Pharmacology III Practical

Teacher

Ashirbad Nanda

Category

Core Courses

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Course Name: Pharmacology III (Practical)

Code(Credit) : BPHL3202 (0-2-0)

Course Objectives

This subject is intended to impart fundamental knowledge on various aspects (classification, mechanism of action, therapeutic effects, clinical uses, side effects, and contraindications) of drugs acting on the respiratory and gastrointestinal system, infectious diseases, immune-pharmacology and in addition, emphasis on the principles of toxicology and chrono-pharmacology.

Course outcome

CO Statement Mapping with POs
CO-1 Understand the mechanism of drug action and its relevance in the treatment of different infectious diseases

 

 PO1, PO2, PO3, PO10
CO-2 Comprehend the principles of toxicology and treatment of various poisonings

 

PO1, PO2, PO5, PO6
CO-3 Appreciate the correlation of pharmacology with related medical sciences.

 

PO1, PO2, PO5, PO6
CO-4 Able to appraise the principles of pharmacology aspects of various rugs

 

PO1, PO2, PO3, PO6
CO-5 To get knowledge for the practical skills required to conduct preclinical toxicity studies.

 

PO1, PO5, PO6

Course Syllabus

1. Dose calculation in pharmacological experiments
2. Antiallergic activity by mast cell stabilization assay
3. Study of anti-ulcer activity of a drug using pylorus ligand (SHAY) rat model and
NSAIDS induced ulcer model.
4. Study of effect of drugs on gastrointestinal motility
5. Effect of agonist and antagonists on guinea pig ileum
6. Estimation of serum biochemical parameters by using semi- autoanalyser
7. Effect of saline purgative on frog intestine
8. Insulin hypoglycemic effect in rabbit
9. Test for pyrogens ( rabbit method)
10. Determination of acute oral toxicity (LD50) of a drug from a given data
11. Determination of acute skin irritation / corrosion of a test substance
12. Determination of acute eye irritation / corrosion of a test substance
13. Calculation of pharmacokinetic parameters from a given data
14. Biostatistics methods in experimental pharmacology( student’s t test, ANOVA)
15. Biostatistics methods in experimental pharmacology (Chi square test, Wilcoxon
Signed Rank test)

Session Plan

Session 1

1. Dose calculation in pharmacological experiments

https://youtu.be/wXES7DY30CY

Session 2

2. Antiallergic activity by mast cell stabilization assay

https://www.youtube.com/watch?v=TmIf3Kc_mqI

Session 3

3. Study of anti-ulcer activity of a drug using pylorus ligand (SHAY) rat model and NSAIDS induced ulcer model.

https://youtu.be/heQJe9VpSvo

Session 4

4. Study of effect of drugs on gastrointestinal motility

https://youtu.be/qmdg-_sBG48

Session 5

5. Effect of agonist and antagonists on guinea pig ileum

https://youtu.be/LHTjyB_4phE

Session 6

6. Estimation of serum biochemical parameters by using semi- autoanalyser

https://youtu.be/b69HryqioM0

Session 7

 

7. Effect of saline purgative on frog intestine

https://youtu.be/26dNKYfluK4

Session 8

8. Insulin hypoglycemic effect in rabbit

 

https://youtu.be/cBfoIfiTLPA

Session 9

9. Test for pyrogens ( rabbit method)

https://slideplayer.com/slide/8063453/

Session 10

10. Determination of acute oral toxicity (LD50) of a drug from a given data

https://youtu.be/ekWQExR0TgY

Session 11

 

11. Determination of acute skin irritation / corrosion of a test substance

https://youtu.be/cgUmYk0mBwo

Session 12

12. Determination of acute eye irritation / corrosion of a test substance

https://www.slideshare.net/ajaymandal/acute-eye-irritationcorrosion-405

https://youtu.be/31INC_dBROo

Session 13

13. Calculation of pharmacokinetic parameters from a given data

https://youtu.be/9W_kwn7ZHtI

Session 14

14. Biostatistics methods in experimental pharmacology( student’s t test, ANOVA)

https://www.slideshare.net/DrShovanPadhy1/student-t-test

https://www.slideshare.net/snehkhatri/analysis-of-variance-anova

Session 15

15. Biostatistics methods in experimental pharmacology (Chi square test, Wilcoxon Signed Rank test)

https://youtu.be/f53nXHoMXx4

https://youtu.be/UtP4p1OGmWw

Case Studies

Case Studies

 

 

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