Pharmaceutical Inorganic Chemistry (Theory)

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Mr. Satish Kanhar

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Core Courses

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Course Name : Pharmaceutical Inorganic Chemistry (Theory)

Code(Credit) : BPHT1104(4-0-0)

Course Objectives

  • This subject has been designed to make the students understand different categories of inorganic drugs or  compounds which are used as medicinal agents.
  • Explanation of the sources of impurities and methods to determine the impurities in inorganic pharmaceuticals
  • Explanation of the method of preparation, assay, properties, medicinal uses of acids, bases, buffers,  extra and intracellular electrolytes.
  • Explanation of the method of preparation, assay, properties, medicinal uses of dental products.
  • Explanation of the method of preparation, assay, properties, medicinal uses of acidifiers, antacids and cathartics.
  • Explanation of  the method of preparation, assay, properties, medicinal uses of antimicrobials
  • Explanation of  the method of preparation, assay, properties, medicinal uses of expectorants, emetics  and haematinics
  • Explanation of  the method of preparation, assay, properties, medicinal uses of astringent, poison  and antidote
  • Description of the properties, storage condition and application of radiopharmaceuticals.

Course Outcomes

CO Statement Mapping with POs
CO-1 Know the sources of impurities and methods to determine the impurities in inorganic drugs and pharmaceuticals PO1, PO2, PO5
CO-2 Understand the medicinal and pharmaceutical importance of inorganic compounds PO1, PO2, PO5
CO-3 Able to compare and analyze different cations and anions. PO1, PO2, PO5
CO-4 Learning different skills to determine percentage purity of different pharmaceuticals. PO1, PO2, PO5
CO-5 Able to classify inorganic pharmaceuticals and can apply them in new therapy. PO1, PO2, PO5

Course Syllabus

MODULE I-

  •  Impurities in pharmaceutical substances: History of Pharmacopoeia, Sources and types of impurities, principle involved in the limit test for Chloride, Sulphate, Iron, Arsenic, Lead and Heavy metals, modified limit test for Chloride and Sulphate
  • General methods of preparation, assay for the compounds superscripted with asterisk (*), properties and medicinal uses of inorganic compounds belonging to the following classes

MODULE II-

  • Acids, Bases and Buffers: Buffer equations and buffer capacity in general, buffers in pharmaceutical systems, preparation, stability, buffered isotonic solutions, measurements of tonicity, calculations and methods of adjusting isotonicity.
  • Major extra and   intracellular   electrolytes:   Functions   of   majorphysiological ions, Electrolytes used in the replacement therapy: Sodium chloride*, Potassium chloride, Calcium gluconate* and Oral Rehydration Salt (ORS), Physiological acid base balance.
  • Dental products: Dentifrices, role of fluoride in the treatment of dental caries, Desensitizing agents, Calcium carbonate, Sodium fluoride, and Zinc eugenol cement.

MODULE III-

  • Gastrointestinal agents-
  1.        Acidifiers: Ammonium chloride* and Dil. HCl
  2.       Antacid:   Ideal properties of antacids, combinations of antacids, Sodium Bicarbonate*, Aluminum hydroxide gel, Magnesium hydroxide mixture
  3.      Cathartics: Magnesium sulphate, Sodium orthophosphate, Kaolin and Bentonite.
  4. Antimicrobials: Mechanism, classification, Potassium permanganate, Boric acid, Hydrogen peroxide*, Chlorinated lime*, Iodine and its preparations

MODULE IV-

  • Miscellaneous compounds
  1. Expectorants: Potassium iodide, Ammonium chloride*.
  2. Emetics: Copper sulphate*, Sodium potassium tartarate
  3. Haematinics: Ferrous sulphate*, Ferrous gluconate
  4. Poison and Antidote: Sodium thiosulphate*, Activated charcoal, Sodium nitrite333
  5. Astringents: Zinc Sulphate, Potash Alum.

MODULE V-

  • Radiopharmaceuticals: Radio activity, Measurement of radioactivity, Properties of α, β, γ radiations, Half life, radio isotopes and study of radio isotopes - Sodium iodide I131, Storage conditions, precautions & pharmaceutical application of radioactive substances.

BOOK REFERENCE-

  1. Anand & Chatwal, Inorganic Pharmaceutical Chemistry
  2. Bentley and Driver's Textbook of Pharmaceutical Chemistry
  3. L Schroff, Inorganic Pharmaceutical Chemistry
  4. Gundu Rao, Inorganic Pharmaceutical Chemistry, 3rd Edition
  5. I. Vogel, Text Book of Quantitative Inorganic analysis
  6. Indian  Pharmacopoeia

 

Session Plan

Session 1

Introduction to pharmaceutical inorganic chemistry and history of pharmacopoeia.

pharmacopoeia-151218070437

http:/www.youtube.com/watch?v=xoXCFe22RWw

Session 2

History of pharmacopoeia

History of Pharmacopoeia

Session 3

Sources and types of impurities in pharmaceutical substances

Sources and types of impurities

INORGANICIMPURITIESimpurities-170129153206

 

Session 8

Acid, base, buffer theories & introduction

acid,base buffer

acid,base buffer

Acid,base buffer

Session 9

Buffers equation, buffer capacity,buffered isotonic solution

bufferedisotonicsolutions-160926181708

Session 10

Buffers in pharmacy,its uses and stability

Role of Buffers in Pharmacy

Criteria for Buffers [Autosaved]

Session 11

Buffered isotonic solutions, measurements of tonicity, calculations and methods of adjusting isotonicity.

buffered isotonic solution

Buffered isotonic solution

Session 14

Session 15

Electrolytes used in the replacement therapy-sodium chloride, potassium chloride

11electrilyteinreplacementthpy-170731061034

Electrolyte replacement therapy

Session 16

Electrolyte combination therapy

electrolytescombinationtherapy-180217082157

Session 17

Session 18

Dental products: Dentifrices, role of fluoride in the treatment of dental caries, Desensitizing agents

DENTRIFICES

Session 19

Calcium carbonate, Sodium fluoride, and Zinc eugenol cement.

Dental products-Calcium carbonate,sodium fluoride

Session 21

Antacid:   Ideal properties of antacids, combinations of antacids

ANTACIDS

gastrointestinalagents-180119061739

Antacids

Session 22

Sodium bicarbonate, aluminium hydroxide gel,magnesium hydroxide mixture

UNIT-III_GastrointestinalagentsAntacid

Session 23

Cathartics: Magnesium sulphate, Sodium orthophosphate, Kaolin and Bentonite

CATHARTICS

Cathartics

Session 24

Antimicrobials: Mechanism, classification

Anti-Microbial agents

Session 25

Anti microbials-Potassium permanganate, Boric acid, Hydrogen peroxide*

UNIT-III_Antimicrobials

Session 26

Anti microbials-Chlorinated lime*, Iodine and its preparations

part IV Antimicrobial agents

Anti microbials

Session 27

Expectorants: Potassium iodide, Ammonium chloride*.

EXPECTORANTS

Expectorants

Session 28

Emetics: Copper sulphate*, Sodium potassium tartarate

Emetics

Session 29

Haematinics: Ferrous sulphate*, Ferrous gluconate

HAEMATINICS-converted (1)

UNIT-IV_Haematinics (1)

Haematinics

Session 30

Poison and Antidote: Sodium thiosulphate*, Activated charcoal, Sodium nitrite333

Poison and Antidotes

antidote-161102141023

antidote for poison

Session 32

Radiopharmaceuticals: Radio activity, Measurement of radioactivity

Radiopharmaceuticals

Radiopharmaceuticals

Session 33

Properties of α, β, γ radiations, Half life, radio isotopes and GM-COUNTER

Geiger Muller Counter

Session 34

Study of radio isotopes  and Sodium iodide I131

UNIT-V_Radiopharmaceuticals

Session 35

Storage conditions, precautions & pharmaceutical application of radioactive substances.

radiopharmaceuticalsrappchapter-8-180817070723

radiopharmaceuticals-180119071848

Case Studies

Case Studies

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Mr. Satish Kanhar

Assistant Professor
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