Toxicology

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Dr. Atia Arzoo

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Core Courses

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Course Name : Toxicology

Code(Credit) : CUTM1420(3-1-0)

Course Objectives

  • To give students knowledge and skill that allow an overall assessment of the fate of foreign chemicals in the environment and of their effects on different biological organization levels.
  • To develop a conceptual framework to identify toxins and its remedies.

Learning Outcomes

On the completion of the course, the student should be able to:

  • describe sources and fates of chemicals in the environment
  • present and explain mechanisms for adverse effects of chemicals
  • estimate the risk for adverse effects of a chemical on different biological organization levels based on knowledge about the toxicity, degradability and bioavailability of the chemical
  • retrieve and critically evaluate toxicological information from different sources (internet based databases, hand books, scientific articles)
  • independently identify the toxins present in the environment and evaluate the environmental risk assessment

Course Syllabus

Module-1

Concepts of toxicology: Introduction to toxicology, Background of Toxicology, Toxicology for the Twenty-First Century, Acute, sub acute and chronic toxicity.

Practice-1: Action of antibiotics on micro-organisms

Practice-2: Minimum Inhibitory Concentration (MIC) Testing

Module-2

Toxicity Pathways:  Adverse Outcome Pathways (AOPs), Exposure-Based Chemical Prioritization, ER Bioactivity Model, US EPA Endocrine Disruptor Screening Program (EDSP).

Module-3

Toxicity mechanism: Mechanistic Toxicology and Pathway Mapping at the Basics of 21st Century Toxicology, The Concept of the Human Toxome Project, Concept and Tool Development, Omics Technologies and High-Throughput Data.

Module- 4

Integrated Testing Strategies: Why Integrated Testing Strategies? And Strategies for Integrated Testing Strategies, What is an Integrated Testing Strategy?, How to Compose Integrated Testing Strategies, Quality Assurance of integrated Testing Strategies

Module-5

Toxicity beyond chemicals: Legal Background, Economic Background, Tox-21c for Drug Safety, Green Toxicology as Non-regulatory Tox-21c Approaches

Module-6

Ecotoxicology and Risk assessment: Toxicants in air, Toxicants in water, Toxicants in soil, Heavy metal toxicity and its risk assessment.

Practice-3: Water Quality Testing Methods

Practice-4: Determination of heavy metals in soil

Module-7

Toxicity remediation and Application of toxicants:  Replacement of synthetic fertilizer by Biofertilizer, Solid waste management, Bioremediation, Uses of toxins as Nanomedicines, Bioherbicides, Biopesticides.

Practice-5: Preparation of biofertilizer

Practice-6: Bio-remediation - Cleaning a Mixture of Oil & Water/Phytoremediation of heavy metals from soil or water.

Recommended Books:

  • Walker, C.H., S.P. Hopkin, R. M. Sibley, and D.P. Peakall. 2012. Principles of Ecotoxicology, Fourth Edition. Boca Raton, FL: CRC Press. ISBN -13: 978-1-4398-6266-7 (soft cover)
  • Newman, M.C. 2014. Fundamentals of Toxicology. 4th Edition. Boca Raton, FL: CRC Press. (Selected Chapters)
  • Newman, M.C. & W.H. Clements. 2008. Ecotoxicology: A Comprehensive Treatment. Boca Raton, FL: CRC Press. (Selected Chapters) Pennings,
  • S.C. and M. D. Bertness. 2001. Salt Marsh Communities. In: Marine Community Ecology.
  • M. D. Bertness, S.D. Gaines, and M. Hay (Editors). Sinauer Associates, Sunderland Massachusetts.

 

 

 

Session 4

Session 5 (Practice) 2 hours

Action of antibiotics on micro-organisms

https://www.youtube.com/watch?v=CkFFdR1m8XU

Session 6 (Practice) 2 hours

Minimum Inhibitory Concentration (MIC) Testing

https://www.youtube.com/watch?v=aYxpA0GL8Ss

Session 15

Why Integrated Testing Strategies? And Strategies for Integrated Testing Strategies

https://www.coursera.org/lecture/toxicology-21/why-integrated-testing-strategies-LGGs0

Session 26

Session 27 (Practice) 2 hours

Water Quality Testing Methods

https://www.youtube.com/watch?v=7rjDhyWtKgQ

Session 28 (Practice) 2 hours

Determination of heavy metals in soil

https://www.youtube.com/watch?v=Py-TYqA72P0

Session 29

Replacement of synthetic fertilizer by Biofertilizer

ttps://byjus.com/biology/biofertilizers/

https://www.youtube.com/watch?v=QgZubFEmVys

Session 35 (Practice) 2 hours

Preparation of biofertilizer

https://www.youtube.com/watch?v=zQvkT0vQdZ0

Session 36 (Practice) 2 hours

Bio-remediation - Cleaning a Mixture of Oil & Water

https://www.youtube.com/watch?v=Z3SxwBPSMqk

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Dr. Atia Arzoo

Assistant Professor
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Dr. Atia Arzoo is having academic training and research experience primarily in the field of Environmental sciences enables her to be an effective faculty in the Department of Environmental Science. She has qualified her Ph.D. degree in Environmental Sciences. Her areas of research and consulting interest include environmental pollution control and management specially in the […]