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The objectives of the course are
Apply surface tension and complexation principles in drug formulation.
Upon the completion of the course student shall be able to
Unit I
Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors influencing solubility of drugs, Dissolution & drug release, diffusion principles in biological systems. Solubility of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law, real solutions, azeotropic mixtures, fractional distillation. Partially miscible liquids, Critical solution temperature and applications. Distribution law, its limitations and applications
Unit II
States of Matter and properties of matter:State of matter, changes in the state of matter, latent heats, vapour pressure, sublimation critical point, eutectic mixtures, gases, aerosols – inhalers, relative humidity, liquid complexes, liquid crystals, glassy states, solid-crystalline, amorphous & polymorphism.
Physicochemical properties of drug molecules: Refractive index, optical rotation, dielectric constant, dipole moment, dissociation constant, determinations and applications
Unit III
Surface and interfacial phenomenon: Liquid interface, surface & interfacial tensions surface free energy, measurement of surface & interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB Scale, solubilisation, detergency, adsorption at solid interface.
Unit IV
Complexation and protein binding: Introduction, Classification of Complexation, Applications, methods of analysis, protein binding, Complexation and drug action, crystalline structures of complexes and thermodynamic treatment of stability constants.
Unit V
pH, buffers and Isotonic solutions: Sorensen’s pH scale, pH determination (electrometric and calorimetric), applications of buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems, buffered isotonic solutions.
Recommended Books
1. Physical Pharmacy by Alfred Martin
2. Experimental Pharmaceutics by Eugene, Parott.
3. Tutorial Pharmacy by Cooper and Gunn.
4. Stocklosam J. Pharmaceutical Calculations, Lea &Febiger, Philadelphia.
5. Liberman H.A, Lachman C., Pharmaceutical Dosage forms, Tablets, Volume-1 to
3, MarcelDekkar Inc.
6. Liberman H.A, Lachman C, Pharmaceutical Dosage forms. Disperse
systems, volume 1, 2, 3. Marcel Dekkar Inc.
7. Physical Pharmaceutics by Ramasamy C and ManavalanR.
8. LaboratoryManual of Physical Pharmaceutics, C.V.S. Subramanyam, J.
Thimma settee
9. Physical Pharmaceutics by C.V.S. Subramanyam
10. Test book of Physical Phramacy, by Gaurav Jain & Roop K. Khar
Solubility of drugs: Introduction
Solubility expressions
Diffusion principles in biological systems
Clinical relevence of solubility
Henry's law solubility of gas in liquid
Solubility of liquids in liquids, (Binary solutions, ideal solutions)
Critical solution temperature and applications
State of matter introduction
Chemical Interactions in states of matter
Chemical Interactions in states of matter
Interactions in states of mater
Interactions in states of mater
Solid state, Crystalline, amorphous, polymorphism
Solid state, Crystalline, amorphous, polymorphism
Liquid State, Boiling, Heat of Vaporization & critical temperature
Liquid State, Boiling, Heat of Vaporization & critical temperature
latent heats, vapour pressure
Eutectic mixtures
Gases, Ideal Gas, Sublimation/ Liquefaction, Aerosols–inhalers, relative humidity
Sublimation/ Liquefaction
Aerosols–inhalers
Relative humidity
Dielectric constant
Dipole dipole interaction, refractive index
Determination of of Physicochemical properties of drug molecules
Applications of Physicochemical properties of drug molecules
Surface & interfacial tensions
Surface free energy
Measurement of Surface and interfacial tension
Spreading coefficient
Spreading coefficient, adsorption at liquid interfaces
Surface active agents
Solubilisation, detergency
Introduction, Classification of Complexation
Applications of Complexation
Crystalline structures of complexes and thermodynamic treatment of stability constants
Buffer equation, buffer capacity
Buffers in pharmaceutical and biological systems
Dr. Rasmita Dash holds a Master of Pharmacy (M.Pharm) and a Doctor of Philosophy (Ph.D.) in Pharmaceutical Sciences. Her academic and research pursuits are centered around innovative approaches in drug delivery and design. With a strong foundation in pharmaceutics, her core areas of expertise include Novel Drug Delivery Systems (NDDS), Nanoparticulate Drug Delivery Systems, and […]