Organometallics and Bioinorganic Chemistry(CUNT2476)(3-0-1)

Teacher

Chittaranjan Routray

Category

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Course objective

  • To have understanding of behavior, structure and bonding of organometallic componds.
  • To understand concepts bioinorganic chemistry.

Course Outcomes

COs Course outcomes Mapping COs with POs (High-3, Medium-2, Low-1)
CO1 Able to gain knowledge on the bonding behaviour and reactions of oranometallic compounds. PO1(3),PO10(2),PO12(2)
CO3 Investigation and Judgements of various bioinorganic activities of  living bodies PO3(3), PO5(2),PO7(2)
CO4 Able to solve different  problems related to structural analysis PO3(2),PO4(3),PO13(3)

 

Module I Organometallic compounds: synthesis, bonding and structure, and reactivity.Transition Metal π- Complexes Transition Metal π- Complexes with unsaturated organic molecules, alkenes, alkynes, allyl, diene, dienyl, arene and trienyl complexes, preparations, properties, nature of bonding and structural features. Important reactions relating to nucleophilic and electrophilic attack on ligands and to organic synthesis. Transition Metal Compounds with Bonds to Hydrogen Transition metal hydrides: Synthesis, properties and reactivity. Transition metal dihydrogen compound: Preparation, properties and reactivity.                                                                                                (4 hours)

Module II: Organometallics in homogeneous catalysis.Coordinative unsaturation, oxidative addition and reductive elimination reactions. Insertion reactions (insertion of CO, SO2 and alkenes). Reactions of coordinated CO in metal carbonyls. Homogenous hydrogenation of alkenes, hydroformylation of alkenes, isomerisation of olefins, Wacker’s process, Zeigler-Natta Polymerization of ethylene, Monsanto acetic acid, Reduction of CO by hydrogen (Fischer-Tropsch reaction).                                                                                         (4 hours)

Module III: Cages and metal clusters, Metal cluster compounds. Preparative methods for metal cluster compounds. Various types of reactions of metal cluster compounds, Cluster of borane and higher boranes compounds.                                                    (4 hours)

Module IV: Analytical chemistry- separation, spectroscopic, electro- and thermoanalytical methods.

Spectroscopic methods Atomic adsorption spectroscopy: Principle and instrumentation, flame atomization, hollow cathode lamps, interference in AAS, applications of AAS in qualitative and quantitative analysis.

Flame photometric methods: Basic principle and instrumentation, applications in quantitative analysis.                                                                                                                       (4 hours)

Module V:Characterisation of inorganic compounds by IR, Raman, UV-vis, NQR, MS, electron spectroscopy and microscopic techniques.

Nuclear Magnetic Resonance contact shifts, factors affecting nuclear relaxation, some applications including biochemical systems, an overview of NMR of metal nuclides EPR: Hyperfine coupling, spin polarization for atoms and transition metal ions, spin-orbit coupling  and applications.

Mossbauer Spectroscopy Basic principles, spectral line shape and natural line width, characteristics of Mossbauer nucleides, Dopplers effect, Applications of Mossbauer Spectroscopy.                                                                                                                                    (6 hours)

Module VI: Bioinorganic chemistry 1:  photosystems,Chlorophylls, photo system I and photo system II in cleavage of water porphyrins, metalloenzymes, metalloenzymes containing magnesium, molybdenum, iron, cobalt, copper and zinc.oxygen transport, oxygen binding,Ion (Na+ and K+ ) transport,  Transport and storage of dioxygen Heme proteins and oxygen uptake, structure and function of hemoglobin, myoglobin, hemocyanins and hemerthrin, model synthetic complexes of iron, cobalt and copper

                                                                                                                        (4 hours)

Module VII: Bioinorganic chemistry 2:Transport and utilization, electron- transfer reactions; nitrogen fixation, Biological nitrogen fixation, molybdenum nitrogenase, spectroscopic and other evidence, other nitrogenases model systems.metal complexes in medicine.     (4 hours)

Project: Students shall have to complete a given project related to the domain topics and submit report.

Session -1

Organometallic compounds: synthesis, bonding and structure, and reactivity.https://www.youtube.com/watch?v=8XF6xWaGxHY

Session-2

Transition Metal π- Complexes Transition Metal π- Complexes with unsaturated organic molecules, alkenes, alkynes, allyl, diene, dienyl, arene and trienyl complexes, preparations, properties, nature of bonding and structural features.

https://www.youtube.com/watch?v=rn_Dx5MztTg

Session-3

Important reactions relating to nucleophilic and electrophilic attack on ligands and to organic synthesis

https://www.youtube.com/watch?v=JJMe67BZsIo

Session-4

Transition Metal Compounds with Bonds to Hydrogen Transition metal hydrides: Synthesis, properties and reactivity. Transition metal dihydrogen compound: Preparation, properties and reactivity

https://www.youtube.com/watch?v=iz7G41YlxTo

Session-5

Organometallics in homogeneous catalysis.Coordinative unsaturation, oxidative addition and reductive elimination reactions

https://www.youtube.com/watch?v=RLM6CzQsT7w

Session-6

Insertion reactions (insertion of CO, SO2 and alkenes). Reactions of coordinated CO in metal carbonyls

https://www.youtube.com/watch?v=XG6PBDgikwI

Session-7

Homogenous hydrogenation of alkenes, hydroformylation of alkenes, isomerisation of olefins, Wacker’s process

https://www.youtube.com/watch?v=Adkfs_Saz7A

Session-8

Zeigler-Natta Polymerization of ethylene, Monsanto acetic acid, Reduction of CO by hydrogen (Fischer-Tropsch reaction).

Monsanto Acetic Acid Process & Cativa Process

Homogeneous Catalysis, Zeigler-Natta Polymerization of Olefins by Bent

Metallocenes

Session-9

Cages and metal clusters, Metal cluster compounds

https://www.youtube.com/watch?v=zUHbH1X2Tvw

Session-10

Preparative methods for metal cluster compounds

https://www.youtube.com/watch?v=mLuyVwDdvy0

Session-11

Various types of reactions of metal cluster compounds

https://www.youtube.com/watch?v=UR5hn73J_Bs

Session-12

Cluster of borane and higher boranes compounds.

https://www.youtube.com/watch?v=-MH_uwkxyAA

Session-13

Analytical chemistry- separation, spectroscopic, electro- and thermoanalytical methods

https://www.youtube.com/watch?v=W_KO3ahVu4s

Analytical Separations

 

Session-14

Spectroscopic methods of analysis

https://www.youtube.com/watch?v=UHa5w6uuF3M

Session-15

Atomic adsorption spectroscopy: Principle and instrumentation, flame atomization, hollow cathode lamps, interference in AAS, applications of AAS in qualitative and quantitative analysis

https://www.youtube.com/watch?v=IkAgtjohqZY

Session-16

Flame photometric methods: Basic principle and instrumentation, applications in quantitative analysis.

https://www.youtube.com/watch?v=70t79Gd3thg

Session-17

Characterization of inorganic compounds by IR, , MS, electron spectroscopy and microscopic techniques.

https://www.youtube.com/watch?v=Vuc25E1eyX0

Session-18

Raman Spectroscopy, UV-VIS Spectroscopy and NQR

UV-VIS Spectroscopy

Raman Spectroscopy

NQR

Session-19

Nuclear Magnetic Resonance contact shifts, factors affecting nuclear relaxation, some applications including biochemical systems, an overview of NMR of metal nuclides

NMR Spectroscopy

Session-20

EPR: Hyperfine coupling, spin polarization for atoms and transition metal ions, spin-orbit coupling  and applications

EPR/ESR Spectroscopy

Session-21

Mossbauer Spectroscopy Basic principles, spectral line shape and natural line width, characteristics of Mossbauer nucleides, Dopplers effect, Applications of Mossbauer Spectroscopy.         

   

https://www.youtube.com/watch?v=KSzZmq68LOo

Session-22

photosystems,Chlorophylls, photo system I and photo system II in cleavage of water porphyrins

https://www.youtube.com/watch?v=NdJpF0RA2R8&t=18s

Session-23

metalloenzymes, metalloenzymes containing magnesium, molybdenum, iron, cobalt, copper and zinc.

https://www.youtube.com/watch?v=cQbpZsaRm8A&t=98s

Session-24

oxygen transport, oxygen binding,Ion (Na+ and K+ ) transport,  Transport and storage of dioxygen Heme proteins and oxygen uptake

https://www.youtube.com/watch?v=sVD74phIv7k

Session-25

structure and function of hemoglobin, myoglobin, hemocyanins and hemerthrin

https://www.youtube.com/watch?v=3wFX9Zk3PaU

Session-26

model synthetic complexes of iron, cobalt and copper

https://www.youtube.com/watch?v=W6jcgxTH-Tg&t=102s

Session-27

Transport and utilization, electron- transfer reactions

https://www.youtube.com/watch?v=vJnzyxxFiVU

Session-28

nitrogen fixation, Biological nitrogen fixation

https://www.youtube.com/watch?v=Xsjr7ZJt11A

Session-29

molybdenum nitrogenase, spectroscopic and other evidence

molybdenum nitrogenase

Spectroscopic and other evidence

Session-30

other nitrogenases model systems. metal complexes in medicine

other nitrogenases model systems

metal complexes in medicine

Our Main Teachers

Mr. Chittaranjan Routray, M.Sc ,Ph.D(Cont…) serving as Assistant Professor in the Department of Chemistry,School of Applied Sciences of Centurion University of Technology and Management, Odisha. He has more than 12 years of Experiences as an Academician as well as Researcher.  His subject of expertise includes Polymer Chemistry, Spectroscopy, Nano Technology, Water Technology and Bio Chemistry […]