Phytochemistry and Toxicology

Teacher

Dr. Srikanta Sahu

Category

Core Courses

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Course Name: Phytochemistry and Toxicology

Code (Credit): CUTM2380 (3-1-0)

  Objective: To know the techniques of isolation, purification and identification of phyto-molecules. To evaluate the toxicity of a substance. Course outcome
COs Course outcomes Mapping COs with POs (High-3, Medium-2, Low-1)
CO1 Able to gain Knowledge on Toxicology. It helps in assessing the fate of foreign chemicals in the environment and of their effects on different biological organization levels. PO1 (3)
CO2 Research and problem Solving PO2(3), PO7(3)
CO7 Environment and Sustainability PO7(3)
CO8 Ethics and Responsibility PO8(3), PO7(3)
After completion of this course a student will be able To do the extraction of phyto-molecules. To identify the phyto-molecules To purify the phyto-molecules To asses the toxicity level in a substance

Course Syllabus

Module I (8 h) Basics of Phytochemistry, isolation, purification and identification techniques of phyto-molecules. Practice 1: Isolation of curcumin from Turmeric Practice 1: Isolation of caffeine from coffe Module-II Modern methods of extraction, application of latest techniques like Spectroscopy, chromatography and electrophoresis Practice 3: Monitoring the isolation of curcumin from turmeric using TLC Practice 4: Monitoring the isolation of caffeine from coffe using TLC Module III Isolation, Identification and Analysis of Phytoconstituents
  1. Terpenoids: Menthol, Citral, Artemisin
  2. Glycosides: Glycyrhetinic acid & Rutin
Practice 5: Purification crude curcumin using column chromatography Module IV Isolation, Identification and Analysis of Phytoconstituents
  1. Alkaloids: Atropine,Quinine,Reserpine,Caffeine
  2. Resins: Podophyllotoxin, Curcumin
Practice 5: Purification crude caffeine using column chromatography Module V Industrial production, estimation and utilization of the following phytoconstituents: Curcumin,  Atropine, Podophyllotoxin, Caffeine, Taxol, Vincristine and Vinblastine Module- VI Introduction to toxicology,  Background of Toxicology, Subdisciplines of toxicology, Acute, Sub acute and chronic toxicology, Module-VII Toxicity Pathways, Mechanism of toxicology, Adverse Outcome Pathways, Dose response relationship  

Session Plan

Session 1 

Basics of Phyto-chemistry

Session 2

Isolation Techniques

Session 3

Purification Techniques

Session 4

Identification Techniques

Session 5

Modern methods of extraction

Session 6

Application of latest techniques

Session 7

chromatography and electrophoresis

Session 8

Isolation of Terpinoids Session 9 Isolation of Menthol, Citral, Artemisin Session 10: Isolation of Menthol, Citral, Artemisin Isolation of Glycosides: Glycyrhetinic acid & Rutin Session 11 Identification of Terpinoids Session 12 Identification of Glycosides Session 13 Analysis of Phyto-constituents Session 14 Industrial production, estimation and utilization of Curcumin,  Atropine, Podophyllotoxin Session 15 Industrial production, estimation and utilization of Caffeine, Taxol, Vincristine and Vinblastine Session 16 Introduction to toxicology Session 17 Background of Toxicology Session 18 Subdisciplines of toxicology Session 19 Acute, Sub acute and chronic toxicology Session 20 Toxicity Pathways, Mechanism of toxicology Session 21 Adverse Outcome Pathways, Session 22 Dose response relationship

Our Main Teachers

Srikanta Sahu completed his Ph.D.  from IIT Delhi in Bio-organic chemistry under the supervision of Prof. V. Haridas. After his PhD, he moved for postdoctoral work at National University of Singapore (NUS) in the field of Bio-medical science and chemical biology under the guidance of Prof. Young Tae Chang. Later, he joined as a core […]