NOVEL DRUG DELIVERY SYSTEMS (M Pharm, Industrial Pharmacy)

Teacher

Dr. Rudra Narayan Sahoo

Category

Core Courses

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Course Name : NOVEL DRUG DELIVERY SYSTEMS

Code(Credit) : CUTM2002(4-0-0)

Course Objectives

This course is designed to impart knowledge and skills necessary to train the
students in the area of novel drug delivery systems.

Learning Outcomes

On completion of this course it is expected that students will be able to
understand,
 The need, concept, design and evaluation of various customized,
sustained and controlled release dosage forms.
 To formulate and evaluate various novel drug delivery systems

Course Syllabus

Module-I

       Concept & Models for NDDS: Classification of rate controlled drug delivery systems (DDS), rate programmed release, activation modulated & feedback regulated DDS, effect of system parameters in controlled drug delivery, computation of desired release rate and dose for controlled release DDS, pharmacokinetic design for DDS – intermittent, zero order & first order release.

        Carriers for Drug Delivery: Polymers / co-polymersintroduction, classification, characterization, polymerization techniques, application in CDDS / NDDS, biodegradable & natural polymers.

Module-II

Study of Various DDS: Concepts, design, formulation & evaluation of controlled release oral DDS, Mucoadhesive DDS (buccal, nasal, pulmonary) Pulsatile, colon specific, liquid sustained release systems, Ocular delivery systems.

Module-III

Transdermal Drug Delivery Systems: Theory, design, formulation & evaluation including iontophoresis and other latest developments in skin delivery systems.

Module-IV

Sub Micron Cosmeceuticals: Biology, formulation science and evaluation of various cosmetics for skin, hair, nail, eye etc and it’s regulatory aspects.

Module-V

Targeted Drug Delivery Systems: Importance, concept, biological process and events involved in drug targeting, design, formulation & evaluation, methods in drug targeting – nanoparticles, liposomes, niosomes, pharmacosomes, resealed erythrocytes, microspheres, magnetic microspheres. Specialized pharmaceutical emulsions – multiple emulsions, micro-emulsions.

Module-VI

Protein / Peptide Drug Delivery Systems: Concepts, delivery techniques, formulation, stability testing, causes of protein destabilization, stabilization methods.

Module-VII

Biotechnology in Drug Delivery Systems: Brief review of major areas recombinant DNA technology, monoclonal antibodies, gene therapy.

Module-VIII

New trends for Personalized Medicine: Introduction, Definition, Pharmacogenetics, Categories of Patients for Personalized Medicines: Customized drug delivery systems, Bioelectronic Medicines, 3D printing of pharmaceuticals, Telepharmacy.

Reference Books

1. Novel Drug Delivery System, Y.W. Chein, Vol 50, Marcel Dekker, NY.
2. Controlled Drug Delivery Systems, Robinson, Vol 29, Marcel Dekker, NY.
3. Transdermal Controlled Systemic Medications, YW Chein, Vol 31, Marcel
Dekker, NY.
4. Bioadhesive DDS, E. Mathiowitz, Vol 98, Marcel Dekker, NY.
5. Nasal System Drug Delivery, K.S.E. Su, Vol 39, Marcel Dekker, NY.
6. Drug Delivery Devices, Vol 32, P Tyle Marcel Dekker, NY.
7. Polymers for Controlled Drug Delivery, P.J. Tarcha, CRC Press.
8. Pharmaceutical Biotechnology, Vyas, CBS, Delhi.
9. Biotechnology of Industrial Antibiotics, E.J. Vandamme, Marcel Dekker, NY.
10. Protein Formulation & Delivery, E.J. McNally, Vol 99, Marcel Dekker, NY.
11. Drug Targeting, M.H. Rubinstein, John Wiley, NY.

Session Plan

Session 1

Classification of rate controlled drug delivery systems controlled

https://www.youtube.com/watch?v=4qyzNNA_P7c

Session 2

Session 3

Activation modulated & feedback regulated DDS

https://www.youtube.com/watch?v=4qyzNNA_P7c

Session 4

Effect of system parameters in controlled drug delivery

https://www.youtube.com/watch?v=4qyzNNA_P7c

Session 5

Computation of desired release rate and dose for controlled release DDS

https://www.youtube.com/watch?v=i8CrR-ylV8g

Session 6

Pharmacokinetics design for DDS

https://www.youtube.com/watch?v=8-Qtd6RhfVA

Session 7

Polymers co polymers introduction

https://www.youtube.com/watch?v=EmD0Ex3GiAY

Session 8

Classification and characterization

https://www.youtube.com/watch?v=EmD0Ex3GiAY

Session 9

Session 10

Application of bo degredable polymers

https://www.youtube.com/watch?v=EmD0Ex3GiAY

Session 11

Application of natural polymers

https://www.youtube.com/watch?v=EmD0Ex3GiAY

Session 12

Concept design formulation and evaluation of controlled release oral DDS

https://www.youtube.com/watch?v=KyNvPf2-nNc

Session 13

Concept design formulation and evaluation of controlled release mucoadhesive DDS

https://www.youtube.com/watch?v=KyNvPf2-nNc

Session 14

Concept design formulation and evaluation of controlled release colon specific DDS

https://www.youtube.com/watch?v=KyNvPf2-nNc

Session 15

Concept design formulation and evaluation of controlled release buccal DDS

https://www.youtube.com/watch?v=KyNvPf2-nNc

Session 16

Concept design formulation and evaluation of controlled release nasal DDS

https://www.youtube.com/watch?v=KyNvPf2-nNc

Session 17

Concept design formulation and evaluation of controlled release pulmonary DDS

https://www.youtube.com/watch?v=KyNvPf2-nNc

Session 18

Concept design formulation and evaluation of controlled release liquid sustained release systems DDS.

https://www.youtube.com/watch?v=kQNxETJgBHA

Session 19

Concept design formulation and evaluation of controlled release ocular DDS.

https://www.youtube.com/watch?v=46luf1uwwfE

Session 20

Transdermal drug delivery system

https://www.youtube.com/watch?v=Ilza7nNAjgY

Session 21

Introduction to transdermal drug delivery system

https://www.youtube.com/watch?v=Ilza7nNAjgY

Session 22

Session 23

Evaluation of transdermal DDS

https://www.youtube.com/watch?v=Ilza7nNAjgY

Session 25

Latest develpments in skin delivery system

https://www.youtube.com/watch?v=Ilza7nNAjgY

Session 27

Biology formulation science and evaluation of various cosmetic for skin

https://www.youtube.com/watch?v=i_eOU1wAJdA

Session 28

Biology formulation science and evaluation of various cosmetics for hair

https://www.youtube.com/watch?v=3BQ250d-zYs

Session 29

Biology formulation science and evaluation of various cosmetic for nail

https://www.youtube.com/watch?v=bcCkQ1IiaKA

Session 30

Biology formulation science and evaluation of various cosmetic for eye

https://www.youtube.com/watch?v=bcCkQ1IiaKA

Session 31

Biology formulation science and evaluation of various cosmetic for skin

https://www.youtube.com/watch?v=bcCkQ1IiaKA

Session 32

Session 33

Importnace concept biological process and events involved in drug targeting

Session 34

Design formultion and evaluation methods in drug targeting nanoparticles liposomes niosomes pharmacosomes

Session 35

Specialized pharmaceutical emulsions

Session 36

protein peptide drug delivery systems

Session 37

Biotechnology in drug delivery system

Session 40

3D printing

Session 38

New trends for personalize medicine

Session 39

Bioelectronic medicine

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Case Studies

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