Pharmaceutical Microbiology

Teacher

Dr. Soumya Jal

Category

Core Courses

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Course Name : Pharmaceutical Microbiology

Code(Credit) : CUTM1739 (3-1-0)

Course Objectives

  • Understanding of types & synthesis of antimicrobial agents
  • Manufacture of antibiotics
  • To understand the mechanism of action of antibiotics
  • To study how microorganisms are known to develop resistance to antibiotics

Learning Outcomes

  • With the completion of the course, the students will acquire detailed knowledge of antimicrobial agents, their mechanism of action and basis of resistance of microbes to these antimicrobials, formulations.
  • They will develop an understanding of different types of disinfectants/antiseptics and their uses, evaluation of their bactericidal and bacteriostatic action.
  • The conceptual understanding of the subject provides opportunities for employbility and scopes for higher education.

Course Syllabus

Module 1

Pharmaceutical Microbiology: Chemical disinfectants, Antiseptic, Antibiotics, static and cidal activity. Types of Antibiotics. Synthetic Antimicrobial Agents, Antifungal drug, Antiviral drug.

 

Module 2

Manufacture of Antibiotics: Production of penicillin, Production of Streptomycin.

Assessment of New Antibiotics: Parameters for determination of the usefulness of antibiotics (in vitro and in vivo).

Pharmacokinetics and Pharmacodynamics of Antimicrobial agents.

Antibiotic Assay: Microbiological methods: Disc diffusion technique, Dilution technique.

Microbial Spoilage and Preservation of Pharmaceutical Products.

 

Module 3

Mechanisms of Action of Antibiotics: Cell wall synthesis inhibitors, Inhibitors of protein biosynthesis, Inhibitors of tetrahydrofolate, Disorganize the cytoplasm membrane. Mode of action of Antibiotics (Cell wall synthesis inhibitors, Inhibitors of protein biosynthesis, Inhibitors of tetrahydrofolate, Disorganize the cytoplasm membrane). Bacterial Resistance to Antibiotics. Biochemical mechanisms of resistance, Genetic basis of antibiotic resistance. Problems in antibiotic therapy due to resistance.

 

Suggested Readings:

  1. W B Hugo and A D Russel, Pharmaceutical Microbiology, 2nd Edition

(e-Book link: https://www.pdfdrive.com/hugo-and-russells-pharmaceutical-microbiology-e34745384.html )

  1. T H Sandal Pharmaceutical Microbiology: Essentials for quality assurance and quality control. Woodhead Publishing Series.

(e-Book link: https://www.pdfdrive.com/pharmaceutical-microbiology-essentials-for-quality-assurance-and-quality-control-e157918748.html )

  1. Willey MJ, Sherwood LM & Woolverton C J. (2013). Prescott, Harley and Klein’s Microbiology. 7thEd., McGraw Hill.

(e-Book link: https://www.pdfdrive.com/prescott-harley-and-kleins-microbiology-7th-ed-e188166539.html )

 

Online tutorial links:

  1. Lecturio link

(https://app.lecturio.com/#/course/s/6956 )

 

Simulation links for labs:

All the practice components can be performed by simulation as well as virtual labs.

Amrita Vlab (https://www.youtube.com/channel/UC1ouqR_dIY_WPDPSZo0e8Wg).

labsforlife (http://labsforlife.in/)

Online Source: Lecturio, Udemy, Coursera, article library, NCBI, Study.com, You tube, unacademy, academia

Session 2

Session 3

Topic: Antibiotics

Video on Antibiotics

https://www.youtube.com/watch?v=k8xat-XzgEA

Slideshare link to Antibiotics

https://www.slideshare.net/phmosarrof/presentation-on-antibiotics

Session 4

Topic: static and cidal activity

Video on static and cidal activity

https://www.youtube.com/watch?v=JZtHTwG5otA

Session 5

Topic: Types of Antibiotics

Video on Types of Antibiotics

https://www.youtube.com/watch?v=4yX-aH6dF88

https://www.youtube.com/watch?v=NGwP471sehI

Session 6

Topic: Synthetic Antimicrobial Agents

Video on Synthetic Antimicrobial Agents

https://www.youtube.com/watch?v=k8xat-XzgEA

Slideshare link to Antimicrobial Agents

https://www.slideshare.net/minhazahmed21/min-antibac

https://www.slideshare.net/ShariqHabib/antimicrobial-agents-79357537

Session 7

Session 8

Session 9

Session 10

Session 11

Practice session

Topic: Isolation of human pathogens in sterile condition

Video on Isolation of human pathogens in sterile condition

https://www.youtube.com/watch?v=949qQtAnjIc

http://labsforlife.in/InstructionalVideo.aspx

Procedure to perform Isolation of human pathogens in sterile condition

https://www.researchgate.net/publication/329504511_ISOLATION_AND_IDENTIFICATION_OF_PATHOGENIC_BACTERIA_FROM_COLLEGE_PREMISES

Session 12

Session 13

Topic: Assessment of New Antibiotics

Video on Assessment of New Antibiotics

https://www.youtube.com/watch?v=3szZFDDAHtk

Session 14

Topic: Parameters for determination of the usefulness of antibiotics (in vitro and in vivo)

Video on Parameters for determination of the usefulness of antibiotics

https://www.youtube.com/watch?v=3szZFDDAHtk

Session 15

Session 16

Topic: Pharmacodynamics of Antimicrobial agents

Video on Pharmacodynamics of Antimicrobial agents

https://www.youtube.com/watch?v=01WrflemxK0

https://www.youtube.com/watch?v=tobx537kFaI

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675903/

Slideshare link to Pharmacodynamics of Antimicrobial agents

https://www.slideshare.net/hwrain/pharmacodynamics-of-antibiotics

Session 17

Topic: Antibiotic Assay: Microbiological methods

Video on Antibiotic Assay: Microbiological methods

https://www.youtube.com/watch?v=sx1uDYSfINA

Slideshare link to Antibiotic Assay: Microbiological methods

https://www.slideshare.net/SonamkzBhutia/microbiological-assay-186636779

Session 18

Session 19

Topic: Dilution technique

Video on Dilution technique

https://www.youtube.com/watch?v=bv3rgkNEL7o

Session 20

Topic: Microbial Spoilage of Pharmaceutical Products

Video on Microbial Spoilage of Pharmaceutical Products

https://www.youtube.com/watch?v=DtHj396-3rI

https://www.youtube.com/watch?v=YIvXn-JInmc

https://www.youtube.com/watch?v=easKaFoVhLs

Slideshare link to Microbial Spoilage of Pharmaceutical Products

https://www.slideshare.net/SonamkzBhutia/pharmaceutical-spoilage

https://www.slideshare.net/9034377/spoilage-pharmacy

Session 21

Topic: Preservation of Pharmaceutical Products

Video on Preservation of Pharmaceutical Products

https://www.youtube.com/watch?v=I_1jNtkVWH4

Slideshare link to Preservation of Pharmaceutical Products

https://www.slideshare.net/SonamkzBhutia/preservation-of-pharmaceutical-products-191653694

https://www.slideshare.net/SoniaNazir/pharmaceutical-preservatives

Session 22

Practice session

Topic: Disc Test for Bacteriostatic and Bactericidal activity

Video on Disc Test for Bacteriostatic and Bactericidal activity

https://www.youtube.com/watch?v=sx1uDYSfINA&t=28s

https://www.youtube.com/watch?v=BXr_kcki4Ag&t=11s

Procedure to perform Disc Test for Bacteriostatic and Bactericidal activity

https://courses.lumenlearning.com/microbiology/chapter/testing-the-effectiveness-of-antimicrobials/

Session 23

Practice session

Topic: Dilution Test for Bacteriostatic and Bactericidal activity

Video on Dilution Test for Bacteriostatic and Bactericidal activity

https://www.youtube.com/watch?v=XhyMUHVbrlI

Procedure to perform Dilution Test for Bacteriostatic and Bactericidal activity

https://courses.lumenlearning.com/microbiology/chapter/testing-the-effectiveness-of-antimicrobials/

Session 24

Topic: Mode of action of Antibiotics on cell wall

Video on Mode of action of Antibiotics on cell wall

https://app.lecturio.com/#/lecture/s/6956/23490

https://www.youtube.com/watch?v=IVBCrzjOl40

https://www.youtube.com/watch?v=NGwP471sehI

Slideshare link to Mode of action of Antibiotics on cell wall

https://www.slideshare.net/YazanKherallah/antibiotic-mechanisms-of-action

Session 25

Topic: Mode of action of Antibiotic on cytoplasmic membrane

Video on Mode of action of Antibiotic on cytoplasmic membrane

https://www.youtube.com/watch?v=IVBCrzjOl40

https://www.youtube.com/watch?v=mMk6VWVpRpo&t=9s

Slideshare link to Mode of action of Antibiotic on cytoplasmic membrane

https://www.slideshare.net/YazanKherallah/antibiotic-mechanisms-of-action

Session 26

Topic: Mode of action of Antibiotic on cytoplasm

Video on Mode of action of Antibiotic on cytoplasm

https://www.youtube.com/watch?v=IVBCrzjOl40

Slideshare link to Mode of action of Antibiotic on cytoplasm

https://www.slideshare.net/blackbold14/antibiotics-mechanisms-of-actions

Session 27

Topic: Mode of action of Antibiotics on cell compounds

Video on Mode of action of Antibiotics on cell compounds

https://app.lecturio.com/#/lecture/s/6956/23504

Slideshare link to Mode of action of Antibiotics on cell compounds

https://www.youtube.com/watch?v=5HQmvQJWzNY

http://Video on Mode of action of Antibiotic on cytoplasm

Session 28

Topic: Bacterial Resistance to Antibiotics

Video on Bacterial Resistance to Antibiotics

https://www.youtube.com/watch?v=057phDG4mKU&t=12s

https://www.youtube.com/watch?v=057phDG4mKU&t=7s

https://www.youtube.com/watch?v=mMk6VWVpRpo&t=4s

Slideshare link to Bacterial Resistance to Antibiotics

https://www.slideshare.net/nasertadvi/antibiotic-resistance-14709382

Session 29

Topic: Biochemical mechanisms of resistance

Video on Biochemical mechanisms of resistance

https://www.youtube.com/watch?v=057phDG4mKU&t=12s

Slideshare link to Biochemical mechanisms of resistance

https://www.slideshare.net/amerali6/antimicrobial-resistance-amr-187806112

Session 30

Topic: Genetic basis of antibiotic resistance

Video on Genetic basis of antibiotic resistance

https://www.youtube.com/watch?v=n6MhidjYpww

Session 31

Topic: Problems in antibiotic therapy due to resistance

Video on Problems in antibiotic therapy due to resistance

https://www.youtube.com/watch?v=n6MhidjYpww

Session 32

Practice session

Topic: Screening of herbal plants for Antibiotic activity

Video on Screening of herbal plants for Antibiotic activity

https://www.youtube.com/watch?v=hejV-wmuZio

https://www.youtube.com/watch?v=HpIuwQHGoDI

Procedure to perform Screening of herbal plants for Antibiotic activity

https://www.researchgate.net/publication/235924345_Screening_of_antibacterial_activity_of_medicinal_plants

Session 33

Practice session

Topic: Sterility testing of pharmaceuticals

Procedure to perform Sterility testing of pharmaceuticals

https://gibraltarlabsinc.com/services/microbiology/sterility-testing/

https://www.pharmaguideline.com/2011/11/sop-for-procedure-for-sterility-testing.html#gsc.tab=0

Session 34

Practice session

Topic: Bacteriological analysis of water

Video on Bacteriological analysis of water

https://www.youtube.com/watch?v=LpDjGCsmxZI

Procedure to perform Bacteriological analysis of water

https://www.researchgate.net/publication/330401314_Bacteriological_water_analysis

https://www.who.int/water_sanitation_health/resourcesquality/wqmchap10.pdf

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Dr. Soumya Jal

Associate Professor
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Dr. Soumya Jal is working at Centurion University of Technology and Management since 2018, prior to which she was associated with Rama Devi Women’s University as a visiting faculty.  She has completed her Ph. D. in Medical Biotechnology from VIT University, Vellore (2016). Her research area includes fields such as, Applied and Clinical Microbiology, Molecular […]