Pharmaceutical chemistry-I (Diploma 1st year)
Teacher
KAMINI SETHY
Category
Core Courses
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Course Name : Pharmachemistry-I
Credit(code) : DCPY1102(3-3-0)
Course Objectives
The objective is to make understand about 1)principles of limit tests.2)Familiar with different classes of inorganic pharmaceuticals 3)Identification of different anions, cations and different inorganic pharmaceuticals. 4) Knowledge about the sources of impurities and methods to determine the impurities in inorganic drugs and pharmaceuticals 5)understand the medicinal and pharmaceutical importance of inorganic compounds 6) To have been introduced to a variety of inorganic drug classes.
Learning Outcomes
Upon completion of the course the students shall be able to understand the application of inorganic pharmaceutical compounds.They will Explain the effects of impurities in pharmaceuticals.Describe the principles and methods of limit tests to control common impurities in pharmaceutical substances.Explain different pharmaceutical buffers, their preparations, uses in pharmaceutical system,measurement of tonicity.Explain the medicinal importance of pharmaceutical inorganic compounds.
Syllabus
MODULE 1
1. General discussion on the following inorganic compounds including important physical
and chemical properties, medicinal and Pharmaceutical uses, storage conditions and
chemical incompatibility.
A. Acids, bases and buffers Boric acid*, Hydrochloric acid, strong ammonium
hydroxide, Calcium hydroxide, Sodium hydroxide and official buffers.
B. Antioxidants,Hypophosphorous acid, Sulphur dioxide, Sodium bisulphite,
Sodium metabisulphite, Sodium thiosulphate, Nitrogen and Sodium Nitrite.
C. Gastrointestinal agents:
i)Acidifying agents dil.hydrochloric acid
ii)Antacids sodium bicarbonate,aluminium hydroxide gel,aluminium phosphate,calcium carbonate,magnesium carbonate,magnesium trisilicate,magnesium oxide,combinations of antacid preparations
iii)protectives and adsorbents bismuth subcarbonate and kaolin
saline cathartics-sodium potassium tartarate and magnesium sulphate
D. Topical Agents:
i)protectives-talc,zinc oxide,calamine,zinc stearate,titanium dioxide,silicone polymers
ii)antimicrobials and astringents-hydrogen peroxide,potassium permanganate,chlorinated line,iodine,iodine solutions,povidone iodine,boric acid,borax,silver nitrate,mild silver protein,mercury,yellow mercuric oxide,ammoniated mercury,
iii)sulphur and its compounds sublimed sulphur precipitated sulphur,selenium sulphide
iv)Astringents alum and zinc sulphate
E. Dental Products,Sodium Fluride, Stannous Flouride, Calcium carbonate,permanganate, Chlorinated lime, Iodine, Solutions of Iodine, Povidone-iodine,
Sodium metaphosphate, Dicalcium phosphate, Strontium chloride, Zinc chloride.
MODULE 2
F. Inhalants,Oxygen, Carbon dioxide, Nitrous oxide.
G. Respiratory stimulants,Ammonium Carbonate.
H. Expectorants and Emetics,Ammonium chloride , *Potassium iodide, Antimony
potassium tartrate.
I. Antidotes-Sodium nitrate.
2. Major Intra and Extracellular electrolytes:
A. Electrolytes used for replacement therapy-Sodium chloride and its
preparations, Potassium chloride and its preparations.
B. Physiological acid-base balance and electrolytes used-Sodium acetate, Potassium
acetate, Sodium bicarbonate injection, Sodium citrate, Potassium citrate, Sodium
lactate injection, Ammonium chloride and its injection.
C. Combination of oral electrolyte powders and solutions.
3. Inorganic Official compounds of Iron, Iodine, and, Calcium Ferrous Sulfate and
Calcium gluconate.
4. Radio pharmaceuticals and Contrast media-Radio activity-Alpha, Beta and
Gamma Radiations, Biological effects of radiations, Measurement of radio activity, G.
M. Counter Radio isotopes their uses, storage and precautions with special reference to
the official preparations. Radio opaque Contrast media, Barium sulfate.
5. Quality control of Drugs and Pharmaceuticals-Importance of quality control,
significant errors, methods used for quality control, sources of impurities in Pharmaceuticals,
Limit tests for Arsenic, chloride, sulphate, Iron and Heavy metals.
6. Identification tests for cations and anions as per Indian Pharmacopoei a
References
- Inorganic pharmaceutical Chemistry by G.R Chatwal
- Text book of inorganic pharmaceutical chemistry-I by Mohammed Ali
- Concise inorganic pharmaceutical chemistry by Dr.K.R Mahadik,Dr.B.S Kuchekar
Session 2
Hydrochloric acid, strong ammonium
hydroxide,hydrochloric acid and strong ammonium hydroxide-converted
Session 10
| Acidifying agents Dilute hydrochloric acid |
Session 11
|
|||||||||||
Session 16
| Magnesium oxide, Combinations of antacid preparations. |
Session 19
| Saline Cathartics-Sodium potassium tartrate and Magnesium sulphate. |
Session 26
| Potassium |
permanganate, Chlorinated lime, potassium permanganate,chlorinated lime-converted
Session 31
| Â Yellow mercuric oxide, Ammoniated mercury | . |
Session 37
Sodium metaphosphate, Dicalcium phosphate,sodium metaphosphate,dicalcium phosphate-converted
Session 41
Respiratory stimulants,Ammonium Carbonate.
http://https://pharmacareacademy.blogspot.com/2018/06/respiratory-stimulant.html
Session 42
Expectorants and Emetics,Ammonium chloride , expectorant and emetics,ammonium chloride-converted
Session 43
Potassium iodide, Antimony
potassium tartrate.potassium iodide,antimony potassium tartarate-converted
Session 44
Electrolytes used for replacement therapy-Sodium chloride and its
preparations, electrolytes,sodium chloride-converted
Session 46
physiological acid-base balance and electrolytes used-Sodium acetate, Potassium
acetate, Sodium bicarbonate injection,physiological acid base balance
Session 47
physiological acid-base balance and electrolytes used-Sodium acetate, Potassium
acetate, Sodium bicarbonate injection,
Session 48
Sodium citrate, Potassium citrate, Sodium
lactate injection,
Session 49
Ammonium chloride and its injection
Session 50
Combination of oral electrolyte powders and solutions
Session 51
Inorganic Official compounds of Iron, Iodine, and, Calcium Ferrous Sulfate and
Calcium gluconateofficial preparation of iron iodine and calcium-converted-converted
Session 52
Inorganic Official compounds of Iron, Iodine, and, Calcium Ferrous Sulfate and
Calcium gluconate
Session 54
biological effect of radiations
Session 55
Radio activity-Alpha, Beta and
Gamma Radiations
see session 53
Session 57
Radio isotopes their uses, storage and precautions with special reference to
the official preparations.
Session 58
Radio opaque Contrast media, Barium sulfate.
see session 53
Session 59
Radio isotopes their uses, storage and precautions with special reference to
the official preparations.
Session 60
mportance of quality control,
significant errors
Session 61
methods used for quality control,
Session 62
sources of impurities in Pharmaceuticals
Session 65
Limit tests for Arsenic
Session 69
limit test for heavy metals
Session 70
limit test for heavy metals
Session 71
Identification tests for cations
Session 72
Identification tests for cations
Session 73
Identification tests for anions
Case Studies
Case Studies
Course Name : pharmachemistry-I
DCPY1102(2)
Course Objectives
To make students understand how small impurities can be detected through limit tests.Qualitative identifications of cations and anions in pharmaceutical substances and analysis of purity of inorganic compounds
Learning Outcomes
The students will be well acquinted with the principle of limit tests, different classes of inorganic pharmaceuticals and their analysis and identification of different anions, cations and different inoganic pharmaceuticals.
Course Syllabus
1.Identification tests for inorganic compounds particularly drugs and pharmaceuticals.
2. Limit test for chloride, sulfate, Arsenic, Iron and Heavy metals.
3. Assay of inorganic Pharmaceuticals involving each of the following methods of
compounds marked with (*) under theory.
a. Acid-Base titrations (at least 3)
b. Redox titrations (One each of Permanganometry and iodimetry)
c. Precipitation titrations (at least 2)
d. Complexometric titrations (Calcium and Magnesium)
Session Plan
Experiment 1
Identification test for ferrous sulphateidentification test for ferrous sulphate
Experiment 2
Identification test for barium chloride
Experiment 5
Identification test for magnesium hydroxide
Experiment 6
Identification test for calcium gluconate
Experiment 18
Assay of sodium chloride
Case Studies
Case Studies
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