Toxicology
Teacher
Dr. Atia Arzoo
Category
Core Courses
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Course Name : Toxicology
Code(Credit) : CUTM1420(3-1-0)
Course Objectives
- To give students knowledge and skill that allow an overall assessment of the fate of foreign chemicals in the environment and of their effects on different biological organization levels.
- To develop a conceptual framework to identify toxins and its remedies.
Learning Outcomes
On the completion of the course, the student should be able to:
- describe sources and fates of chemicals in the environment
- present and explain mechanisms for adverse effects of chemicals
- estimate the risk for adverse effects of a chemical on different biological organization levels based on knowledge about the toxicity, degradability and bioavailability of the chemical
- retrieve and critically evaluate toxicological information from different sources (internet based databases, hand books, scientific articles)
- independently identify the toxins present in the environment and evaluate the environmental risk assessment
Course Syllabus
Module-1
Concepts of toxicology: Introduction to toxicology, Background of Toxicology, Toxicology for the Twenty-First Century, Acute, sub acute and chronic toxicity.
Practice-1: Action of antibiotics on micro-organisms
Practice-2: Minimum Inhibitory Concentration (MIC) Testing
Module-2
Toxicity Pathways: Adverse Outcome Pathways (AOPs), Exposure-Based Chemical Prioritization, ER Bioactivity Model, US EPA Endocrine Disruptor Screening Program (EDSP).
Module-3
Toxicity mechanism: Mechanistic Toxicology and Pathway Mapping at the Basics of 21st Century Toxicology, The Concept of the Human Toxome Project, Concept and Tool Development, Omics Technologies and High-Throughput Data.
Module- 4
Integrated Testing Strategies: Why Integrated Testing Strategies? And Strategies for Integrated Testing Strategies, What is an Integrated Testing Strategy?, How to Compose Integrated Testing Strategies, Quality Assurance of integrated Testing Strategies
Module-5
Toxicity beyond chemicals: Legal Background, Economic Background, Tox-21c for Drug Safety, Green Toxicology as Non-regulatory Tox-21c Approaches
Module-6
Ecotoxicology and Risk assessment: Toxicants in air, Toxicants in water, Toxicants in soil, Heavy metal toxicity and its risk assessment.
Practice-3: Water Quality Testing Methods
Practice-4: Determination of heavy metals in soil
Module-7
Toxicity remediation and Application of toxicants: Replacement of synthetic fertilizer by Biofertilizer, Solid waste management, Bioremediation, Uses of toxins as Nanomedicines, Bioherbicides, Biopesticides.
Practice-5: Preparation of biofertilizer
Practice-6: Bio-remediation - Cleaning a Mixture of Oil & Water/Phytoremediation of heavy metals from soil or water.
Recommended Books:
- Walker, C.H., S.P. Hopkin, R. M. Sibley, and D.P. Peakall. 2012. Principles of Ecotoxicology, Fourth Edition. Boca Raton, FL: CRC Press. ISBN -13: 978-1-4398-6266-7 (soft cover)
- Newman, M.C. 2014. Fundamentals of Toxicology. 4th Edition. Boca Raton, FL: CRC Press. (Selected Chapters)
- Newman, M.C. & W.H. Clements. 2008. Ecotoxicology: A Comprehensive Treatment. Boca Raton, FL: CRC Press. (Selected Chapters) Pennings,
- S.C. and M. D. Bertness. 2001. Salt Marsh Communities. In: Marine Community Ecology.
- M. D. Bertness, S.D. Gaines, and M. Hay (Editors). Sinauer Associates, Sunderland Massachusetts.
Session Plan
Session 1
Session 3
Toxicology for the Twenty-First Century
https://www.coursera.org/lecture/toxicology-21/toxicology-for-the-twenty-first-century-KOsqI
Session 4
Acute, sub accute and chronic toxicity
https://www.slideshare.net/Sindhukuberappa/acute-sub-acute-chronic-toxicological-studi
Session 5 (Practice) 2 hours
Action of antibiotics on micro-organisms
Session 6 (Practice) 2 hours
Minimum Inhibitory Concentration (MIC) Testing
Session 7
Adverse Outcome Pathways (AOPs)
https://www.coursera.org/learn/toxicology-21/lecture/kQ7UH/adverse-outcome-pathways-aops
Session 8
Exposure-Based Chemical Prioritization
https://www.coursera.org/lecture/toxicology-21/exposure-based-chemical-prioritization-9Us95
Session 9
ER Bioactivity Model
https://www.coursera.org/lecture/toxicology-21/er-bioactivity-model-9CrWV
Session 10
US EPA Endocrine Disruptor Screening Program (EDSP)
Session 11
Mechanistic Toxicology and Pathway Mapping at the Basics of 21st Century Toxicology
Session 12
The Concept of the Human Toxome Project
https://www.coursera.org/learn/toxicology-21/lecture/2zaYP/the-concept-of-the-human-toxome-project
Session 13
Concept and Tool Devlopment
https://www.coursera.org/lecture/toxicology-21/concept-and-tool-devlopment-luOQi
Session 14
Omics Technologies and High-Throughput Data
https://www.coursera.org/lecture/toxicology-21/omics-technologies-and-high-throughput-data-zK0JN
Session 15
Why Integrated Testing Strategies? And Strategies for Integrated Testing Strategies
https://www.coursera.org/lecture/toxicology-21/why-integrated-testing-strategies-LGGs0
Session 16
What is an Integrated Testing Strategy?
https://www.coursera.org/lecture/toxicology-21/what-is-an-integrated-testing-strategy-Ujh1P
Session 17
How to Compose Integrated Testing Strategies
https://www.coursera.org/lecture/toxicology-21/how-to-compose-integrated-testing-strategies-02M9t
Session 18
Quality Assurance of integrated Testing Strategies
Session 19
Session 20
Economic Background
https://www.coursera.org/lecture/toxicology-21/economic-background-OmKFI
Session 21
Tox-21c for Drug Safety
https://www.coursera.org/lecture/toxicology-21/tox-21c-for-drug-safety-33c5O
Session 22
Green Toxicology as Non-regulatory Tox-21c Approaches
Session 24
Session 25
Session 26
Session 27 (Practice) 2 hours
Water Quality Testing Methods
Session 28 (Practice) 2 hours
Determination of heavy metals in soil
Session 29
Replacement of synthetic fertilizer by Biofertilizer
Session 30
Session 33
Session 34
Session 35 (Practice) 2 hours
Preparation of biofertilizer
Session 36 (Practice) 2 hours
Bio-remediation - Cleaning a Mixture of Oil & Water
Case Studies
Case Studies
Our Main Teachers
Dr. Atia Arzoo is having academic training and research experience primarily in the field of Environmental sciences enables her to be an effective faculty in the Department of Environmental Science. She has qualified her Ph.D. degree in Environmental Sciences. Her areas of research and consulting interest include environmental pollution control and management specially in the […]