Pharmaceutical Chemistry (D.Pharm)

Teacher

Mr. Satish Kanhar

Category

Core Courses

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Course Code (Credit):

CUTM 2020 (4-0-0)
Course objective
  1. Chemical classification, chemical name, chemical structure
  2. Pharmacological uses, doses, stability and storage conditions
  3. Different types of formulations / dosage form available and their brand names
  4. Impurity testing and basic quality control tests
Learning outcomes
  1. Describe the chemical class, structure and chemical name of the commonly used drugs and pharmaceuticals of both organic and inorganic nature
  2. Discuss the pharmacological uses, dosage regimen, stability issues and storage conditions of all such chemical substances commonly used as drugs
  3. Describe the quantitative and qualitative analysis, impurity testing of the chemical substances given in the official monographs
  4. Identify the dosage form & the brand names of the drugs and pharmaceuticals popular in the marketplace
Course Syllabus
Chapter-1
Introduction to Pharmaceutical chemistry: Scope and objectives
Sources and types of errors: Accuracy, precision, significant figures
Impurities in Pharmaceuticals: Source and effect of impurities in Pharmacopoeial substances, importance of limit test, Principle and procedures of Limit tests for chlorides, sulphates, iron, heavy metals and arsenic.
Chapter-2
Volumetric analysis: Fundamentals of volumetric analysis, Acid-base titration, non-aqueous titration, precipitation titration, complexometric titration, redox titration
Gravimetric analysis: Principle and method.
Chapter-3
  • Haematinics: Ferrous sulphate, Ferrous fumarate, Ferric ammonium citrate, Ferrous ascorbate, Carbonyl iron
  • Gastro-intestinal Agents: Antacids :Aluminium hydroxide gel, Magnesium hydroxide, Magaldrate, Sodium bicarbonate, Calcium Carbonate, Acidifying agents, Adsorbents, Protectives, Cathartics
  • Topical agents: Silver Nitrate, Ionic Silver, Chlorhexidine Gluconate, Hydrogen peroxide, Boric acid, Bleaching powder, Potassium permanganate
  • Dental products: Calcium carbonate, Sodium fluoride, Denture cleaners, Denture adhesives, Mouth washes
  • Medicinal gases: Carbon dioxide, nitrous oxide, oxygen
Chapter-4
Introduction to nomenclature of organic chemical systems with particular reference to heterocyclic compounds containing up to Three rings
Chapter-5
  • Anaesthetics: Thiopental Sodium*, Ketamine Hydrochloride*, Propofol
  • Sedatives and Hypnotics: Diazepam*, Alprazolam*, Nitrazepam, Phenobarbital*
  • Antipsychotics: Chlorpromazine Hydrochloride*, Haloperidol*, Risperidone*, Sulpiride*, Olanzapine, Quetiapine, Lurasidone
  • Anticonvulsants: Phenytoin*, Carbamazepine*, Clonazepam, Valproic Acid*, Gabapentin*, Topiramate, Vigabatrin, Lamotrigine
  • Anti-Depressants: Amitriptyline Hydrochloride*, Imipramine Hydrochloride*, Fluoxetine*, Venlafaxine, Duloxetine, Sertraline, Citalopram, Escitalopram, Fluvoxamine, Paroxetine
Chapter-6
  • Sympathomimetic Agents: Direct Acting: Nor- Epinephrine*, Epinephrine, Phenylephrine, Dopamine*, Terbutaline, Salbutamol (Albuterol), Naphazoline*, Tetrahydrozoline. Indirect Acting Agents: Hydroxy Amphetamine, Pseudoephedrine. Agents With Mixed Mechanism: Ephedrine, Metaraminol
  • Adrenergic Antagonists: Alpha Adrenergic Blockers: Tolazoline, Phentolamine
  • Phenoxybenzamine, Prazosin. Beta Adrenergic Blockers: Propranolol*, Atenolol*, Carvedilol
  • Cholinergic Drugs and Related Agents: Direct Acting Agents: Acetylcholine*, Carbachol, And Pilocarpine. Cholinesterase Inhibitors: Neostigmine*, Edrophonium Chloride, Tacrine Hydrochloride, Pralidoxime Chloride, Echothiopate Iodide
  • Cholinergic Blocking Agents: Atropine Sulphate*, Ipratropium Bromide Synthetic Cholinergic Blocking Agents: Tropicamide, Cyclopentolate Hydrochloride, Clidinium Bromide, Dicyclomine Hydrochloride*
Chapter-7
  • Anti-Arrhythmic Drugs: Quinidine Sulphate, Procainamide Hydrochloride, Verapamil, Phenytoin Sodium*, Lidocaine Hydrochloride, Lorcainide Hydrochloride, Amiodarone and Sotalol
  • Anti-Hypertensive Agents: Propranolol*, Captopril*, Ramipril, Methyldopate Hydrochloride, Clonidine Hydrochloride, Hydralazine Hydrochloride, Nifedipine,
  • Antianginal Agents: Isosorbide Dinitrate
Chapter-8
Diuretics: Acetazolamide, Frusemide*, Bumetanide, Chlorthalidone, Benzthiazide, Metolazone, Xipamide, Spironolactone
Chapter-9
Hypoglycemic Agents: Insulin and Its Preparations, Metformin*, Glibenclamide*, Glimepiride, Pioglitazone, Repaglinide, Gliflozins, Gliptins
Chapter-10
Analgesic And Anti-Inflammatory Agents: Morphine Analogues, Narcotic Antagonists; Nonsteroidal Anti-Inflammatory Agents (NSAIDs) - Aspirin*, Diclofenac, Ibuprofen*, Piroxicam, Celecoxib, Mefenamic Acid, Paracetamol*, Aceclofenac
Chapter-11
  • Antifungal Agents: Amphotericin-B, Griseofulvin, Miconazole, Ketoconazole*, Itraconazole, Fluconazole*, Naftifine Hydrochloride
  • Urinary Tract Anti-Infective Agents: Norfloxacin, Ciprofloxacin, Ofloxacin*, Moxifloxacin,
  • Anti-Tubercular Agents: INH*, Ethambutol, Para Amino Salicylic Acid, Pyrazinamide, Rifampicin, Bedaquiline, Delamanid, Pretomanid*
  • Antiviral Agents: Amantadine Hydrochloride, Idoxuridine, Acyclovir*, Foscarnet, Zidovudine,
Ribavirin, Remdesivir, Favipiravir
  • Antimalarials: Quinine Sulphate, Chloroquine Phosphate*, Primaquine Phosphate, Mefloquine*, Cycloguanil, Pyrimethamine, Artemisinin
  • Sulfonamides: Sulfanilamide, Sulfadiazine, Sulfamethoxazole, Sulfacetamide*, Mafenide Acetate, Cotrimoxazole, Dapsone*
Chapter-12
Antibiotics: Penicillin G, Amoxicillin*, Cloxacillin, Streptomycin, Tetracyclines: Doxycycline, Minocycline, Macrolides: Erythromycin, Azithromycin, Miscellaneous: Chloramphenicol* Clindamycin
Chapter-13
Anti-Neoplastic Agents: Cyclophosphamide*, Busulfan, Mercaptopurine, Fluorouracil*, Methotrexate, Dactinomycin, Doxorubicin Hydrochloride, Vinblastine Sulphate, Cisplatin*, Dromostanolone Propionate
Reference
  1. Text Book of Pharmaceutical Organic Chemistry by Mohammed Ali
  2. Text Book of Medicinal Chemistry by S.N Pandeya
  3. Pharmaceutical Inorganic Chemistry by G.R Chatwal
  4. Text Book of Medicinal Chemistry by Asutosh Kar
  5. Pharmaceutical Analysis by A.V Kasture
Session Plan
Session 1
Introduction to Pharmaceutical chemistry
http://Introduction to Pharmaceutical chemistry
Session 2
Sources and types of errors
http://Sources and types of errors
Session 3
Impurities in Pharmaceuticals
http://Impurities in Pharmaceuticals
Session 4
Volumetric analysis
http://Volumetric analysis
Session 5
Gravimetric analysis
http://Gravimetric analysis
Session 6
Haematinics
http://Haematinics
Session 7
Gastro-intestinal Agents
http://Gastro-intestinal Agents
Session 8
Topical agents
http://Topical agents
Session 9
Dental products
http://Dental products
Session 10
Medicinal gases
http://Medicinal gases
Session 11
Anaesthetics
http://Anaesthetics
Session 12
Sedatives and Hypnotics
http://Sedatives and Hypnotics
Session 13
Antipsychotics
http://Antipsychotics
Session 14
Anticonvulsants
http://Anticonvulsants
Session 15
Anti-Depressants
http://Anti-Depressants
Session 16
Sympathomimetic Agents
http://Sympathomimetic Agents
Session 17
Indirect Acting Agents
http://Indirect Acting Agents
Session 18
Adrenergic Antagonists
http://Adrenergic Antagonists
Session 19
Cholinergic Drugs and Related Agents
http://Cholinergic Drugs and Related Agents
Session 20
Cholinergic Blocking Agents
http://Cholinergic Blocking Agents
Session 21
Synthetic Cholinergic Blocking Agents
http://Synthetic Cholinergic Blocking Agents
Session 22
Anti-Arrhythmic Drugs
http://Anti-Arrhythmic Drugs
Session 23
Anti-Hypertensive Agents
http://Anti-Hypertensive Agents
Session 24
Antianginal Agents
http://Antianginal Agents
Session 25
Diuretics
http://Diuretics
Session 26
Hypoglycemic Agents
http://Hypoglycemic Agents
Session 27
Analgesic And Anti-Inflammatory Agents
http://Analgesic And Anti-Inflammatory Agents
Session 28
Inflammatory Agents (NSAIDs)
http://Inflammatory Agents (NSAIDs)
Session 29
Antifungal Agents
http://Antifungal Agents
Session 30
Urinary Tract Anti-Infective Agents
http://Urinary Tract Anti-Infective Agents
Session 31
Anti-Tubercular Agents
http://Anti-Tubercular Agents
Session 32
Antiviral Agents
http://Antiviral Agents
Session 33
Antimalarials
http://Antimalarials
Session 34
Sulfonamides
http://Sulfonamides
Session 35
Antibiotics
http://Antibiotics
Session 36
Anti-Neoplastic Agents
http://Anti-Neoplastic Agents

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