Spectroscopy for Analysis of Natural and Synthetic Compounds

Teacher

Dr. Rosy Mallik

Category

Skill Courses

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Course Name : Spectroscopy for Analysis of Natural and Synthetic Compounds

Code(Credit) : CUTM3128(0-3-1)

Course Objectives

  • To enable the students to analyze and characterize various small to complex organic molecules either obtained from natural sources or synthesized in laboratory

Learning Outcomes

  • Students will learn the basic concepts of different spectroscopic methods and their significance in structural analysis.
  • They will be able to determine structures of organic molecules by applying these spectroscopic methods.
  • Students will obtain hands-on-training in sample preparation, scanning process and analyzing the spectra.
COs Course outcomes Mapping COs with POs (High-3, Medium-2, Low-1)
CO1 To impart knowledge of basic concepts of spectroscopy PO1 ( 3), PO2 (2), PO4(1)
CO2 Understanding of the problem solving techniques of organic spectrosocpy PO1 ( 2),PO2(3), PO5(2)
CO3 Investigation of different patterns of peaks and their origin and hence deduction of structure of organic species. PO2(2), PO4(2), PO5(3)
CO4 To develop analytical skills on predicting and explaining the various spectroscopic patterns for organic molecules PO2(3), PO4(3), PO5(2)

Course Syllabus

Module I:

Unit 1: UV-vis spectroscopy: Introduction, Principle, Instrumentation

Unit 2: Analysis of spectra

Module II:

Unit 1: IR spectroscopy: Introduction, Principle, Instrumentation

Unit 2: Analysis of spectra

Module III:

Unit 1: NMR spectroscopy: Introduction, Principle, Instrumentation,

Unit 2: Proton/ 1H- NMR, 13C-NMR, Analysis of spectra

Unit 3: 2D NMR (NOESY, COSY, HMBC, HMQC, HSQC), Analysis of spectra

Module IV:

Unit 1: Mass spectrometry: Introduction, Principle, Instrumentation

Unit 2: Analysis of spectra

 

Essential Reading:

  1. D. C. Pavia, G. M. Lampman, G. S. Kriz, Introduction to Spectroscopy, 3rd Edition, THOMSON, 2007.
  2. J. Mohan, Organic Spectroscopy, Narosa Publishing House, 2004

 

Supplementary Reading:

  1. B. H. Williams, I. Flemming, Spectroscopy Methods in Organic Chemistry, McGraw Hill, 2005.
  2. R. M. Silverstein, F. X. Webster, D. J. Kiemle, D. L. Bryce, Spectrometric Identification of Organic Compounds, Eighth Edition, John Wilry & Sons, 2017.

Session Plan

Session 1

UV-vis spectroscopy: Introduction, Principle, Instrumentation

Session 2

(Practice):

Analysis of UV-vis spectra.

Session 3

(Practice):
Sample preparation and recording of UV-vis spectra of simple organic compounds

Session 4

IR spectroscopy: Introduction, Principle, Instrumentation

Session 5

(Practice):
Analysis of IR spectra

Session 6

(Practice):
Sample preparation and recording of IR spectra of simple organic compounds

Session 7

NMR spectroscopy: Introduction, Principle, Instrumentation

Session 8

Proton/1H NMR, Chemical shift, Spin-Spin Coupling, Coupling Constant

Session 9

(Practice):
Analyze the structure and predict possible 1H NMR spectra

Session 10

(Practice):
Analyze 1H NMR spectra and predict the structures of unknown compounds

Session 11

13C NMR, principles

Session 12

(Practice):
Analyze the structure and predict possible 13C NMR spectra

Session 13

(Practice):
Analyze 13C NMR and 1H NMR spectra and predict the structures of unknown compounds

Session 14

Principles of different 2D NMR (NOESY, COSY, HMBC, HMQC, HSQC)

Session 15

Principles of different 2D NMR (NOESY, COSY, HMBC, HMQC, HSQC)

Session 16

(Practice):
Analyze the structure and predict possible 2D interactions (NOESY)

Session 17

(Practice):
Analyze the structure and predict possible 2D interactions (COSY)

Session 18

(Practice):
Analyze the structure and predict possible 2D interactions (HMBC)

Session 19

(Practice):
Analyze the structure and predict possible 2D interactions (HMQC)

Session 20

(Practice):
Analyze the structure and predict possible 2D interactions (HSQC)

Session 21

(Practice):

Principles of Mass spectroscopy

Session 22

(Practice):

Analyse the structure and predict possible peaks in mass spectroscopy

Session 23

(Practice):

Analyse the mass spectrum and predict possible fragmentations

Project:

Extract and purify different phytochemicals from plant raw materials and analyse their structure using spectroscopic methods.

Case Studies

Our Main Teachers

  Assistant Professor Centurion University of Technology and Management Odisha, India   Teaching  Organic Chemistry Synthetic methods  Stereochemistry  Natural products Research areas/interests  Synthetic methodology  Natural product synthesis  Organocatalysis About Me   Ph.D in Synthetic organic chemistry from National Chemical Laboratory, Pune Research area: Carbohydrate chemistry, Transition metal catalysis, Methodology and total synthesis. Post-doctoral research: Central […]