Cancer Biology -CUTM2366 (3-1-1) by Dr Fahima Dilnawaz
Objectives:To impart basic concepts of cancer biology, various stages in carcinogenesis, molecular cell biology of cancer, cancer metastasis, and cancer.
COs |
Course outcomes |
Mapping COs with POs (High-3, Medium-2, Low-1) |
CO1 |
Knowledge of cancer cells, basics of cancer cell culture technique, knowledge of media, and their fundamentals, preservations etc |
PO1 (3) |
CO4, CO7 |
Students will be able to know the cancer cell culture and its use, maintenance of cell stock, preservation |
PO9 (3) |
CO5 |
Use of practical approach for cancer cell culture and its methodology for experiments, analysis, and interpretation of data, in molecular biology, preparation of project report. |
PO2 (3) |
Module I: Cancer Cell Biology
Introduction to Cancer --Cell cycle—pRb--Tumor suppressor genes--Knudson’s two-hit hypothesis--p53--Myconcoprotein--TGF-b --Cell cycle and cancer-- Different forms of cancer-- Diet and Cancer
- Introduction to Cancer (https://www.youtube.com/watch?v=jjfYQMW_nek&t=11s)
- Cell cycle and cancer (https://www.youtube.com/watch?v=dpipegI4lgg, https://www.youtube.com/watch?v=26cJbmDaH90)
- pRb--Tumor suppressor genes (https://www.youtube.com/watch?v=C-Njz_iSvLI), https://www.youtube.com/watch?v=KtlLx2ewygc)
- Knudson’s two-hit hypothesis (https://www.youtube.com/watch?v=tuwogQmcAps)
- p53—Myconcoprotein (https://www.youtube.com/watch?v=_Isvd01XvSs, https://www.youtube.com/watch?v=cSXFjUpACWE)
- Different forms of cancer (https://www.youtube.com/watch?v=ga6FBT35TRA)
- Diet and Cancer (https://www.youtube.com/watch?v=dEBi-yvSWmQ)
Module II: Carcinogenesis
Stages of Carcinogenesis-Environment, Genetics, and Cancer—Causes of cancer—Classes and Types of Carcinogens—Ecogenetics and Cancer risk— Carcinogen Metabolism—Epigenetics-- DNA repair, pathways, and Human Cancer
- Stages of Carcinogenesis (n.video.search.yahoo.com/search/video;_ylt=Awrx.840759kboYnzGHmHAx.;_ylu=c2VjA3NlYXJjaAR2dGlkAw--?p=•%09Stages+of+Carcer%2C+youtube)
- Environment, Genetics, and Cancer (https://www.youtube.com/watch?v=wSlIy3lt0CA)
- Classes and Types of Carcinogens (https://www.youtube.com/watch?v=sXHuwP5HCuk)
- Ecogenetics and Cancer risk (https://www.youtube.com/watch?v=sTwXYwwarJE, https://www.youtube.com/watch?v=e8xwbo8FSs4)
- Carcinogen Metabolism (https://www.youtube.com/watch?v=kYmLQP2M-qo)
- Epigenetics-- DNA repair pathways (https://www.youtube.com/watch?v=JMT6oRYgkTk, https://www.youtube.com/watch?v=3xBeELy6HlE)
- Human Cancer (https://www.youtube.com/watch?v=GhfrHjBX5eA)
Module III: Signal Transduction:
Cell Division, Differentiation, And Apoptosis Signal Transduction-Growth factor signaling-EGF signaling-Oncogenes—Wnt signaling-- Immune system in cancer—B cell, T cell, and Cytokine signaling— Neuroendcrine system in cancer-Hormone and Neurotransmitter signaling— Apoptosis—Cancer stem cells
- Cell Division, Differentiation, And Apoptosis (n.video.search.yahoo.com/search/video?fr=mcafee&ei=UTF-8&p=Cell+Division%2C+differentiation%2C+apoptosis%2C+youtube&vm=r&type=E210IN885G0#id=1&vid=d0ed1bc5c74fa469853f4e3961a9b040&action=click, https://www.youtube.com/watch?v=XKZhcYetvsc)
- Signal Transduction-Growth factor signaling (https://www.youtube.com/watch?v=qOVkedxDqQo, https://www.youtube.com/watch?v=TfPHZqT7b9A)
- EGF signaling-Oncogenes (https://www.youtube.com/watch?v=fqo7EYIh0XM)
- Wnt signaling (https://www.youtube.com/watch?v=-VBO7HZS9i8)
- Immune system in cancer (https://www.youtube.com/watch?v=jDdL2bMQXfE)
- B cell, T cell, and Cytokine signaling (https://www.youtube.com/watch?v=7g2f0dhp2w8)
- Neuroendcrine system in cancer (https://www.youtube.com/watch?v=XGDzQDrhRV0)
- Hormone and Neurotransmitter signaling (https://www.youtube.com/watch?v=RacgEU7f53g)
- Apoptosis (https://www.youtube.com/watch?v=-vmtK-bAC5E)
- Cancer stem cells (https://www.youtube.com/watch?v=mnTQTjBZoAE)
Module IV:Metastasis and Angiogenesis
Tumor microenvironment in cancer progression—Invasion and Metastasis-Stages in metastasis and the factors involved in the invasive process—Angiogenesis- VEGF signalling.
- Tumor microenvironment in cancer progression (https://www.youtube.com/watch?v=edVMhuDYXlc)
- Invasion and Metastasis-Stages in metastasis (https://www.youtube.com/watch?v=G0RxrDFU5Y0)
- factors involved in the invasive process (https://www.youtube.com/watch?v=eRBmpIldh30)
- Angiogenesis- VEGF signalling (https://www.youtube.com/watch?v=AiuvB9CYP2c)
Module V: Cancer Therapy, Prevention and Diagnosis
Current modalities of treatment-Radiation therapy-Surgery-Chemotherapy- Radiation therapy-Surgery-Chemotherapy —Biological therapy-Cancer prevention and early detection- Imaging and cancer
- Current modalities of treatment (Radiation therapy-Surgery-Chemotherapy)
(https://www.youtube.com/watch?v=hOGF47eUph0)
- Biological therapy-Cancer prevention and early detection (https://www.youtube.com/watch?v=4xR-4BLhnvA)
- Imaging and cancer (https://www.youtube.com/watch?v=EeZNhX0IqsY)
Cancer Biology Practice:
- Tumor cell isolation using MACS
- Tumor cell growth in different media.
- Tumor cell growth with different proteins
- Tumor cell regression using plant extract.
- Morphological analysis of different cancer cell lines.