Pharmaceutical Engineering Practical

Teacher

Binapani Barik

Category

Core Courses

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Course Name: Pharmaceutical Engineering Practical

Code(Credit):BPHL2104(0-2-0)

Course Objectives

This course is designed to impart a fundamental knowledge on the art and science of various unit operations used in pharmaceutical industry.

Course Outcomes

CO Statements
CO-1 To know various unit operations used in Pharmaceutical industries
CO-2 To understand the material handling techniques
CO-3 To get knowledge to perform various processes involved in pharmaceutical manufacturing process
CO-4 To carry out various test to prevent environmental pollution
CO-5 To appreciate and comprehend significance of plant lay out design for optimum use of resources

COs & POs Mapping

CO Statements PO Mapping
CO-1 To know various unit operations used in Pharmaceutical industries PO1, PO2, PO3, PO6, PO10, PO11
CO-2 To understand the material handling techniques PO1, PO6, PO7, PO11
CO-3 To get knowledge to perform various processes involved in pharmaceutical manufacturing process PO1, PO2, PO3, PO6, PO10, PO11
CO-4 To carry out various test to prevent environmental pollution PO1, PO7, PO10, PO11
CO-5 To appreciate and comprehend significance of plant lay out design for optimum use of resources PO1, PO3, PO7, PO10, PO11

Course Syllabus

1. Determination of radiation constant of brass, iron, unpainted and painted glass.
2.Steam distillation – To calculate the efficiency of steam distillation.
3.To determine the overall heat transfer coefficient by heat exchanger.
4.Construction of drying curves (for calcium carbonate and starch).
5.Determination of moisture content and loss on drying.
6.Determination of humidity of air – i) From wet and dry bulb temperatures –use of Dew point method.
7.Description of Construction working and application of Pharmaceutical Machinery such as rotary tablet machine, fluidized bed coater, fluid energy mill, de humidifier.
8.Size analysis by sieving – To evaluate size distribution of tablet granulations – Construction of various size frequency curves including arithmetic andlogarithmic probability plots.
9.Size reduction: To verify the laws of size reduction using ball mill and determining Kicks, Rittinger’s, Bond’s coefficients, power requirement and critical speed of Ball Mill.
10.Demonstration of colloid mill, planetary mixer, fluidized bed dryer, freeze dryer and such othermajor equipment.
11.Factors affecting Rate of Filtration and Evaporation (Surface area, Concentration and Thickness/ viscosity
12.To study the effect of time on the Rate of Crystallization.
13.To calculate the uniformity Index for given sample by using Double Cone Blender.

Session Plan

EXPERIMENT-1

1.Determination of radiation constant of brass, iron, unpainted and painted glass.

experiment-1

Radiation

EXPERIMENT- 2

2.Steam distillation – To calculate the efficiency of steam distillation.

experiment-2

steam Distillation

EXPERIMENT-3

3.To determine the overall heat transfer coefficient by heat exchanger.

experiment-3

Heat Transfer

EXPERIMENT- 4

4.Construction of drying curves (for calcium carbonate and starch).

experiment-4

drying curve

EXPERIMENT- 5

5.Determination of moisture content and loss on drying.

experiment-5

loss on drying

EXPERIMENT- 6

6.Determination of humidity of air – i) From wet and dry bulb temperatures –use of Dew point method.

experiment-6

Dry bulb Wet Bulb

dry

wet

EXPERIMENT- 7

7.Description of Construction working and application of Pharmaceutical Machinery such as rotary tablet machine, fluidized bed coater, fluid energy mill, de humidifier.

experiment-7

rotary

FBC

FEM

Dehumidifier

EXPERIMENT- 8

8.Size analysis by sieving – To evaluate size distribution of tablet granulations – Construction of various size frequency curves including arithmetic andlogarithmic probability plots.

experiment-8

sieve analysis

EXPERIMENT- 9

9.Size reduction: To verify the laws of size reduction using ball mill and determining Kicks, Rittinger’s, Bond’s coefficients, power requirement and critical speed of Ball Mill.

experiment-9

ball mill

EXPERIMENT- 10

10.Demonstration of colloid mill, planetary mixer, fluidized bed dryer, freeze dryer and such othermajor equipment.

experiment-10

colloid mill

planetory mixer

FBD

freeze dryer

EXPERIMENT- 11

11.Factors affecting Rate of Filtration and Evaporation (Surface area, Concentration and Thickness/ viscosity

experiment-11

filtration

evaporation

EXPERIMENT- 12

12.To study the effect of time on the Rate of Crystallization.

experiment-12

crystallization

EXPERIMENT- 13

13.To calculate the uniformity Index for given sample by using Double Cone Blender.

Experiment-13

blender

Experiment-13

Case Studies

Case Studies

Case Studies

Case Studies

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Binapani Barik

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