PHYSICAL PHARMACEUTICS-II (Theory)

Teacher

Nihar Ranjan Kar

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COURSE NAME-PHYSICAL PHARMACEUTICS-II(Theory)

COURSE CODE-BPHT2202(4-0-0)

Course Objectives

Upon the completion of the course student shall be able to

1. Understand various physicochemical properties of drug molecules in the designing the dosage forms

2. Know the principles of chemical kinetics & to use them for stability testing nad determination of expiry date of formulations

3. Demonstrate use of physicochemical properties in the formulation development and evaluation of dosage forms

Course Outcomes

CO OUTCOMES PO MAPPING
CO1 Upon the completion of the course student shall be able to:

Solubility of drugs

 

PO1
CO2 Understand various physicochemical properties of drug molecules in the designing the dosage form PO1,PO,PO3
CO3 Know the principles of chemical kinetics & to use them in assigning expiry date for formulation PO1,PO11
CO4 Demonstrate use of physicochemical properties in evaluation of dosage forms. PO1,PO5
CO5 Appreciate physicochemical properties of drug molecules in formulation research and development. PO1,PO2,PO3

Course Syllabus

Module-I

Colloidal dispersions: Classification of dispersed systems & their general characteristics, size & shapes of colloidal particles, classification of colloids & comparative account of their general properties. Optical, kinetic & electrical properties. Effect of electrolytes, coacervation, peptization& protective action.

Module-II

Rheology: Newtonian systems, law of flow, kinematic viscosity, effect of temperature, non-Newtonian systems, pseudoplastic, dilatant, plastic, thixotropy, thixotropy in formulation, determination of viscosity, capillary, falling Sphere, rotational viscometers Deformation of solids: Plastic and elastic deformation, Heckel equation, Stress, Strain, Elastic Modulus

Module--III

Coarse dispersion: Suspension, interfacial properties of suspended particles, settling in suspensions, formulation of flocculated and deflocculated suspensions. Emulsions and theories of emulsification, microemulsion and multiple emulsions; Stability of emulsions, preservation of emulsions, rheological properties of emulsions and emulsion formulation by HLB method.

Module-IV

Micromeretics: Particle size and distribution, mean particle size, number and weight distribution, particle number, methods for determining particle size by different methods, counting and separation method, particle shape, specific surface, methods for determining surface area, permeability, adsorption, derived properties of powders, porosity, packing arrangement, densities, bulkiness & flow properties.

Module-V

Drug stability: Reaction kinetics: zero, pseudo-zero, first & second order, units of basic rate constants, determination of reaction order. Physical and chemical factors influencing the chemical degradation of pharmaceutical product: temperature, solvent, ionic strength, dielectric constant, specific & general acid base catalysis, Simple numerical problems. Stabilization of medicinal agents against common reactions like hydrolysis & oxidation. Accelerated stability testing in expiration dating of pharmaceutical dosage forms. Photolytic degradation and its prevention

REFERENCES

1. Physical Pharmacy by Alfred Martin, Sixth edition

2. Experimental pharmaceutics by Eugene, Parott.

3. Tutorial pharmacy by Cooper and Gunn.

4. Stocklosam J. Pharmaceutical calculations, Lea & Febiger, Philadelphia.

5. Liberman H.A, Lachman C., Pharmaceutical Dosage forms, Tablets, Volume-1 to 3, Marcel Dekkar Inc.

6. Liberman H.A, Lachman C, Pharmaceutical dosage forms. Disperse systems, volume 1, 2, 3. Marcel Dekkar Inc.

7. Physical Pharmaceutics by Ramasamy C, and Manavalan R.

Session Plan

Session-1

Classification of dispersed systems

session -1

https://www.youtube.com/watch?v=6xVADcIfdVs

Session-2

Characteristics of Dispersed System

session-2

https://www.youtube.com/watch?v=-RtSbWxnMoI

Session-3

size & shapes of colloidal particles

session-3

Session-4

classification of colloids

session 4

https://www.youtube.com/watch?v=cK6bNWOd_OI

Session-5

Optical properties of Colloids

session 5

Session-6

Kinetic Properties of Colloids

session 6

https://www.youtube.com/watch?v=h150OKCfRjk

Session-7

Electrical Properties of Colloids

session 7

https://www.youtube.com/watch?v=nImZaURueoY

Session-8

Preparation of colloids

session -8

Session-9

Purification of Colloids

session -9

Session-10

Instability of Colloids

session-10

Session-12

Introduction,Concept of Viscosity,Types of Viscosity

session-12

https://www.youtube.com/watch?v=51hAeFPP57s

Session-13

Kinematic Viscosity,Relative Viscosity,Intrinscic Viscosity,Reduced Viscosity

session-13

Session-14

Newton's Law of Flow,Newtonial System

session-14

Session-15

Plastic Flow,Pseudoplastic Flow and Dilatant Flow

session -15

https://www.youtube.com/watch?v=ILl_eJdBbUI

Session-16

Thixotropy and measurement of thixotropy

session-16

 

https://www.youtube.com/watch?v=YMQMpi-E2RY

Session-17

Capillary Viscometers

session-17

https://www.youtube.com/watch?v=Bl1LblcVH9Y

Session-18

Falling Sphere Viscometers

session-18

Session-19

Rotational Viscometers

session-19

Session-20

Plastic deformation,Elastic deformation

deformation of solids

https://www.youtube.com/watch?v=DlPvHTnGPkI

Session-21

Stress,Strain

deformation of solids

Session-22

Heckel equation and Elastic Modulus

deformation of solids

Session-24

flocculated and deflocculated suspensions

Flocculated and Deflocculated Suspension

Session-25

Interfacial Properties of suspended particles

Interfacial properties of Suspended Particless

Session-26

Surface Free Energy,Surface Potential

session -26

Session-27

Settling of Suspensions,theory of Sedimentation

settling of suspensions (1)

Session-28

Fomulation of Flocculated and Deflocculated Suspension

Formulation of suspension

Session-29

Structured Vehicle,Controlled Flocculation

Controlled flocculation

Session-31

Theories of emulsification

theories of emulsification (1)

Session-32

microemulsion and multiple emulsions

micro and multiple emulsion

Session-33

Stability of emulsions, preservation of emulsions

stability of emulsion

Session-34

rheological properties of emulsions and emulsion formulation by HLB method

fomulation of emulsion 1

Session-35

Particle size and distribution

particle sizes

Session-36

mean particle size, number and weight distribution, particle number

size distribution

https://www.youtube.com/watch?v=Zitpu65eDMs

Session-37

methods for determining particle size by different methods

methods of determination of particle size 1

Session-38

counting and separation method

methods of determination of particle size 2

Session-39

particle shape, specific surface

particle shape, specific surface

Session-40

methods for determining surface area

determination of specific surface

Session-41

permeability, adsorption

determination of specific surface

Session-42

derived properties of powders

derived properties of powder

Session-43

porosity, packing arrangement

derived properties of powder

Session-44

densities, bulkiness & flow properties

derived properties of powder

Session-45

Reaction kinetics: zero, pseudo-zero, first & second order

chemical kinetics-order of the reaction

Session-46

units of basic rate constants, determination of reaction order

determination of order

Session-47

Physical and chemical factors influencing the chemical degradation of pharmaceutical product: temperature

session-47

Session-48

Physical and chemical factors influencing the chemical degradation of pharmaceutical product: solvent,ionic strength

session-48

Session-49

Physical and chemical factors influencing the chemical degradation of pharmaceutical product: dielectric constant, specific & general acid base catalysis

session-49

Session-50

Simple numerical problems related to Reaction Kinetics

session-50

Session-51

Stabilization of medicinal agents against common reactions like hydrolysis

session-51

Session-52

Stabilization of medicinal agents against common reactions like oxidation

session-52

Session-53

Accelerated stability testing in expiration dating of pharmaceutical dosage forms

session-53

Session-54

Photolytic degradation and its prevention

session-54

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