Pharmaceutical Organic Chemistry-I (Theory)

Teacher

Biswajit Samantaray

Category

Core Courses

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Course Name: Pharmaceutical organic chemistry - I

Code (credit): BPHT1202 (4-0-0)

Course Objectives

This subject deals with classification and nomenclature of simple organic compounds, structural isomerism, intermediates forming in reactions, important physical properties, reactions and methods of preparation of these compounds. The syllabus also emphasizes on mechanisms and orientation of reactions.

Course Outcomes

CO Statements PO MAPPING
CO-1 Able to acquire knowledge about pharmaceutical organic compounds, with emphasis on their synthetic process, physical and chemical properties and compare them with each other PO1, PO2, PO11
CO-2 Able to write mechanisms involved in various reactions that could help the students to understand the synthesis of higher organic compounds. PO1, PO2, PO5, PO11
CO-3 Account for reactivity/stability of compounds, PO1, PO2, PO11
CO-4 Identify/confirm the identification of organic compound PO1, PO2, PO11
CO-5 Able to analyze various reactions for the synthesis of higher organic compounds. PO1, PO2, PO5, PO1

Course Syllabus

MODULE-I 
Classification, nomenclature and isomerism
Classification of Organic Compounds
Common and IUPAC systems of nomenclature of organic compounds (up to 10 Carbons open chain and carbocyclic compounds)
Structural isomerisms in organic compounds
MODULE-II
Alkanes*, Alkenes* and Conjugated dienes*
SP3 hybridization in alkanes, Halogenation of alkanes, uses of paraffins. Stabilities of alkenes, SP2 hybridization in alkenes
E1 and E2 reactions – kinetics, order of reactivity of alkyl halides, rearrangement of carbocations, Saytzeffs orientation and evidences. E1 verses E2 reactions, Factors affecting E1 and E2 reactions. Ozonolysis, electrophilic addition reactions of alkenes, Markownikoff’s orientation, free radical addition reactions of alkenes, Anti Markownikoff’s orientation.
Stability of conjugated dienes, Diel-Alder, electrophilic addition, free radical addition reactions of conjugated dienes, allylic rearrangement
MODULE-III
Alkyl halides*
SN1 and SN2 reactions - kinetics, order of reactivity of alkyl halides, stereochemistry and rearrangement of carbocations. SN1 versus SN2 reactions, Factors affecting SN1 and SN2 reactions
Structure and uses of ethylchloride, Chloroform, trichloroethylene, tetrachloroethylene, dichloromethane, tetrachloromethane and iodoform.
Alcohols*- Qualitative tests, Structure and uses of Ethyl alcohol, Methyl alcohol, chlorobutanol, Cetosteryl alcohol, Benzyl alcohol, Glycerol, Propylene glycol
MODULE-IV
Carbonyl compounds* (Aldehydes and ketones)
Nucleophilic addition, Electromeric effect, aldol condensation, Crossed Aldol condensation, Cannizzaro reaction, Crossed Cannizzaro reaction, Benzoin condensation, Perkin condensation, qualitative tests, Structure and uses of Formaldehyde, Paraldehyde, Acetone, Chloral hydrate, Hexamine, Benzaldehyde, Vanilin, Cinnamaldehyde.
MODULE-V 
Carboxylic acids*
Acidity of carboxylic acids, effect of substituents on acidity, inductive effect and qualitative tests for carboxylic acids ,amide and ester
Structure and Uses of Acetic acid, Lactic acid, Tartaric acid, Citric acid, Succinic acid. Oxalic acid, Salicylic acid, Benzoic acid, Benzyl benzoate, Dimethyl phthalate, Methyl salicylate and Acetyl salicylic acid
Aliphatic amines* - Basicity, effect of substituent on Basicity. Qualitative test, Structure and uses of Ethanolamine, Ethylenediamine, Amphetamin

Reference :
1. A Text book of Organic chemistry by Arun Bahl and B.S.Bahl
2. A Text book of Organic chemistry by Rakesh kumar Parashar
3.A Text book of Organic chemistry by Dr.O.P. Tandan

SESSION 1

Classification of Organic Compounds

classification of organic compounds-converted

SESSION 2

Common and IUPAC systems of nomenclature of organic compounds

IUPAC

SESSION 3

Common and IUPAC systems of nomenclature of organic compounds

IUPAC

SESSION 4

Common and IUPAC systems of nomenclature of organic compounds

IUPAC

SESSION 5

Common and IUPAC systems of nomenclature of organic compounds

IUPAC

SESSION 6

Common and IUPAC systems of nomenclature of organic compounds

IUPAC

SESSION 7

Alkanes, Alkenes and Conjugated dienes

organic chemistry 2

SESSION 8

SP3 hybridization in alkanes, Halogenation of alkanes, uses of paraffins. Stabilities of alkenes, SP2 hybridization in alkenes

sp3

SESSION 9

SP3 hybridization in alkanes, Halogenation of alkanes, uses of paraffins. Stabilities of alkenes, SP2 hybridization in alkenes

sp3

SESSION 10

E1 and E2 reactions – kinetics, order of reactivity of alkyl halides.

E1 AND E2

SESSION 11

rearrangement of carbocations, Saytzeffs orientation and evidences. E1 verses E2 reactions, Factors affecting E1 and E2 reactions.

E1 AND E2

SESSION 12

rearrangement of carbocations, Saytzeffs orientation and evidences. E1 verses E2 reactions, Factors affecting E1 and E2 reactions.

E1 and E2

SESSION 13

SESSION 14

Markownikoff’s orientation, free radical addition reactions of alkenes, Anti Markownikoff’s orientation.

ORGANIC CHEM

SESSION 15

Markownikoff’s orientation, free radical addition reactions of alkenes, Anti Markownikoff’s orientation.

ORGANIC CHEM

SESSION 16

Stability of conjugated dienes, Diel-Alder, electrophilic addition.

chapter diene

SESSION 17

free radical addition reactions of conjugated dienes, allylic rearrangement

chapter diene

SESSION 18

free radical addition reactions of conjugated dienes, allylic rearrangement

chapter diene

SESSION 19

Introduction to Alkyl halides.

organic chemistry 4

SESSION 20

SN1 and SN2 reactions - kinetics, order of reactivity of alkyl halides.

alkyl halides - Copyorganic chemistry 4

SESSION 21

SN1 and SN2 reactions - kinetics, order of reactivity of alkyl halides.

organic chemistry 4

SESSION 22

stereochemistry and rearrangement of carbocations

rearrangements-converted-converted

SESSION 23

SN1 versus SN2 reactions

Substitution Reactions sn1 sn2 - Copy

SESSION 24

Factors affecting SN1 and SN2 reactions.

Substitution Reactions sn1 sn2 - Copy

SESSION 25

Structure and uses of ethylchloride, Chloroform

chcl3 - Copy

SESSION 26

Trichloroethylene,Tetrachloroethylene

SESSION 27

Dihalogen derivatives

SESSION 28

structure and uses of iodoform

SESSION 29

Concept of Alcohols

Alcohols (1)

SESSION 30

Qualitative tests, Structure and uses of Ethyl alcohol, Methyl alcohol

ethyl alcohol - Copy

SESSION 31

Qualitative tests, Structure and uses of chlorobutanol, Cetosteryl alcohol, Benzyl alcohol.

Alcohols (1)

SESSION 32

Qualitative tests, Structure and uses of Glycerol, Propylene glycol.

propylene glycol

SESSION 33

Carbonyl compounds (Aldehydes and ketones)

UNIT IV ORGANIC CHEMISTRY-converted (1)-converted

SESSION 34

Nucleophilic addition, Electromeric effect.

alcohol12345 - Copy

SESSION 35

aldol condensation, Crossed Aldol condensation.

aldol condensation

SESSION 36

Benzoin condensation, Perkin condensation

Benzoin condensation

SESSION 37

qualitative tests, Structure and uses of Formaldehyde, Paraldehyde, Acetone, Chloral hydrate, Hexamine, Benzaldehyde, Vanilin, Cinnamaldehyde.

acetone

SESSION 38

Acidity of carboxylic acids, effect of substituents on acidity

123

SESSION 39

inductive effect and qualitative tests for carboxylic acids ,amide and ester

carboxylic acid

SESSION 40

inductive effect and qualitative tests for carboxylic acids ,amide and ester

carboxylic acid

SESSION 41

SESSION 42

SESSION 43

Basicity, effect of substituent on Basicity.

Chap10 Amines

SESSION 44

Qualitative test, Structure and uses of Ethanolamine, Ethylenediamine, Amphetamine.

amine - Copy

SESSION 45

Qualitative test, Structure and uses of Ethanolamine, Ethylenediamine, Amphetamine.

amine - Copy

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