PHARMACEUTICAL ORGANIC CHEMISTRY -II-Practical

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Chinmaya Chidananda Behera

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Core Courses

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Course Name : PHARMACEUTICAL ORGANIC CHEMISTRY -II (Practical)

Code(Credit) : BPHL2101(0-4-0)

Course Objectives

This subject deals with general methods of preparation and purification techniques of organic compounds. The Chemistry of fats and oils and assessing of purity of Fats and Oils by  determining the analytical constants

Learning Outcomes

  • Preparation and Purification of Organic compounds
  • Qualitative analysis of Fats and Oils by determining analytical constants

Course Syllabus

I Experiments involving laboratory techniques
• Recrystallization
• Steam distillation
II Determination of following oil values (including standardization of reagents)
• Acid value
• Saponification value
• Iodine value
III Preparation of compounds
• Benzanilide/Phenyl benzoate/Acetanilide from Aniline/ Phenol /Aniline by acylation reaction.
• 2,4,6-Tribromo aniline/Para bromo acetanilide from Aniline/
• Acetanilide by halogenation (Bromination) reaction.
• 5-Nitro salicylic acid/Meta di nitro benzene from Salicylic acid / Nitro benzene by nitration reaction.
• Benzoic acid from Benzyl chloride by oxidation reaction.
• Benzoic acid/ Salicylic acid from alkyl benzoate/ alkyl salicylate by hydrolysis reaction.
• 1-Phenyl azo-2-napthol from Aniline by diazotization and coupling reactions.
• Benzil from Benzoin by oxidation reaction.
• Dibenzal acetone from Benzaldehyde by Claison Schmidt reaction
• Cinnammic acid from Benzaldehyde by Perkin reaction
• P-Iodo benzoic acid from P-amino benzoic acid

Session Plan

Session 1

To perform the crystallization of the supplied Organic compounds, Video tutorial: Re-crystallization of Organic compounds

Session 2

To perform the Distillation of the given Organic compound, Video tutorial: Introduction to Steam distillation  Carrying out steam distillation

Session 3

To perform the Determination of acid value of Supplied Plant oil, Video tutorial: Determination of Acid Value in Biodiesel

Session 4

To perform the Determination of Saponification value of Supplied Plant oil, Video tutorial: https://www.youtube.com/watch?v=ersHDsiAVko

Session 5

To perform the Determination of Iodine value of Supplied Plant oil, Video tutorial: Determination of Iodine value

Session 6

To perform the preparation of Benzanilide from aniline by Benzoylation (Schotten Baumann Reaction), Video tutorial: Preparation of Bezanilide

Session 7

To perform the preparation of Phenylbenzoate from Phenol by Benzoylation (Schotten Baumann Reaction), Video tutorial: Preparation of Phenyl benzoate

Session 8

To perform the preparation of Acetanilide from Aniline by Acetylation (Schotten Baumann Reaction), Video tutorial: Preparation of Acetylation

Session 9

To perform the preparation of 2,4,6-Tribromoaniline by Bromination of Anilinw (Halogenation of Aromatic compound), Video tutorial: Preparation of tribromophenol

Session 10

To perform the preparation of 5-Nitrosalicylic acid by nitration of Salicylic acid (Nitration of Aromatic compound), Video tutorial: Preparation of 5-Nitrosalicylic acid

Session 11

To perform the preparation of Benzoic acid from Toluene by oxidation reaction (Oxidation of carbon), Video tutorial: Preparation of benzoic acid

Session 12

To perform the preparation of 1-Phenyl azo-2-napthol from Aniline by diazotization and coupling reactions (Diazotization reaction), Video tutorial: Preparation of Azo dye

Session 13

To perform the preparation of Benzil from Benzoin by oxidation reaction, Video tutorial: Preparation of Benzil

Session 14

To perform the preparation of Dibenzal acetone from Benzaldehyde by Claisen Schmidt reaction, Video tutorial: Preparation of Dibenza acetal

Session 15

To perform the preparation of Cinnammic acid from Benzaldehyde by Perkin reaction, Video tutorial: Preparation of Cinnammic acid

Session 16

To perform the preparation of P-Iodo benzoic acid from P-amino benzoic acid, Video tutorial: Preparation of P-Iodo benzoic acid

Book References

1. Practical Organic Chemistry by Mann and Saunders.
2. Vogel’s textbook of Practical Organic Chemistry
3. Advanced Practical organic chemistry by N.K.Vishnoi.
4. Introduction to Organic Laboratory techniques by Pavia, Lampman and Kriz.

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