Biopolymer and Hydrogel

Teacher

Dr. Niladri Sarkar

Category

Core Courses

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Course Name : Biopolymer and Hydrogel

Code(Credit) : CUTM 1421(3-1-0)

Course Objectives

  • To introduce students to various classes of biomaterials
  • To develop understanding regarding the characteristics of the materials to be used as biomaterials
  • To develop the understanding regarding the various applications of biomaterials.

Learning Outcomes

  • Students will get introduced to different classes of biomaterials and their applications
  • The vast applications of biomaterials will encourage students to explore them in detail and to design and engineer synthetic and natural materials for biomedical applications
  • The course would also enable the students to appreciate the role of tissue engineering as a tool to enhance the quality of life

Course Syllabus

Module-I (Fundamentals of biopolymers)

  • Definition of biopolymers and types of biopolymers
  • Definition of bioplastics and types of bioplastics.
  • Description of certain biopolymers like starch, cellulose, chitosan, gelatin, alginate, keratin, fatty acids, lipids, aliphatic polyesters (PLA, PHB).
  • Cellulose derivatives and cellulose regenerating processes
  • Bio based composites from Soybean oil and Chicken feathers
  • Preparation of cellulose nanocrystals from raw cellulose (Practice)

Module-II (Polymer biodegradation and biocomposites)

  • Natural biodegradable polymer, synthetic biodegradable polymer and modified naturally biodegradable polymer
  • Testing methods of biodegradability [polymer-Enzyme assays, Plate test, Respiratory test, Gas evolution test (CO2 & CH4)]
  • Use of biopolymers in composite and bioplastic formation and their application in packaging and medical industries
  • Investigation of rate of biodegradation of any sample (biopolymer) through anerobic condition (Practice)

Module-III (Basics of biomaterials)

  • Concept of biocompatibility and responsiveness
  • Technically important form of polymers (Hydrogel, bioceramics, bioelastomers and membranes)
  • Mechanical  properties (elasticity, yield stress, ductility, toughness, strength, fatigue, hardness and wear resistance)  of biomaterials.
  •  Polymers used as biomaterials (Silicon rubber, Dacron, poly(methyl methacrylate, polyurethane and cellulose) and their application
  • Preparation of peptide hydrogel (Practice)

Module-IV (Surface modification and characterization of biomaterials)

  • Surface modification by the use of Corona discharge and plasma processes.
  • Surface modification with polymer coatings
  • Bulk analysis methods applied to the study of Biomaterials (XRD, FTIR, DSC, TGA etc)
  • Surface analysis methods applied to the study of biomaterials (SEM, AFM, etc.)

Module-V (Synthesis and Characterization of hydrogels)

  • Introduction to hydrogel and brief historical overview
  • Classification of hydrogels based on origin, type of interaction, and ionic/non-ionic characteristics
  • Different types of gel forming techniques (Physically and chemically cross-linked hydrogels)
  • Characterization of hydrogel by SEM, FTIR, 13-C NMR and BET/mercury porosimetry
  • Preparation of thermo-reversible agarose hydrogel for gel electrophoresis technique (Practice)

Module-VI (Properties of Hydrogels)

  • Evaluation of swelling behaviors of hydrogels (Swelling capacity and water retention capacity) and kinetic analysis.
  • Effect of pH, ionic strength and temperature on swelling properties of hydrogels
  • Relationship between morphology and swelling properties
  • Mechanical and rheological properties of hydrogel
  • Mechanical properties of interpenetrating (IPN) and multi-networking hydrogel
  • Shear rheometric test on polyacrylamide hydrogel (Practice)

Module-VII (Applications of Hydrogels)

  • Introduction to hydrogel drug delivery systems,
  • Targeted drug delivery and controlled delivery systems (pH responsive and glucose responsive delivery)
  •  Kinetics of Drug Diffusion through hydrogels
  • Hydrogels for bone replacement, artificial organs, dental applications
  • Hydrogel in agricultural application (controlled delivery of water and micronutrients)
  • Drug delivery via hydrogel beads (practice)

Session Plan

Session 1

Definition of biopolymers and types of biopolymers

Youtube-Biopolymer

Reference link

biopolymers and its classification (NPTEL-Youtube)

Session 2

Definition of bioplastics and types of bioplastics

Youtube-Bioplastics

Reference link

bioplastics and biopolymer (Udemy)

Session 3

Description of certain biopolymers like starch, cellulose, chitosan, gelatin, alginate, keratin, fatty acids, lipids, aliphatic polyesters (PLA, PHB)

Starch

Cellulose

Chitosan

Gelatin

Gelation of sodium alginate

keratin protein

Fatty acid

lipids

last part-aliphatic polyesters

Session 4

Cellulose derivatives and cellulose regenerating processes

regenerated fibres

Article on regenerated cellulose

Session 5

Bio based composites from Soybean oil and Chicken feathers

Youtube-chicken feather based adsorbent

Article

Session 6 (Practice-1) 2h

Preparation of cellulose nanocrystals from raw cellulose

Article1

Youtube

Session 7

Natural biodegradable polymer, synthetic biodegradable polymer and modified naturally biodegradable polymer

Biodegradability Youtube

Biodegradable plastics

Reference link

Biomaterials with polymer (MIT)

Session 8

Testing methods of biodegradability [polymer-Enzyme assays, Plate test, Respiratory test, Gas evolution test (CO2 & CH4)]

Google book

degradation of Cellulose and lignin

Reference link

Article

Session 9

Use of biopolymers in composite and bioplastic formation and their application in packaging and medical industries

Article1

Article2

polymers in medicines

Session 10 (Practice 2) 2h

Investigation of rate of biodegradation of any sample (biopolymer) through anerobic condition

https://www.youtube.com/watch?v=Y_zFPkbrwSY&t=130s

Session 11

Concept of biocompatibility and responsiveness

Introduction to biomaterials

Biocompatibility

Responsiveness

Session 12

Technically important form of polymers (Hydrogel, bioceramics, bioelastomers and membranes)

Hydrogel

Bioceramics

Article-Bioelastomer

Session 13

Mechanical  properties (elasticity, yield stress, ductility, toughness, strength, fatigue, hardness and wear resistance)  of biomaterials

mechanical properties

Session 14

Polymers used as biomaterials (Silicon rubber, Dacron, poly(methyl methacrylate, polyurethane and cellulose) and their application

Silicon Rubber

PMMA

Polyurethane

Dacron

Session 15 (Practice 3) (2h)

Preparation of peptide hydrogel

Youtube

Session 16

Surface modification by the use of Corona discharge and plasma processes

Surface modification

plasma treatment

Corona discharge technique-Article

Session 17

Surface modification with polymer coatings

polymer coating

Session 18

Bulk analysis methods applied to the study of Biomaterials (XRD, FTIR, DSC, TGA etc)

XRD analysis

FTIR

DSC-TGA

Session 19

Surface analysis methods applied to the study of biomaterials (SEM,  AFM, etc.)

Youtube-SEM principle

Youtube-AFM

Reference links

SEM-AFM

Session 20

Introduction to hydrogel and brief historical overview

Hydrogel

Session 21

Classification of hydrogels based on origin, type of interaction, and ionic/non-ionic characteristics

Slide share

Reference Link

MIT.edu

Session 22

Different types of gel forming techniques (Physically and chemically cross-linked hydrogels

Article

Session 24 ( Practice 4) (2h)

Preparation of thermo-reversible agarose hydrogel for gel electrophoresis technique

Part I: Gel preparation

Part II: Gel casting

Session 25

Evaluation of swelling behaviors of hydrogels (Swelling capacity and water retention capacity)

Hydrogel Swelling

Gelation and Swelling network of polymers

Session 26

Kinetic analysis of Swelling behaviors

Swelling kinetics

Session 27

Kinetic analysis of Swelling behaviors

Swelling kinetics

MIT.Edu document

Session 28

Effect of pH, ionic strength and temperature on swelling properties of hydrogels

Article1

Article2

Session 29

Relationship between morphology and swelling properties

Article1

Article2

Article3

Session 30

Mechanical and rheological properties of hydrogel

rheology

Session 31 (Practice 5) (2h)

Shear rheometric test on polyacrylamide hydrogel

Youtube

Session 32

Introduction to hydrogel drug delivery systems,Targeted drug delivery and controlled delivery systems (pH responsive and glucose responsive delivery

slideshare PPT

drug delivery

Session 33

Kinetics of Drug Diffusion through hydrogels

Drug delivery principles

Session 34

Hydrogels for bone replacement, artificial organs, dental applications

hydrogel for bone replacement

Article1

Session 35

Hydrogel in agricultural application (controlled delivery of water and micronutrients)

soil and hydrogel

Sodium polyacrylate Chemistry

Article1

Session  36 (Practice 6) (2h)

Drug delivery via hydrogel beads along with selection of phytochemicals to the particular disease via "Discovery studio"/Biovia Software

Youtube

Case Studies

Case Studies

Our Main Teachers

Dr. Niladri Sarkar

Assistant Professor of Chemistry
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Physical Chemistry, Nanoscience and Nanotechnology, Hydrogels