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After completion of the course:
Module-I (5 Hrs.)
Nitrogen Containing Functional Groups:Nitro compounds, nitriles and isonitriles
1.1 Structure and Preparation of nitroalkanes and nitroarenes
1.2 Properties and reactions of nitroalkanes
1.3 Properties and reactions of nitroarenes
1.4 Structure, Preparation and properties of nitriles and isonitriles
Assignment 1/Flip class: Important Nitro aromatic compounds and their uses
Module-II (8 Hrs.)
Nitrogen Containing Functional Groups:Amines
2.1 Preparation of primary amines: Reduction of nitro compounds, Hofmann ammonolysis, Hofmann degradation, Gabriel phthalimide synthesis.
2.2 Preparation of secondary and tertiary amines: Aminolysis of alkyl halides, Reductive amination of aldehydes and ketones, Ullmann reaction
2.3 Properties of amines, Basicity, Effect of substituent and solvent on basicity.
2.4 Important reactions of amines: Alkylation, acylation, Carbylamine reaction
2.5 Important reactions of amines: Mannich reaction, Hoffmann’s exhaustive methylation, Hofmann-elimination reaction
2.6 Diazonium Salts: Structure, Preparation and reactions/applications
Assignment 2/Flip class:Electrophilic substitution reactions of aryl amines
Assignment 3/Flip class:Distinction between 1°, 2° and 3°amines with Hinsberg reagent and nitrous acid.
Laboratory Practices (Module I and II): (13.30 hrs.)
1. Detection of extra elements (Nitrogen)
2. Detection of extra elements (Sulphur)
3. Detection of extra elements (Halogens)
4. Functional group test for: Nitro groups
5. Functional group test for: Amine groups
6. Functional group test for: Amide groups
Module-III (8 Hrs.)
Five membered Heterocyclic Compounds containing one heteroatom:
3.1 Classification, nomenclature and structure of pyrrole, furan and thiophene (5-numbered) and pyridine (6-membered)
3.2 Molecular orbital pictures and aromaticity in of pyrrole, furan and thiophene and pyridine
3.3 Synthesis, reactions and mechanism of substitution reactions of: Furan
3.4 Synthesis of Pyrrole: Knorr pyrrole synthesis, Paal-Knorr synthesis, Hantzsch synthesis.
3.5 Reactions and mechanism of substitution reactions of Pyrrole
3.6 Derivatives of furan: Furfural and furoic acid.
Assignment 4/Flip class:Synthesis and Properties of thiophene
Assignment 5/Flip class:Acidic and basic character of Pyrrole, Furan and Thiophene
Module-IV (6 Hrs.)
Six membered and condensed Heterocyclic Compounds:
4.1 Structure, synthesis and properties of Pyridine (Hantzsch synthesis), Pyrimidine
4.2 Structure elucidation of indole, Fischer indole synthesis and Madelung synthesis)
4.3 Structure elucidation of quinoline and isoquinoline
4.4 Skraup synthesis, Friedlander’s synthesis
Assignment 6/Flip class: Knorr quinoline synthesis, Doebner- Miller synthesis
Assignment 7/Flip class:Bischler-Napieralski reaction, Pictet-Spengler reaction, Pomeranz-Fritsch Reaction.
Module-V (5 Hrs.)
Polynuclear Hydrocarbons:
5.1 Preparation and structure elucidation of naphthalene
5.2 Reactions of naphthalene
5.3 Important derivatives of naphthalene
5.4 Preparation, structure elucidation and important derivatives of anthracene.
Assignment 8/Flip class:Preparation, structure elucidation and properties of phenanthrene
Module-VI (6 Hrs.)
Alkaloids
6.1 Natural occurrence, Isolation and their physiological action
6.2 General structural features, experimental determination
6.3 Hoffmann’s exhaustive methylation, Emde’s modification.
6.4 Structure elucidation and synthesis of Hygrine
6.5 Structure elucidation and synthesis of Nicotine.
Assignment 9/Flip class;Medicinal importance of Nicotine, Hygrine, Quinine, Morphine, Cocaine, and Reserpine
Laboratory Practices: (11.30 Hrs.)
7. Qualitative analysis of unknown organic compounds containing simple functional groups: Alcohol
8. Qualitative analysis of unknown organic compounds containing simple functional groups: Carboxylic acids
9. Qualitative analysis of unknown organic compounds containing simple functional groups: Phenols
10. Qualitative analysis of unknown organic compounds containing simple functional groups: Carbonyl compounds (aldehyde)
11. Qualitative analysis of unknown organic compounds containing simple functional groups: (ketones)
Module-VII (3 Hrs.)
Terpenoids:
7.1 Occurrence, classification, isoprene rule;
7.2 Elucidation of structure and synthesis of Citral, Neral
Assignment 10/Flip class:Elucidation of structure and synthesis of α- terpineol.
Text Books :
1. A Textbook of Organic Chemistry – III, M. K. Jain, S. C. Sharma, Amita, Vishal Publishing Co.
2. Kalsi, P. S. Textbook of Organic Chemistry 1st Ed., New Age International (P) Ltd. Pub.
3. Morrison, R. T. & Boyd, R. N. Organic Chemistry, Dorling Kindersley (India) Pvt. Ltd. (Pearson Education)
4. Clayden, J.; Greeves, N.; Warren, S.; Wothers, P.; Organic Chemistry, Oxford University Press.
Reference Books :
1. Acheson, R.M. Introduction to the Chemistry of Heterocyclic compounds, John Welly & Sons (1976).
2. Heterocyclic Chemistry, Fifth Edition, J. A. Joule, K. Mills and G. F. Smith
3. Singh, J.; Ali, S.M. & Singh, J. Natural Product Chemistry, Pragati Parakashan (2010).
Structure and Preparation of nitroalkanes and nitroarenes
http://www.ch.ic.ac.uk/widdowson/teach_files/nitrogen/dw1.html
Properties and reactions of nitroalkanes
https://www.ch.ic.ac.uk/widdowson/teach_files/nitrogen/dw1.html#2
Properties and reactions of nitroarenes
Assignment 1/Flip Class
Application of important nitroarenes
Structure, Preparation and properties of nitriles and isonitriles
Detection of extra elements (Nitrogen containing compound).
lassaigne extract Preparation
https://www.youtube.com/watch?v=foN9ibxBCYU
https://vlab.amrita.edu/?sub=2&brch=191&sim=344&cnt=1
https://www.youtube.com/watch?v=FUo428guKt0
i. Test for Nitrogen
Detection of extra elements.
Test for Halogens
Preparation of primary amines: Reduction of nitro compounds, Hofmann ammonolysis, Hofmann degradation, Gabriel phthalimide synthesis.
Preparation of secondary and tertiary amines: Aminolysis of alkyl halides, Reductive amination of aldehydes and ketones, Ullmann reaction
Properties of amines, Basicity, Effect of substituent and solvent on basicity.
Test for Functional groups.
Test for Nitro group
Important reactions of amines: Alkylation, acylation, Carbylamine reaction.
Important reactions of amines: Mannich reaction, Hoffmann’s exhaustive methylation, Hofmann-elimination reaction
https://www.youtube.com/watch?v=x636_tY0sfY&t=174s
https://www.chemtube3d.com/enolates-with-aldehydes-and-ketones-aldol-reaction-mannich-reaction/
Electrophilic substitution reactions of aryl amines
Test for Functional groups.
Test for Amine group
Distinction between 1°, 2° and 3°amines with Hinsberg reagent and nitrous acid.
https://www.youtube.com/watch?v=j5jgMUWri8U
Reference: https://byjus.com/chemistry/hinsberg-reagent-and-test/
Diazonium Salts: Preparation and their synthetic applications.
http://www.ch.ic.ac.uk/widdowson/teach_files/nitrogen/dw1.html
https://www.youtube.com/watch?v=cNBlYHmW_ok
https://www.youtube.com/watch?v=kFNMB3rY9Ls
https://www.slideserve.com/libitha/diazonium-salts-synthesis
Test for Functional groups.
Test for Amide group
Classification, nomenclature and structure of pyrrole, furan and thiophene (5-numbered) and pyridine (6-membered)
https://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/heterocy.htm
https://www.slideshare.net/AZCPh/heterocyclic-compounds-organic-chemistry-b-pharm
Molecular orbital pictures and aromaticity in of pyrrole, furan and thiophene and pyridine
Synthesis, reactions and mechanism of substitution reactions of: Furan, Paal-Knorr synthesis
https://www.organic-chemistry.org/namedreactions/paal-knorr-furan-synthesis.shtm
https://www.slideshare.net/vayuchaurasiya/furan-presentation
Synthesis of Pyrrole: Knorr pyrrole synthesis, Paal-Knorr synthesis, Hantzsch synthesis.
http://www.chem.gla.ac.uk/staff/stephenc/teaching/HeterocycleLectures2011_2C12.pdf
Reactions and mechanism of substitution reactions of Pyrrole
https://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/heterocy.htm
Synthesis, Properties of thiophene..
http://www.chem.gla.ac.uk/staff/stephenc/teaching/HeterocycleLectures2011_2C12.pdf
Acidic and basic character of Pyrrole, Furan and Thiophene.
http://www.chem.gla.ac.uk/staff/stephenc/teaching/HeterocycleLectures2011_2C12.pdf
href="https://www.saplinglearning.com/media/loudon/loudon5ech25sec03.pdf
Derivatives of furan: Furfural and furoic acid.
http://www.chem.gla.ac.uk/staff/stephenc/teaching/HeterocycleLectures2011_2C12.pdf
Structure, synthesis and properties of Pyridine (Hantzsch synthesis) and Pyrimidine.
http://www.chem.gla.ac.uk/staff/stephenc/teaching/HeterocycleLectures2011_2C12.pdf
Structure elucidation of indole, Fischer indole synthesis and Madelung synthesis .
https://www.youtube.com/watch?v=9DNZS7G-KSM
https://www.youtube.com/watch?v=TW-IleZ0SL0
Lecture_Structure elucidation of indole
Lecture_Indole synthesis
Structure elucidation of quinoline and isoquinoline.
https://www.youtube.com/watch?v=SdKnH7JvRHw
Knorr quinoline synthesis, Doebner- Miller synthesis.
http://repository.sustech.edu/bitstream/handle/123456789/9213/Resaerch.pdf?sequence=3&isAllowed=y
Bischler-Napieralski reaction, Pictet-Spengler reaction, Pomeranz-Fritsch Reaction.
https://en.wikipedia.org/wiki/Bischler%E2%80%93Napieralski_reaction
https://https://en.wikipedia.org/wiki/Pictet%E2%80%93Spengler_reaction
https://https://en.wikipedia.org/wiki/Pomeranz%E2%80%93Fritsch_reaction
Lecture_Isoquinoline synthesis
Reference: https://www.youtube.com/watch?v=nSvnQb_N8js
Preparation and structure elucidation of naphthalene.
Lecture_Naphthalene_Structure and synthesis
Reference: https://www.youtube.com/watch?v=zFyow866BLo
Reactions of naphthalene.
https://www.slideshare.net/ganeshmote1/chemistry-polycyclic-compounds-114408346
Reference: https://www.youtube.com/watch?v=zFyow866BLo
Important derivatives of naphthalene.
https://www.slideshare.net/ganeshmote1/chemistry-polycyclic-compounds-114408346
Lecture_Naphthalene_derivatives
Reference: https://www.youtube.com/watch?v=zFyow866BLo
Preparation, structure elucidation and important derivatives of anthracene.
https://www.slideshare.net/ganeshmote1/chemistry-polycyclic-compounds-114408346
Lecture_Anthracene_Synthesis
Lecture_Anthracene_Reactions
Lecture_Anthracene_Derivatives
Reference: https://www.youtube.com/watch?v=X8NraE_WEvo
Preparation, structure elucidation and properties of phenanthrene.
https://www.youtube.com/watch?v=ZGTJqj21Lw8
https://www.slideshare.net/ganeshmote1/chemistry-polycyclic-compounds-114408346
Natural occurrence, Isolation and physiological action of alkaloids.
https://www.weizmann.ac.il/plants/aharoni/sites/plants.aharoni/files/uploads/june192007.pdf
https://www.youtube.com/watch?v=pON7vnNRx6k
https://www.slideshare.net/priyankagoswami/alkaloids-27405638
General structural features, experimental determination.
Hoffmann’s exhaustive methylation, Emde’s modification.
Qualitative analysis of unknown organic compounds containing simple functional groups.
Analysis of Alcohols
Qualitative analysis of unknown organic compounds containing simple functional groups.
Analysis of Carboxylic acids
Qualitative analysis of unknown organic compounds containing simple functional groups.
Analysis of Phenols
Qualitative analysis of unknown organic compounds containing simple functional groups.
Analysis of Carbonyl Compounds (Aldehydes)
Qualitative analysis of unknown organic compounds containing simple functional groups.
Analysis of Carbonyl Compounds (Ketones)
Structure elucidation and synthesis of Nicotine.
Medicinal importance of Nicotine, Hygrine, Quinine, Morphine, Cocaine, and ReserpineStructure elucidation and synthesis of Nicotine.
https://www.slideshare.net/AhmedMetwaly3/alkaloids-lecture-1-introduction
Terpenoids: Occurrence, classification, isoprene rule.
Elucidation of structure and synthesis of Citral, Neral.
https://www.youtube.com/watch?v=Bo2Z26eOQUo
Elucidation of structure and synthesis of α- terpineol.
Assistant Professor Centurion University of Technology and Management Odisha, India Teaching Organic Chemistry Synthetic methods Stereochemistry Natural products Research areas/interests Synthetic methodology Natural product synthesis Organocatalysis About Me Ph.D in Synthetic organic chemistry from National Chemical Laboratory, Pune Research area: Carbohydrate chemistry, Transition metal catalysis, Methodology and total synthesis. Post-doctoral research: Central […]