COURSE NAME- MOLECULAR PHARMACOKINETICS9NANOTECHNOLOGY AND TARGETED DDS)
COURSE CODE-MPH201T(4-0-0)
COURSE OUTCOME
This course is designed to impart knowledge on the area of advances in novel
drug delivery systems.
COURSE OBJECTIVE
Upon completion of the course student shall be able to understand
- The various approaches for development of novel drug delivery
systems.
- The criteria for selection of drugs and polymers for the development of
NTDS
- The formulation and evaluation of novel drug delivery systems.
SYLLABUS
MODULE-I
Targeted Drug Delivery Systems:
Concepts, Events and biological process involved in drug targeting. Tumor targeting and Brain specific delivery.
MODULE-II
Targeting Methods:
Introduction preparation and evaluation. Nano Particles & Liposomes: Types, preparation and evaluation.
MODULE-III
Micro Capsules / Micro Spheres: Types, preparation and evaluation , Monoclonal Antibodies ; preparation and application, preparation and application of Niosomes, Aquasomes, Phytosomes, Electrosomes.
MODULE-IV
Pulmonary Drug Delivery Systems : Aerosols, propellents, ContainersTypes, preparation and evaluation, Intra Nasal Route Delivery systems; Types, preparation and evaluation.
MODULE-V
Nucleic acid based therapeutic delivery system : Gene therapy, introduction (ex-vivo & in-vivo gene therapy). Potential target diseases for gene therapy (inherited disorder and cancer). Gene expression systems (viral and nonviral gene transfer). Liposomal gene delivery systems. Biodistribution and Pharmacokinetics. knowledge of therapeutic antisense molecules and aptamers as drugs of future.
REFERENCES
- Y W. Chien, Novel Drug Delivery Systems, 2nd edition, revised and expanded,Marcel Dekker, Inc., New York, 1992.
- S.P.Vyas and R.K.Khar, Controlled Drug Delivery - concepts and advances, VallabhPrakashan, New Delhi, First edition 2002.
- N.K. Jain, Controlled and Novel Drug Delivery, CBS Publishers & Distributors, NewDelhi, First edition 1997 (reprint in 2001).
SESSION PLAN
SESSION-01
Targeted Drug Delivery System: Concepts
Session-02
Events and Biological Processes involved in Targeted DDS
Session-03
Tumor Targeting and Brain Specific Drug Delivery
Session-04
Session-05
Session-06
Session-07
Session-08
Session-09
Microcapsules and Microspheres
Session-10
Monoclonal Antibodies
Session-11
Aquasomes: Introduction, Methods of Preparation, Applications
Session-12
Phytosomes:Introduction, Methods of Preparation, Applications
Session-13
Phytosomes: Introduction, Methods of Preparation, Applications
Session-14
Electrosomes: Introduction, Methods of Preparation, Applications
Session-15
Pulomonary Drug Delivery System: Introduction
Session-16
Aerosols: Propellents, Container: Types, Preparation and Evaluation
Session-17
Gene Expression System: Viral and Non-Viral Gene Transfer
Session-18
Nucleic Acid Based Drug Therapeutic System
Session-19
Liposomal Gene Delivery System
Session-20
Session-21