Course Name: Pharmaceutical Organic Chemistry-III
Code(Credit): BPHT2201(4-0-0)
Pharmaceutical organic chemistry-III
Teacher
Mr. Satish Kanhar
Category
Core Courses
Course Attendees
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Course Objectives
The course objective is to impart knowledge on stereo-chemical aspects of organic compounds and organic reactions, important named reactions, chemistry of important hetero cyclic compounds. It also emphasizes on medicinal and other uses of organic heterocyclic compounds.
Course outcomes
| CO | Statement | Mapping with POs |
| CO-1 | Understand the importance of drug design and different techniques of drug design. | PO1, PO2, PO5 |
| CO-2 | Understand the chemistry of drugs with respect to their biological activity. | PO1, PO2, PO5 |
| CO-3 | Know the metabolism, adverse effects and therapeutic value of drugs. | PO1, PO2, PO5 |
| CO-4 | To develop entrepreneurship qualities that support growth of pharmaceutical | PO1, PO2, PO5 |
| CO-5 | Implementing the knowledge to determine Structure, nomenclature, metabolism and uses of Various Antibiotics., Chemotherapeutic agents. | PO1, PO2, PO5 |
Syllabus
Module I
Stereo isomerism
Optical isomerism –
Optical activity, enantiomerism, diastereoisomerism, meso compounds
Elements of symmetry, chiral and achiral molecules
DL system of nomenclature of optical isomers, sequence rules, RS system of
nomenclature of optical isomers
Reactions of chiral molecules
Racemic modification and resolution of racemic mixture.
Asymmetric synthesis: partial and absolute
Module-II
Geometrical isomerism
Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)
Methods of determination of configuration of geometrical isomers.
Conformational isomerism in Ethane, n-Butane and Cyclohexane.
Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical
activity.
Stereospecific and stereoselective reactions
Module-III
Heterocyclic compounds:
Nomenclature and classification
Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrrole,
Furan, and Thiophene
Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene
Module-IV
Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrazole,
Imidazole, Oxazole and Thiazole. Pyridine, Quinoline, Isoquinoline, Acridine and
Indole. Basicity of pyridine, Synthesis and medicinal uses of Pyrimidine, Purine,
azepines and their derivatives
Module-V
Reactions of synthetic importance
Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch
reduction, Wolff Kishner reduction.
Oppenauer-oxidation and Dakin reaction.
Beckmanns rearrangement and Schmidt rearrangement.
Claisen-Schmidt condensation
References
1. Organic chemistry by I.L. Finar, Volume-I & II.
2. A text book of organic chemistry – Arun Bahl, B.S. Bahl.
3. Heterocyclic Chemistry by Raj K. Bansal
4. Organic Chemistry byMorrison and Boyd
Session Plan
Session 1
Optical activity, enantiomerism, diastereoisomerism, meso compounds
Session 5
DL system of nomenclature of optical isomers, RS system of
nomenclature of optical isomers
Session 8
Geometrical isomerism
Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)
Session 9
Methods of determination of configuration of geometrical isomers
Session 13
Stereospecific and stereoselective reactions
Session 15
Synthesis, reactions and medicinal uses of Pyrrole
Session 16
Synthesis, reactions and medicinal uses of Furan
Session 17
Synthesis, reactions and medicinal uses of Thiophene
Session 18
Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene
Session 25
Synthesis, chemical properties and uses of Quinoline
Session 26
Synthesis, chemical properties and uses of Isoquinoline
Session 27
Synthesis, chemical properties and uses of Indole
Session 28
Synthesis, chemical properties and uses of Acridine
Session 29
Synthesis, chemical properties and uses of Phenothiazine
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