pharmaceutical Emulsions and Suspensions, Marcel Dekker, INC, New York.

Session Plan

Session 1

History of profession of Pharmacy in India in relation to pharmacy education, industry and organization, Pharmacy as a career.

HISTORY OF PHARMACY

Session 2

Pharmacopoeias: Introduction to IP, BP, USP and Extra Pharmacopoeia.

Pharmacopoeia

Session 3

Introduction to dosage forms, classification and definitions.

DOSAGE FORM

https://www.youtube.com/watch?v=fx6rFbYCIAA

Session 4

Prescription: Definition, Parts of prescription, handling of Prescription and Errors in prescription.

Prescription

https://www.youtube.com/watch?v=Twb7UOM1jrY

Session 5

Posology: Definition, factors affecting posology.

Posology

https://www.youtube.com/watch?v=6r86n1r-LRQ

Session 6

Pediatric dose calculations based on age, body weight and body surface area.

Pediatric dose calculations

Session 7

Pharmaceutical calculations: Weights and measures – Imperial & Metric System.

Pharmaceutical calculations

Session 8

Pharmaceutical calculations: Calculations involving percentage solutions, allegation.

Pharmaceutical calculations

Session 9

Pharmaceutical calculations: proof spirit and isotonic solutions based on freezing point and molecular weight.

Pharmaceutical calculation

Session 10

Powders: Definition, classification, advantages and disadvantages, Simple & compound powders.

Pharmaceutical powders

Session 11

Preparation of dusting powders, effervescent powders, and efflorescent.

Pharmaceutical powders preparation

https://www.youtube.com/watch?v=5S1D2v5tMsM

Session 12

Preparation of hygroscopic powders and eutectic mixtures.

Pharmaceutical powders

Session 13

Session 14

Introduction to liquid dosage forms. Advantages and disadvantages of liquid dosage forms.

Liquid dosages form

Session 15

Excipients used in the formulation of liquid dosage forms.

Excipients used in liquid dosages form

Session 16

Solubility enhancement techniques in liquid dosages form.

Solubility enhancement techniques

Session 17

Introduction to monophasic dosages form. Definitions and preparations of Gargles, Mouthwashes, Throat Paint.

Monophasic liquid dosage form

Session 18

Definitions and preparations of Eardrops, Nasal drops, Enemas.

Monophasic liquid dosage form preparation

Session 19

Definitions and preparations of Syrups, Elixirs, Liniments, and Lotions.

Definitions and preparations of Syrups, Elixirs, Liniments, and Lotions.

Session 20

Introduction to biphasic liquid dosages form.

Biphasic liquid dosage form

Session 21

Suspensions: Definition, advantages, and disadvantages, classifications.

Suspensions

Session 22

Preparation of suspensions; Flocculated and Deflocculated suspension.

Preparation of Suspension

Session 23

Suspensions: stability problems and methods to overcome.

Stability of Suspensions

Session 24

Emulsions: Definition, classification, emulsifying agent.

EMULSION

Session 25

Methods of preparation of Emulsion, test for the identification.

Method of preparation of Emulsion

Session 26

Methods of preparation of Emulsion, test for the identification.

Method of preparation of Emulsion

Session 27

Emulsions stability problems and methods to overcome.

STABILITY OF EMULSION

Session 28

Suppositories: Definition, Types, advantages, and disadvantages.

SUPPOSITORIES

Session 29

Types of bases, methods of preparations of suppositories.

SUPPOSITORY BASES

Session 30

Displacement value & its calculations.

https://www.youtube.com/watch?v=pzqwEAN-NIE

Session 31

Evaluation of suppositories.

Evaluation of suppositories

Session 32

Pharmaceutical incompatibilities: Definition, classification.physical, chemical, and therapeutic incompatibilities with examples.

pharmaceutical incompatibility

Session 33

Semisolid dosage forms: Definitions, classification.

SEMISOLID DOSAGE FORMS

Session 34

Mechanisms and factors influencing dermal penetration of drugs.

Factors affecting tdds

Session 35

Preparation of ointments, pastes, creams, and gels.

PREPARATION OF OINTMENTS

Session 36

Excipients used in semi-solid dosage forms.

Excipients for Liquid and Semisolid Dosage Forms

Session 37

Evaluation of semi-solid dosages forms.

Evaluation of semisolid dosage forms

Case Studies

Case Studies

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