PHYSICAL PHARMACEUTICS-II (Theory)
Teacher
Nihar Ranjan Kar
Category
Course Attendees
Still no participant
Course Reviews
Still no reviews
Course Objectives
Upon the completion of the course student shall be able to
1. Understand various physicochemical properties of drug molecules in the designing the dosage forms
2. Know the principles of chemical kinetics & to use them for stability testing nad determination of expiry date of formulations
3. Demonstrate use of physicochemical properties in the formulation development and evaluation of dosage forms
Course Outcomes
| CO | OUTCOMES | PO MAPPING |
| CO1 | Upon the completion of the course student shall be able to:
Solubility of drugs
|
PO1 |
| CO2 | Understand various physicochemical properties of drug molecules in the designing the dosage form | PO1,PO,PO3 |
| CO3 | Know the principles of chemical kinetics & to use them in assigning expiry date for formulation | PO1,PO11 |
| CO4 | Demonstrate use of physicochemical properties in evaluation of dosage forms. | PO1,PO5 |
| CO5 | Appreciate physicochemical properties of drug molecules in formulation research and development. | PO1,PO2,PO3 |
Course Syllabus
Module-I
Colloidal dispersions: Classification of dispersed systems & their general characteristics, size & shapes of colloidal particles, classification of colloids & comparative account of their general properties. Optical, kinetic & electrical properties. Effect of electrolytes, coacervation, peptization& protective action.
Module-II
Rheology: Newtonian systems, law of flow, kinematic viscosity, effect of temperature, non-Newtonian systems, pseudoplastic, dilatant, plastic, thixotropy, thixotropy in formulation, determination of viscosity, capillary, falling Sphere, rotational viscometers Deformation of solids: Plastic and elastic deformation, Heckel equation, Stress, Strain, Elastic Modulus
Module--III
Coarse dispersion: Suspension, interfacial properties of suspended particles, settling in suspensions, formulation of flocculated and deflocculated suspensions. Emulsions and theories of emulsification, microemulsion and multiple emulsions; Stability of emulsions, preservation of emulsions, rheological properties of emulsions and emulsion formulation by HLB method.
Module-IV
Micromeretics: Particle size and distribution, mean particle size, number and weight distribution, particle number, methods for determining particle size by different methods, counting and separation method, particle shape, specific surface, methods for determining surface area, permeability, adsorption, derived properties of powders, porosity, packing arrangement, densities, bulkiness & flow properties.
Module-V
Drug stability: Reaction kinetics: zero, pseudo-zero, first & second order, units of basic rate constants, determination of reaction order. Physical and chemical factors influencing the chemical degradation of pharmaceutical product: temperature, solvent, ionic strength, dielectric constant, specific & general acid base catalysis, Simple numerical problems. Stabilization of medicinal agents against common reactions like hydrolysis & oxidation. Accelerated stability testing in expiration dating of pharmaceutical dosage forms. Photolytic degradation and its prevention
REFERENCES
1. Physical Pharmacy by Alfred Martin, Sixth edition
2. Experimental pharmaceutics by Eugene, Parott.
3. Tutorial pharmacy by Cooper and Gunn.
4. Stocklosam J. Pharmaceutical calculations, Lea & Febiger, Philadelphia.
5. Liberman H.A, Lachman C., Pharmaceutical Dosage forms, Tablets, Volume-1 to 3, Marcel Dekkar Inc.
6. Liberman H.A, Lachman C, Pharmaceutical dosage forms. Disperse systems, volume 1, 2, 3. Marcel Dekkar Inc.
7. Physical Pharmaceutics by Ramasamy C, and Manavalan R.
Session Plan
Session-1
Classification of dispersed systems
Session-11
Stabilisation,protective Action and Application of colloids
sensitizationandprotectivecolloidalaction-190511082908
Session-12
Introduction,Concept of Viscosity,Types of Viscosity
Session-15
Plastic Flow,Pseudoplastic Flow and Dilatant Flow
Session-16
Thixotropy and measurement of thixotropy
Session-20
Plastic deformation,Elastic deformation
Session-23
Suspension, Classification
Session-25
Interfacial Properties of suspended particles
Session-30
Emulsion,Classification
Session-34
rheological properties of emulsions and emulsion formulation by HLB method
Session-36
mean particle size, number and weight distribution, particle number
Session-37
methods for determining particle size by different methods
Session-45
Reaction kinetics: zero, pseudo-zero, first & second order
Session-47
Physical and chemical factors influencing the chemical degradation of pharmaceutical product: temperature
Session-48
Physical and chemical factors influencing the chemical degradation of pharmaceutical product: solvent,ionic strength
Session-49
Physical and chemical factors influencing the chemical degradation of pharmaceutical product: dielectric constant, specific & general acid base catalysis
Session-53
Accelerated stability testing in expiration dating of pharmaceutical dosage forms
Our Main Teachers