Pharmaceutical Analysis Practical- I

Teacher

Dr. BIKASH RANJAN JENA, M.Pharm., Ph.D

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Course Code: [CUTM2428]

Course Type: Core

Course Objectives

After completion of course student is able to know,
 Chemicals and Excipients
 The analysis of various drugs in single and combination dosage forms
 Theoretical and practical skills of the instrument

Scope

This subject deals with various advanced analytical instrumental techniques for
identification, characterization and quantification of drugs. Instruments dealt are
NMR, Mass spectrometer, IR, HPLC, GC etc.

Course Outcome:

CO Statement Mapping with POs
CO-1 Understand the interaction of matter with electromagnetic radiations and its applications in drug analysis  PO1, PO2, PO8
CO-2 Understand the chromatographic separation and analysis of drugs. PO1, PO6, PO9
CO-3 Perform quantitative & qualitative analysis of drugs using various analytical instruments. PO1, PO2, PO8
CO-4 Able to separate and analyses drugs by chromatography Radioimmunoassay and Electrophoresis PO1, PO3, PO6, PO8
CO-5 student interpretation skills will be improve by the course content in terms of choice of analytical techniques to perform the estimation of different category drugs. PO1, PO2, PO6

SYLLABUS

  1. Analysis of Pharmacopoeial compounds and their formulations by UV Vis spectrophotometer
  2. Simultaneous estimation of multi component containing formulations by UV spectrophotometry.
  1. Experiments based on HPLC
  2. Experiments based on Gas Chromatography
  3. Estimation of riboflavin/quinine sulphate by fluorimetry
  4. Estimation of sodium/potassium by flame photometry
  5. Assay of official compounds by different titrations
  6. Assay of official compounds by instrumental techniques.
  7. Quantitative determination of hydroxyl group.
  8. Quantitative determination of amino group
  9. Colorimetric determination of drugs by using different reagents
  10. Imupurity profiling of drugs
  11. Calibration of glasswares
  12. Calibration of pH meter
  13. Calibration of UV-Visible spectrophotometer
  14. Calibration of FTIR spectrophotometer
  15. Calibration of GC instrument
  16. Calibration of HPLC instrument
  17. Cleaning validation of any one equipment
  18. Determination of total reducing sugar
  19. Determination of proteins
  20. Determination of saponification value, Iodine value, Peroxide value, Acid value in food products
  21. Determination of fat content and rancidity in food products
  22. Analysis of natural and synthetic colors in food
  23. Determination of preservatives in food
  24. Determination of pesticide residue in food products
  25. Analysis of vitamin content in food products
  26. Determination of density and specific gravity of foods
  27. Determination of food additives

Session 1

Simultaneous Estimation of Multicomponent Containing Formulations Using UV Spectrophotometry

Session 2

Estimation of Salicylic Acid by Colorimetric Methods

Session 3

Determination of Maximum Wavelength Of KMNO4

Session 4

Determination Effect of Concentration Of Absorbance Maximum Of  Potasium Permanganate

Session 5

Estimation of riboflavin/quinine sulphate by fluorimetry

Session 6

Estimation of Dextrose In Sample By Colorimetry

Session 7

Separation and Identification of Aminoacids By Paper Chromatography

Session 8

Determination of Pka Value Of Acetic Acid Using Potentiometry

Session 9

Determination of Sulphate limit in Calcium gluconate using Nephlo-Turbidimetry.

Session 10

Determination of saponification value, Iodine value, Acid value in food products

Our Main Teachers

Dr. BIKASH RANJAN JENA, M.Pharm., Ph.D

Associate Professor, M.Pharm., Ph.D.
VIEW PROFILE

About Me My self Dr.Bikash Ranjan Jena currently working in Pharmaceutical Analysis & Research Division, School of Pharmacy and Life Sciences (SoPLS), Centurion University, Bhubaneswar since Jan 2021.  I have successfully awarded my Ph.D  degree at KLEF Deemed to be University, Vaddeswaram, Guntur, A.P on 22nd June 2023. Expertised in Analytical Quality by Design (AQbD), […]