Physical Pharmaceutics-I (Theory)

Teacher

Dr. Rasmita Dash

Category

Core Courses

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Course Name : Physical Pharmaceutics-I

Code(Credit) : BP302T(4-0-0)

Course Objectives

The objectives of the course are

  • Understand factors affecting solubility and solute-solvent interactions.
  • Learn states of matter and key drug properties.

Apply surface tension and complexation principles in drug formulation.

Learning Outcomes

Upon the completion of the course student shall be able to

  1. Apply solubility and diffusion principles in drug formulation.
  2. Classify states of matter and show effects of drug physicochemical properties.
  3. Report on surface phenomena and model surfactant use in formulations.
  4. Analyze drug-protein complexation and interpret stability constants
  5. Choose suitable pH buffers and apply buffer calculations in pharmaceuticals..

Course Syllabus

Unit I                                                                                                                                      

Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors influencing solubility of drugs, Dissolution & drug release, diffusion principles in biological systems. Solubility of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law, real solutions, azeotropic mixtures, fractional distillation. Partially miscible liquids, Critical solution temperature and applications. Distribution law, its limitations and applications

 

Unit II                                                                                                                                      

States of Matter and properties of matter:State of matter, changes in the state of matter, latent heats, vapour pressure, sublimation critical point, eutectic mixtures, gases, aerosols – inhalers, relative humidity, liquid complexes, liquid crystals, glassy states, solid-crystalline, amorphous & polymorphism.

 

Physicochemical properties of drug molecules: Refractive index, optical rotation, dielectric constant, dipole moment, dissociation constant, determinations and applications

 

Unit III                                                                                                                                   

 

Surface and interfacial phenomenon: Liquid interface, surface & interfacial tensions surface free energy, measurement of surface & interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB Scale, solubilisation, detergency, adsorption at solid interface.

 

Unit IV                                                                                                                                   

Complexation and protein binding: Introduction, Classification of Complexation, Applications, methods of analysis, protein binding, Complexation and drug action, crystalline structures of complexes and thermodynamic treatment of stability constants.

 

Unit V                                                                                                                                    

pH, buffers and Isotonic solutions: Sorensen’s pH scale, pH determination (electrometric and calorimetric), applications of buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems, buffered isotonic solutions.

Recommended Books

1. Physical Pharmacy by Alfred Martin
2. Experimental Pharmaceutics by Eugene, Parott.
3. Tutorial Pharmacy by Cooper and Gunn.
4. Stocklosam J. Pharmaceutical Calculations, Lea &Febiger, Philadelphia.
5. Liberman H.A, Lachman C., Pharmaceutical Dosage forms, Tablets, Volume-1 to
3, MarcelDekkar Inc.
6. Liberman H.A, Lachman C, Pharmaceutical Dosage forms. Disperse
systems, volume 1, 2, 3. Marcel Dekkar Inc.
7. Physical Pharmaceutics by Ramasamy C and ManavalanR.
8. LaboratoryManual of Physical Pharmaceutics, C.V.S. Subramanyam, J.
Thimma settee
9. Physical Pharmaceutics by C.V.S. Subramanyam
10. Test book of Physical Phramacy, by Gaurav Jain & Roop K. Khar

Session Plan

Session 1

Solubility of drugs: Introduction

1. Solubility

Session 2

Solubility expressions

1. Solubility expression

Session 3

Factors influencing solubility of drugs

3. Factors Affecting Solubility

Session 4

Quantitative approach to the solubility

4. Measurement of Solubility

Session 5

Solubility enhancement techniques

5. drugSolubility_ketansavjani

Session 6

Diffusion principles in biological systems

Diffusion principles in biological systems

Session 7

Clinical relevence of solubility

Clinical relevence of solubility

Session 8

Henry's law solubility of gas in liquid

Henry's law solubility of gas in liquid

Session 9

Solubility of liquids in liquids, (Binary solutions, ideal solutions)

ideal and real solutions

Session 10

Raoult’s law, real solutions

Solubility of Liquids In Liquids

Session 11

Partially miscible liquids

Partially misible liquids

Session 12

Critical solution temperature and applications

Critical solution temperature and applications

Session 13

Distribution law, its limitations and applications

Distribution Law

Session 14

State of matter introduction

States of matter

Session 15

Chemical Interactions in states of matter

Chemical Interactions in states of matter

 

Session 16

Interactions in states of mater

Interactions in states of mater

Session 17

Solid state, Crystalline, amorphous, polymorphism

Solid state, Crystalline, amorphous, polymorphism

Session 18

Liquid State, Boiling, Heat of Vaporization & critical temperature

Liquid State, Boiling, Heat of Vaporization & critical temperature

Session 19

latent heats, vapour pressure

Latent heat, Vapour pressure

Session 20

Eutectic mixtures

Eutectic mixture

Session 21

Gases, Ideal Gas, Sublimation/ Liquefaction, Aerosols–inhalers, relative humidity

Gases

Session 22

Sublimation/ Liquefaction

Sublimation/ Liquefaction

Session 23

Aerosols–inhalers

Aerosols–inhalers

Session 24

Relative humidity

Relative humidity

Session 25

Liquid complexes

Liquid Crystals

Session 26

Glassy states

Glassy states

Session 27

Physicochemical properties of drug molecules

Physicochemical properties of drug

Session 28

Refractive index, optical rotation

REFRACTIVE INDEX & POLARIMETRY

Session 29

Dielectric constant

Dielectric constant

Session 30

Dipole dipole interaction, refractive index

Dielectric constant

Session 31

Determination of of Physicochemical properties of drug molecules

physicochemical properties & determination

Session 32

Applications of Physicochemical properties of drug molecules

Drug discovery, design and development3

Session 33

Surface & interfacial tensions

Introduction

Session 34

Surface free energy

Surface free energy

Session 35

Measurement of Surface and interfacial tension

Measurement of Surface and interfacial tension 

Session 36

Spreading coefficient

 Spreading coefficient

Session 37

Spreading coefficient, adsorption at liquid interfaces

Spreading coefficient, adsorption at liquid interfaces

Session 38

Surface active agents

Surface active agents

Session 39

Solubilisation, detergency

Solubilisation, detergency

Session 40

HLB Scale

HLB Scale

Session 41

Wetting

Wetting

Session 42

Introduction, Classification of Complexation

Introduction and classification to complexation

Session 43

Applications of Complexation

Applications of Complexation

Session 44

Methods of analysis of Complexation

Methods of analysis of Complexation

Session 45

Protein binding

Protein Binding

Session 46

Complexation and drug action

Importance of complexation and drug action

Session 47

Crystalline structures of complexes and thermodynamic treatment of stability constants

stability constant of complexes

Session 48

pH, Sorensen’s pH scale

pH, Buffers and Isotonic solution

Session 49

pH determination (electrometric and calorimetric)

pH, Buffers and Isotonic solution-2

Session 50

Applications of buffers

pH, Buffers and Isotonic solution-7

Session 51

Buffer equation, buffer capacity

Buffer equation, buffer capacity

Session 52

Buffers in pharmaceutical and biological systems

Buffers in pharmaceutical and biological systems

Session 53

Buffered isotonic solutions

Buffered isotonic solutions

Our Main Teachers

Dr. Rasmita Dash

Assistant Professor
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Dr. Rasmita Dash holds a Master of Pharmacy (M.Pharm) and a Doctor of Philosophy (Ph.D.) in Pharmaceutical Sciences. Her academic and research pursuits are centered around innovative approaches in drug delivery and design. With a strong foundation in pharmaceutics, her core areas of expertise include Novel Drug Delivery Systems (NDDS), Nanoparticulate Drug Delivery Systems, and […]