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This course gives total idea about the coordination chemistry and its application towards biological system.
Such knowledge induces advanced knowledge and skills in the field of metal complexes used in biological systems and their behavior. Thus it will aid for getting jobs in biomedical organization
Werner’s theory, Valence bond theory (inner and outer orbital complexes), Electro neutrality principle and back bonding.
Crystal Field Theory
Crystal field theory, measurement of 10 Dq (Δo), CFSE in weak and strong fields, pairing energies, factors affecting the magnitude of 10 Dq (Δo, Δt). Octahedral vs. tetrahedral coordination, tetragonal distortions from octahedral geometry Jahn-Teller theorem, square planar geometry. Qualitative aspect of Ligand field and MO Theory.
To determine the crystal field stabilization energy (CFSE) of metal complexes.(V LAB )
Nomenclature of Coordination Compounds
IUPAC nomenclature of coordination compounds, isomerism in coordination compounds. Stereochemistry of complexes with 4 and 6 coordination numbers. Chelate effect of polynuclear complexes, Labile and inert complexes.
General group trends with special reference to electronic configuration, colour, variable valency, magnetic and catalytic properties, ability to form complexes. Stability of various oxidation states and e.m.f. (Latimer & Bsworth diagrams). Difference between the first, second and third transition series. Chemistry of Ti, V, Cr Mn, Fe and Co in various oxidation states (excluding their metallurgy)
Lanthanoids and Actinoids:
Electronic configuration, oxidation states, colour, Spectral and magnetic properties, lanthanide contraction, separation of lanthanides (ion-exchange method only),Actinides elements and properties
Metal ions present in biological systems, classification of elements according to their action in biological system. Geochemical effect on the distribution of metals. Sodium / K-pump, Carbonic anhydrase and Carboxy peptidase. Excess and deficiency of some trace metals. Toxicity of metal ions (Hg, Pb, Cd and As), Reasons for toxicity, Use of chelating agents in medicine.
Iron and its application in bio-systems, Hemoglobin, Storage and transfer of iron.
Compare graphically the O2 affinity of hemoglobin and myoglobin .
Recommended Books For Practice:
Mendham, J., A. I. Vogel’s Quantitative Chemical Analysis 6th Ed., Pearson, 2009
Valence bond Theory ,Inner and outer orbital complexes
Crystal field theory, measurement of 10 Dq (Δo)
Determination of CFSE in weak and strong fields, pairing energies
Factors affecting the magnitude of 10 Dq (Δo, Δt) in CFT
Qualitative aspect of Molecular Orbital Theory
Isomerism in coordination compounds
Difference between the first, second and third transition series
Chemistry of Ti,V,Cr in various oxidation states (excluding their metallurgy)
Chemistry of Mn,Fe in various oxidation states (excluding their metallurgy)
Lanthanoids:Electronic configuration, oxidation states, colour, spectral and magnetic properties,
Lanthanide Contraction and its consequences
Actinides elements:Electronic configuration, oxidation states, colour, spectral and magnetic properties
Separation Techniques of lanthanides (ion-exchange method only),Difference between lanthanides and Actinides
Sodium / K-pump in Biological System
Geochemical effect on the distribution of metals
Chemistry of Carbonic anhydrase
Chemistry of carboxy peptidase
Notes on Use of chelating agents in medicine.
Hemoglobin and oxygen transport,
Storage and transfer of iron
Graphically compare the O2 affinity of hemoglobin and myoglobin
Iron and its application in bio-systems
Dr. Dojalisa Sahu completed her M.Sc. and M. Phil. degrees from Sambalpur University and joined CSIR-IMMT Bhubaneswar thereafter as a research assistant to peruse a career in research. She got her Ph.D. Degree awarded from Sambalpur University in 2014 and joined Centurion University of Technology and Management (CUTM) as an Assistant Professor in the School […]