NOVEL DRUG DELIVERY SYSTEMS

Teacher

Dr Gurudutta Pattnaik

Category

Core Courses

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Course Name : NOVEL DRUG DELIVERY SYSTEMS

Code(Credit) : BPHT4104 (4-0-0)

Course Objectives

To impart basic knowledge on the area of novel drug delivery systems.

Learning Outcomes

  • To understand various approaches for development of novel drug delivery systems.
  • To understand the criteria for selection of drugs and polymers for the development of Novel drug delivery systems, their formulation and evaluation.

Course Syllabus

MODULE-I

Controlled drug delivery systems: Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates.Approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and biological properties of drugs relevant to controlled release formulations
Polymers: Introduction, classification, properties, advantages and application of polymers in formulation of controlled release drug delivery systems.

MODULE-II

Microencapsulation: Definition, advantages and disadvantages, microspheres /microcapsules, microparticles, methods of microencapsulation, applications

Mucosal Drug Delivery system: Introduction, Principles of bioadhesion / mucoadhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems

Implantable Drug Delivery Systems:Introduction, advantages and disadvantages, concept of implants and osmotic pump

MODULE-III

Transdermal Drug Delivery Systems: Introduction, Permeation through skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches

Gastroretentive drug delivery systems: Introduction, advantages, disadvantages, approaches for GRDDS – Floating, high density systems, inflatable and gastroadhesive systems and their applications

Nasopulmonary drug delivery system: Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers

MODULE-IV

Targeted drug Delivery: Concepts and approaches advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications

MODULE-V

Ocular Drug Delivery Systems: Introduction, intra ocular barriers and methods to overcome –Preliminary study, ocular formulations and ocuserts

 Intrauterine Drug Delivery Systems: Introduction, advantages and disadvantages, development of intra uterine devices (IUDs) and applications

Session Plan

Session 1

Controlled drug delivery systems: Introduction,  terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates.

PDF- Controlled drug delivery systems_1

Session 2

Approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles.

PDF-Controlled drug delivery systems_2

Session 3

Physicochemical and biological properties of drugs relevant to controlled release formulations

PDF-Physicochemical and biological properties of drugs relevant to controlled release

Session 4

Polymers: Introduction, classification, properties, advantages

PDF-Polymers used in the Designing of Controlled Drug Delivery System

Session 5

Polymers: Application of polymers in formulation of controlled release drug delivery systems.

PDF-POLYMER_A_BOON_TO_CONTROLLED_DRUG_DELIVERY_SYSTEM

Session 6

Microencapsulation: Definition, advantages and disadvantages, microspheres /microcapsules, microparticles

PDF-MICROENCAPSULATION_TECHNIQUES_FACTORS_INFLUENCING_ENCAPSULATION_EFFICIENCY_A_REVIEW

Session 7

Methods of microencapsulation, applications

PPT-MICROENCAPSULATION TECHNIQUES AND APPLICATION

Session 8

Mucosal Drug Delivery system: Introduction, Principles of bioadhesion / mucoadhesion

PPT-Mucoadhesive

Session 9

Mucosal Drug Delivery system: concepts, advantages and disadvantages

PDF-MUCOSAL_DRUG_DELIVERY_SYSTEM

Session 10

Transmucosal permeability and formulation considerations of buccal delivery systems

PDF-Buccal drug Delivery System

Session 11

Implantable Drug Delivery Systems:Introduction, advantages and disadvantages

PDF-Implant

Session 12

Concept of implants

PPT-Implant

Session 14

Transdermal Drug Delivery Systems: Introduction, Permeation through skin, factors affecting permeation.

https://www.slideshare.net/ArshadKhan63/transdermal-drug-delivery-system-119177012

Session 15

Session 17

Gastroretentive drug delivery systems: Introduction, advantages, disadvantages

https://www.slideshare.net/GajananSanap/gastro-retentive-drug-delivery-system

Session 18

Gastroretentive drug delivery systems: Approaches for GRDDS

https://www.slideshare.net/akashaher07/1-gastroretentive-drug-delivery-systems

Session 19

Floating, high density systems, inflatable and gastroadhesive systems and their applications

https://www.slideshare.net/MahendraVishwkarma/inflatable-and-gastroadhesive-systems-in-novel-drug-delivery-systems

Session 20

Nasopulmonary drug delivery system: Introduction to Nasal and Pulmonary routes of drug delivery

https://www.slideshare.net/AmrutaSambrekar/nasal-pulmonary-drug-delivery-system

Session 21

Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers

https://www.slideshare.net/AlexaJacob1/intranasal-drug-delivery-system

Session 22

Targeted drug Delivery: Concepts and approaches advantages and disadvantages.

https://www.slideshare.net/subodhsatishs/targeted-drug-delivery-systems-73312351

Session 23

Introduction to liposomes and their applications

https://www.slideshare.net/DanishKurien/liposomes-9644602

Session 24

Introduction to niosomes and their applications

https://www.slideshare.net/AnilPethe/niosomes-107155223

Session 25

Introduction to nanoparticles and their applications

https://www.slideshare.net/ganapati123/nanoparticle

Session 26

Introduction to monoclonal antibodies and their applications

https://www.slideshare.net/HimalBarakoti/monoclonal-antibodies-130716465

Session 27

Ocular Drug Delivery Systems: Introduction, intra ocular barriers

https://www.slideshare.net/slidenka/ocular-drug-delivary-system

Session 28

Ocular Drug Delivery Systems: Methods to overcome –Preliminary study

https://www.slideshare.net/vijayalakshmikalaga/ocular-drug-delivery-systems

Session 29

Ocular Drug Delivery Systems: Ocular formulations and ocuserts

https://www.slideshare.net/gaurav11288/ocular-drug-delivery-system-ocuserts

Session 30

Intrauterine Drug Delivery Systems: Introduction, advantages and disadvantages

https://www.slideshare.net/PRASHANTDEORE1/intrauterine-intravaginal-drug-delivery-system

Session 31

Intrauterine Drug Delivery Systems: Development of intra uterine devices (IUDs) and applications

https://www.slideshare.net/ManikRajbhandari1/intrauterine-device-iud

Case Studies

Our Main Teachers

Dr Gurudutta Pattnaik

Principal, Professor, SPLS
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Research Interest: Nanoparticle, Liposomal drug delivery, Pharmacokinetics, Pharmaceutical Engineering.