Cancer Biology -CUTM2366 (3-1-1) by Dr Fahima Dilnawaz

Objectives:To impart basic concepts of cancer biology, various stages in carcinogenesis, molecular cell biology of cancer, cancer metastasis, and cancer.
COs Course outcomes Mapping COs with POs (High-3, Medium-2, Low-1)
CO1 Knowledge of cancer cells, basics of cancer cell culture technique, knowledge of media, and their fundamentals, preservations etc PO1 (3)
CO4, CO7 Students will be able to know the cancer cell culture and its use, maintenance of cell stock, preservation PO9 (3)
CO5 Use of practical approach for cancer cell culture and its methodology for experiments, analysis, and interpretation of data, in molecular biology, preparation of project report. PO2 (3)
Module I: Cancer Cell Biology        Introduction to Cancer --Cell cycle—pRb--Tumor suppressor genes--Knudson’s two-hit hypothesis--p53--Myconcoprotein--TGF-b --Cell cycle and cancer-- Different forms of cancer-- Diet and Cancer
  • Introduction to Cancer (https://www.youtube.com/watch?v=jjfYQMW_nek&t=11s)
  • Cell cycle and cancer (https://www.youtube.com/watch?v=dpipegI4lgg, https://www.youtube.com/watch?v=26cJbmDaH90)
  • pRb--Tumor suppressor genes (https://www.youtube.com/watch?v=C-Njz_iSvLI), https://www.youtube.com/watch?v=KtlLx2ewygc)
  • Knudson’s two-hit hypothesis (https://www.youtube.com/watch?v=tuwogQmcAps)
  • p53—Myconcoprotein (https://www.youtube.com/watch?v=_Isvd01XvSs, https://www.youtube.com/watch?v=cSXFjUpACWE)
  • Different forms of cancer (https://www.youtube.com/watch?v=ga6FBT35TRA)
  • Diet and Cancer (https://www.youtube.com/watch?v=dEBi-yvSWmQ)
  Module II: Carcinogenesis   Stages of Carcinogenesis-Environment, Genetics, and Cancer—Causes of cancer—Classes and Types of Carcinogens—Ecogenetics and Cancer risk— Carcinogen Metabolism—Epigenetics-- DNA repair, pathways, and Human Cancer
  • Stages of Carcinogenesis (n.video.search.yahoo.com/search/video;_ylt=Awrx.840759kboYnzGHmHAx.;_ylu=c2VjA3NlYXJjaAR2dGlkAw--?p=•%09Stages+of+Carcer%2C+youtube)
  • Environment, Genetics, and Cancer (https://www.youtube.com/watch?v=wSlIy3lt0CA)
  • Classes and Types of Carcinogens (https://www.youtube.com/watch?v=sXHuwP5HCuk)
  • Ecogenetics and Cancer risk (https://www.youtube.com/watch?v=sTwXYwwarJE, https://www.youtube.com/watch?v=e8xwbo8FSs4)
  • Carcinogen Metabolism (https://www.youtube.com/watch?v=kYmLQP2M-qo)
  • Epigenetics-- DNA repair pathways (https://www.youtube.com/watch?v=JMT6oRYgkTk, https://www.youtube.com/watch?v=3xBeELy6HlE)
  • Human Cancer (https://www.youtube.com/watch?v=GhfrHjBX5eA)
  Module III: Signal Transduction: Cell Division, Differentiation, And Apoptosis           Signal Transduction-Growth factor signaling-EGF signaling-Oncogenes—Wnt signaling-- Immune system in cancer—B cell, T cell, and Cytokine signaling— Neuroendcrine system in cancer-Hormone and Neurotransmitter signaling— Apoptosis—Cancer stem cells
  • Cell Division, Differentiation, And Apoptosis (n.video.search.yahoo.com/search/video?fr=mcafee&ei=UTF-8&p=Cell+Division%2C+differentiation%2C+apoptosis%2C+youtube&vm=r&type=E210IN885G0#id=1&vid=d0ed1bc5c74fa469853f4e3961a9b040&action=click, https://www.youtube.com/watch?v=XKZhcYetvsc)
  • Signal Transduction-Growth factor signaling (https://www.youtube.com/watch?v=qOVkedxDqQo, https://www.youtube.com/watch?v=TfPHZqT7b9A)
  • EGF signaling-Oncogenes (https://www.youtube.com/watch?v=fqo7EYIh0XM)
  • Wnt signaling (https://www.youtube.com/watch?v=-VBO7HZS9i8)
  • Immune system in cancer (https://www.youtube.com/watch?v=jDdL2bMQXfE)
  • B cell, T cell, and Cytokine signaling (https://www.youtube.com/watch?v=7g2f0dhp2w8)
  • Neuroendcrine system in cancer (https://www.youtube.com/watch?v=XGDzQDrhRV0)
  • Hormone and Neurotransmitter signaling (https://www.youtube.com/watch?v=RacgEU7f53g)
  • Apoptosis (https://www.youtube.com/watch?v=-vmtK-bAC5E)
  • Cancer stem cells (https://www.youtube.com/watch?v=mnTQTjBZoAE)
Module IV:Metastasis and Angiogenesis    Tumor microenvironment in cancer progression—Invasion and Metastasis-Stages in metastasis and the factors involved in the invasive process—Angiogenesis- VEGF signalling.
  • Tumor microenvironment in cancer progression (https://www.youtube.com/watch?v=edVMhuDYXlc)
  • Invasion and Metastasis-Stages in metastasis (https://www.youtube.com/watch?v=G0RxrDFU5Y0)
  • factors involved in the invasive process (https://www.youtube.com/watch?v=eRBmpIldh30)
  • Angiogenesis- VEGF signalling (https://www.youtube.com/watch?v=AiuvB9CYP2c)
Module V: Cancer Therapy, Prevention and Diagnosis Current modalities of treatment-Radiation therapy-Surgery-Chemotherapy- Radiation therapy-Surgery-Chemotherapy —Biological therapy-Cancer prevention and early detection- Imaging and cancer
  • Current modalities of treatment (Radiation therapy-Surgery-Chemotherapy)
(https://www.youtube.com/watch?v=hOGF47eUph0)
  • Biological therapy-Cancer prevention and early detection (https://www.youtube.com/watch?v=4xR-4BLhnvA)
  • Imaging and cancer (https://www.youtube.com/watch?v=EeZNhX0IqsY)
Cancer Biology Practice:
  1. Tumor cell isolation using MACS
  2. Tumor cell growth in different media.
  3. Tumor cell growth with different proteins
  4. Tumor cell regression using plant extract.
  5. Morphological analysis of different cancer cell lines.
 
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