PHARMACEUTICS (Theory)

Teacher

Shubhashree Das

Category

Core Courses Diploma Courses

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Course Name : Pharmaceutics (Theory)

Code(Credit) : CUTM2019(4-0-0)

Course Objectives

This course will discuss the following aspects of pharmaceutical
dosage forms
1. Basic concepts, types and need
2. Advantages and disadvantages, methods of preparation / formulation
3. Packaging and labelling requirements
4. Basic quality control tests, concepts of quality assurance and good
manufacturing practices

Course Outcomes

CO Statements
CO-1 Know the history of profession of pharmacy
CO-2 Understand the basics of different dosage forms, pharmaceutical incompatibilities and pharmaceutical calculations
CO-3 Basic skill of handling of prescription
CO-4 Preparation of various conventional dosage forms
CO-5 Develop entrepreneurship skills that support the growth of Pharmaceutical Industry

Programme Outcomes

PO Outcomes
PO1 Pharmacy Knowledge- Apply knowledge of basic science and Pharmacy.
PO2 Thinking Abilities-Design and conduct experiments, as well as to carry out problem analysis data interpretation
PO3 Planning Abilities-Design and develop process to meet desired needs within realistic constraints.
PO4 Leadership Skills -Function effectively as a leader and member of multidisciplinary teams.
PO5 Professional Identity-Isolate, identify, synthesize, formulate and solve complex pharmaceutical problems.
PO6 The Pharmacist and society-Analyze, screen and ensure quality of drugs/pharmaceuticals for responsible usage of drugs.
PO7 Environment and Sustainability- Understand the impact of pharmaceutical solutions in a global, economic, environmental, and societal context
PO8 Ethics- Understanding of professional and ethical responsibility
PO9 Communication- Communicate effectively
PO10 Modern tool usage-Use the techniques, skills, and modern pharmaceutical instruments and tools necessary for pharmacy profession.
PO11 Lifelong learning -Engage in life-long learning

COs & POs Mapping

CO Statements POs Mapping
CO-1 Know the history of profession of pharmacy PO1, PO7
CO-2 Understand  the basics of different dosage forms, pharmaceutical incompatibilities and pharmaceutical calculations PO1, PO6, PO11
CO-3 Basic skill of handling of prescription PO1, PO2, PO11
CO-4 Preparation of various conventional dosage forms PO1, PO2, PO3, PO6, PO11
CO-5 Develop entrepreneurship skills that support the growth of Pharmaceutical Industry PO2, PO3, PO4, PO11, PO11

Course Syllabus

1. History of the profession of Pharmacy in India in relation to Pharmacy education, industry, pharmacy practice, and various professional associations.
Pharmacy as a career
Pharmacopoeia: Introduction to IP, BP, USP, NF and Extra Pharmacopoeia. Salient features of Indian Pharmacopoeia

2. Packaging materials: Types, selection criteria, advantages and disadvantages of glass, plastic, metal, rubber as packaging materials.

Pharmaceutical aids: Organoleptic (Colouring, flavouring, and sweetening) agents
Preservatives: Definition, types with examples and uses

4. Unit operations: Definition, objectives/applications, principles, construction and workings of:

Size reduction: hammer mill and ball mill
Size separation: Classification powder according to IP, Cyclone separator, Sieves and standards of sieves

Mixing:  Double cone blender, Turbine mixer, Triple roller mill and Silverson mixer homogenizer

Filtration: Theory of filtration, membrane filter and sintered glass filter

Drying: working of fluidized bed dryer and process of freeze drying
Extraction: Definition, Classification, method and applications.

5. Tablets – coated and uncoated, various modified tablets (sustained release, extended-release, fast dissolving, double layered)

Capsules - hard and soft gelatin capsules

Liquid oral preparations - solution, syrup, elixir, emulsion, suspension, dry powder for reconstitution

Topical preparations - ointments, creams, pastes, gels, liniments and lotions, suppositories and pessaries

Nasal preparations, Ear preparations

Powders and granules - Insufflations, dusting powders, effervescent powders and effervescent granules

Sterile formulations – Injectables, eye drops and eye ointments

Immunological products: Sera, vaccines, toxoids and their manufacturing methods.

6. Basic structure, layout, sections and activities of pharmaceutical manufacturing plants
Quality control and quality assurance: Definition and concepts of quality control & quality assurance, current good manufacturing practice (cGMP), Introduction to concept of calibration and validation.

7. Novel drug delivery systems: Introduction, Classification with examples, advantages and challenges.

Recommended Books

1.Pharmaceutics-I by R. M. Mehta, 2017.

2.Introduction to Pharmaceutics- I by Ashok K. Gupta, 2007.

Session Plan

Session 1

History of the profession of Pharmacy in India in relation to Pharmacy education

HISTORY-OF-PHARMACY

Session 2

History of the profession of Pharmacy in India in relation to industry

HISTORY-OF-PHARMACY

Session 3

History of the profession of Pharmacy in India in relation to pharmacy practice, and various professional associations

HISTORY-OF-PHARMACY

Session 4

Pharmacy as a career

Session 5

Pharmacopoeia: Introduction to IP, BP, USP, NF and Extra Pharmacopoeia

Pharmacopoeia

Session 6

Salient features of Indian Pharmacopoeia

Pharmacopoeia

Session 7

Packaging materials: Types, selection criteria, advantages and disadvantages of glass as packaging material

Packaging Materials

Session 8

Advantages and disadvantages of plastic as packaging material

Packaging Materials

Session 9

Advantages and disadvantages advantages and disadvantages of rubber as packaging material

Packaging Materials

Session 10

Pharmaceutical aids: Organoleptic (Colouring, flavouring, and sweetening) agents

Session 11

Preservatives: Definition, types with examples and uses

Session 12

Unit operations: Definition, objectives/applications, principles, construction and workings of:
Size reduction: hammer mill

Size reduction objective and its factors

Study of hammer mill and ball mill

Session 13

Principles, construction and workings of ball mill

Study of hammer mill and ball mill

Session 14

Size separation: Classification powder according to IP, Cyclone separator

Size separation by sifting and official standard for powders

Construction and working of cyclone separator

Session 15

Session 16

Mixing: Double cone blender, Turbine mixer

Mixing and Double cone blender

Turbine mixture

Session 17

Triple roller mill and Silverson mixer homogenizer

Triple roller mill

Silverson Homogeniser

Session 18

Filtration: Theory of filtration

Introduction to filtration and it's theory

Session 19

Membrane filter and Sintered glass filter

Membrane filter and Sintered filter

Session 20

Drying: working of fluidized bed dryer

Drying

Session 21

Process of freeze drying

Drying

Session 22

Extraction: Definition, Classification, method and applications

Extraction

Session 23

Different methods of method and applications

Maceration

Percolation

Session 25

Session 28

Defects in tablet

Defects in tablets

Session 29

Excipients used in tablet preparation

Tablets excipients

Session 30

Tablet coating

Tablet coating (1)

Session 31

Evaluation of tablet

Evaluation of Tablets

Session 32

Capsules - hard gelatin capsules

Introduction to capsule

Hard gelatin capsule

Session 33

Soft gelatin capsules

Soft gelatin capsule

Session 34

Evaluation of capsule

Session 35

Liquid oral preparations - solution

Session 36

Session 37

Session 38

Emulsion

EMULSIONS

Session 39

Suspension

Suspension

Session 40

Dry powder for reconstitution

Session 41

Topical preparations - ointments

Topical Preparations

Session 42

Session 43

Session 44

Session 45

Session 46

Session 47

Session 48

Session 49

Session 50

Session 51

Powders and granules - Insufflations

POWDER AND GRANULES

Session 52

Dusting powders

POWDER AND GRANULES

Session 53

Effervescent powders and effervescent granules

POWDER AND GRANULES

Session 54

Sterile formulations – Injectables

Session 55

Injectables

Session 56

Eye drops

Session 57

Eye ointments

Session 58

Immunological products: Sera

Session 59

Vaccines

Session 60

Toxoids

Session 61

Basic structure, layout, sections and activities of pharmaceutical manufacturing plants

Session 62

Quality control and quality assurance: Definition and concepts of quality control

Session 63

Definition and concepts of quality assurance

Session 64

Current good manufacturing practice (cGMP)

Session 65

Introduction to concept of calibration and validation

Session 66

Novel drug delivery systems: Introduction

Session 67

Novel drug delivery systems:  Classification with examples

Session 68

Novel drug delivery systems: advantages and challenges

Our Main Teachers

Shubhashree Das

Assistant Professor
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